One-step synthesis of spherical/nonspherical polymeric microparticles using non-equilibrium microfluidic droplets

RSC Advances ◽  
2014 ◽  
Vol 4 (26) ◽  
pp. 13557 ◽  
Author(s):  
Tsubasa Ono ◽  
Masumi Yamada ◽  
Yusuke Suzuki ◽  
Tatsuo Taniguchi ◽  
Minoru Seki
Keyword(s):  
Microfluidic Droplets ◽  
Polymeric Microparticles ◽  
One Step ◽  
Non Equilibrium

One-Step Fabrication of Supramolecular Microcapsules from Microfluidic Droplets

Science ◽  
2012 ◽  
Vol 335 (6069) ◽  
pp. 690-694 ◽  
Author(s):  
J. Zhang ◽  
R. J. Coulston ◽  
S. T. Jones ◽  
J. Geng ◽  
O. A. Scherman ◽  
...  
Keyword(s):  
Microfluidic Droplets ◽  
One Step

scholarly journals Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3045
Author(s):  
Tatiana S. Demina ◽  
Liubov A. Kilyashova ◽  
Tatiana N. Popyrina ◽  
Eugenia A. Svidchenko ◽  
Sankar Bhuniya ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Total Yield ◽  
Solvent Evaporation ◽  
Prolonged Release ◽  
Water Emulsion ◽  
Polymeric Microparticles ◽  
One Step ◽  
Evaporation Technique ◽  
Oil Water ◽  
Emulsifying Ability

Biodegradable polymeric microparticles are widely used in drug delivery systems with prolonged-release profiles and/or cell microcarriers. Their fabrication via the oil/water emulsion solvent evaporation technique has normally required emulsifiers in the aqueous phase. The present work aims to evaluate the effectiveness of various polysaccharides, such as chitosan, hyaluronic acid, cellulose, arabinogalactan, guar and their derivatives, as an alternative to synthetic surfactants for polylactide microparticle stabilization during their fabrication. Targeted modification of the biopolymer’s chemical structure was also tested as a tool to enhance polysaccharides’ emulsifying ability. The transformation of biomacromolecules into a form of nanoparticle via bottom-up or top-down methods and their subsequent application for microparticle fabrication via the Pickering emulsion solvent evaporation technique was useful as a one-step approach towards the preparation of core/shell microparticles. The effect of polysaccharides’ chemical structure and the form of their application on the polylactide microparticles’ total yield, size distribution and morphology was evaluated. The application of polysaccharides has great potential in terms of the development of green chemistry and the biocompatibility of the formed microparticles, which is especially important in biomedicine application.

Utilizing a non-equilibrium phase transition for one-step synthesis of metal nano-crystals

2018 ◽  
Vol 5 (3) ◽  
pp. 9972-9980 ◽  
Author(s):  
Alokmay Datta ◽  
Kaustabh Dan ◽  
Biswarup Satpati ◽  
Madhusudan Roy
Keyword(s):  
Phase Transition ◽  
Equilibrium Phase ◽  
One Step ◽  
Equilibrium Phase Transition ◽  
Non Equilibrium

scholarly journals KINETICS QUASIINVARIANTS OF CHEMICAL REACTIONS IN CLOSED SYSTEMS

2019 ◽  
Vol 62 (6) ◽  
pp. 47-52 ◽  
Author(s):  
Vladislav Kh. Fedotov ◽  
Nikolay I. Kol'tsov
Keyword(s):  
Chemical Reactions ◽  
Multiple Equilibria ◽  
Dual Method ◽  
Boundary Values ◽  
Equilibrium Solutions ◽  
Correct Operation ◽  
Exact Time ◽  
Experiment Method ◽  
One Step ◽  
Non Equilibrium

The limitations of the dual-method and its extended version of the multi-experiment method in determining the exact time kinetic (thermodynamic) invariants and approximate invariants (quasiinvariants) of chemical reactions in closed isothermal systems are discussed. It is shown that for reactions, which allow except for internal equilibria, also boundary equilibria (multiple equilibria, multiequilibrium), for example, autocatalytic ones, there are always some "inconvenient" boundary values of reagent concentrations. These "uncomfortable" values cannot be used as the initial concentrations (conditions) for non-equilibrium multi-experiments (forward, reverse or intermediate), because for these values of non-equilibrium solutions cease to exist and, consequently, the reaction can proceed only in the equilibrium regime. As a result, the "usual " method of multi-experiments, using only the boundary values of the equilibrium concentrations of reagents, is not applicable. In this paper, a generalization of this method is proposed and a technique for conducting multi-experiments is developed, which is applicable for wider classes of reactions, including those with boundary equilibria, as well as autocatalytic reactions. This generalized method of multi-experiments (MME) allows one to bypass the limitations of the conventional multi-experiment method (dual-method) and to determine the exact time thermodynamic (kinetic) invariants of linear and some nonlinear chemical reactions, as well as approximate time invariants of any nonlinear chemical reactions in closed isothermal systems. The conditions of multi-experiments which are necessary for the correct operation of this method are determined. Examples of using the generalized method of multi-experiments for one-step and two-step nonlinear reactions with one and two independent reagents, respectively, are given. The kinetic time invariants and quasinvariants found with this method are compared with the exact solutions for the cases where they exist.

scholarly journals One-Step Fabrication of Enzyme-Immobilized Reusable Polymerized Microcapsules from Microfluidic Droplets

ACS Omega ◽  
2019 ◽  
Vol 4 (9) ◽  
pp. 13790-13794 ◽  
Author(s):  
Rohit Varshney ◽  
Shubhra Sharma ◽  
Bhanu Prakash ◽  
Joydev K. Laha ◽  
Debabrata Patra
Keyword(s):  
Microfluidic Droplets ◽  
One Step

scholarly journals Therapeutic Strategies Based on Polymeric Microparticles

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
C. Vilos ◽  
L. A. Velasquez
Keyword(s):  
Materials Science ◽  
Critical Role ◽  
Scientific Work ◽  
Therapeutic Strategies ◽  
Delivery Systems ◽  
Therapeutic Effects ◽  
Strong Impact ◽  
Clinical Drug Development ◽  
Polymeric Microparticles ◽  
One Step

The development of the field of materials science, the ability to perform multidisciplinary scientific work, and the need for novel administration technologies that maximize therapeutic effects and minimize adverse reactions to readily available drugs have led to the development of delivery systems based on microencapsulation, which has taken one step closer to the target of personalized medicine. Drug delivery systems based on polymeric microparticles are generating a strong impact on preclinical and clinical drug development and have reached a broad development in different fields supporting a critical role in the near future of medical practice. This paper presents the foundations of polymeric microparticles based on their formulation, mechanisms of drug release and some of their innovative therapeutic strategies to board multiple diseases.

An Interactive Minicomputer Program for the Indexing and Simulation of Electron Diffraction Patterns

1976 ◽  
Vol 34 ◽  
pp. 542-543
Author(s):  
R.P. Goehner ◽  
W.T. Hatfield ◽  
Prakash Rao
Keyword(s):  
Electron Diffraction ◽  
Real Time ◽  
Pattern Analysis ◽  
Flow Diagram ◽  
Hard Copy ◽  
Time Analysis ◽  
Real Time Analysis ◽  
Transmission Electron ◽  
One Step ◽  
Diffraction Patterns

Computer programs are now available in various laboratories for the indexing and simulation of transmission electron diffraction patterns. Although these programs address themselves to the solution of various aspects of the indexing and simulation process, the ultimate goal is to perform real time diffraction pattern analysis directly off of the imaging screen of the transmission electron microscope. The program to be described in this paper represents one step prior to real time analysis. It involves the combination of two programs, described in an earlier paper(l), into a single program for use on an interactive basis with a minicomputer. In our case, the minicomputer is an INTERDATA 70 equipped with a Tektronix 4010-1 graphical display terminal and hard copy unit.A simplified flow diagram of the combined program, written in Fortran IV, is shown in Figure 1. It consists of two programs INDEX and TEDP which index and simulate electron diffraction patterns respectively. The user has the option of choosing either the indexing or simulating aspects of the combined program.

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