Precise modular synthesis and a structure–property study of acid-cleavable star-block copolymers for pH-triggered drug delivery

2015 ◽  
Vol 6 (9) ◽  
pp. 1553-1566 ◽  
Author(s):  
Jian Hu ◽  
Jinlin He ◽  
Mingzu Zhang ◽  
Peihong Ni
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Structure Property ◽  
Modular Synthesis ◽  
Star Block Copolymers

A series of well-defined three-armed star-block copolymers (mPEG-a-PCL-a-)3 linked with acid-cleavable acetal groups have been prepared and used for the pH-triggered delivery of doxorubicin.

AB2-type miktoarm poly(l-lactide)-b-poly(N-acryloylmorpholine) amphiphilic star block copolymers as nanocarriers for drug delivery

2018 ◽  
Vol 132 ◽  
pp. 112-119 ◽  
Author(s):  
Kalyan Ramesh ◽  
Baskaran Thangagiri ◽  
Avnish Kumar Mishra ◽  
Byung-Hyun Ahn ◽  
Yeong-Soon Gal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Star Block Copolymers

Self-assembled micelles of well-defined pentaerythritol-centered amphiphilic A4B8 star-block copolymers based on PCL and PEG for hydrophobic drug delivery

Polymer ◽  
2011 ◽  
Vol 52 (13) ◽  
pp. 2799-2809 ◽  
Author(s):  
Mohammad Reza Nabid ◽  
Seyed Jamal Tabatabaei Rezaei ◽  
Roya Sedghi ◽  
Hassan Niknejad ◽  
Ali Akbar Entezami ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Hydrophobic Drug ◽  
Self Assembled ◽  
Star Block Copolymers

scholarly journals Preparation of Doxorubicin-Loaded Amphiphilic Poly(D,L-Lactide-Co-Glycolide)-b-Poly(N-Acryloylmorpholine) AB2 Miktoarm Star Block Copolymers for Anticancer Drug Delivery

Materials ◽  
2020 ◽  
Vol 13 (17) ◽  
pp. 3713
Author(s):  
Kalyan Ramesh ◽  
Avnish Kumar Mishra ◽  
Jin Kon Kim ◽  
Yeon Tae Jeong ◽  
Yeong-Soon Gal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Anticancer Drug ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
Gel Permeation Chromatography ◽  
Critical Micellar Concentration ◽  
Anticancer Drug Delivery ◽  
Miktoarm Star ◽  
Star Block Copolymers

Owing to their unique topology and physical properties, micelles based on miktoarm amphiphilic star block copolymers play an important role in the biomedical field for drug delivery. Herein, we developed a series of AB2-type poly(D,L-lactide-co-glycolide)-b-poly(N-acryloyl morpholine) (PLGA-b-PNAM2) miktoarm star block copolymers by reversible addition–fragmentation chain–transfer polymerization and ring-opening copolymerization. The resulting miktoarm star polymers were investigated by 1H NMR spectroscopy and gel permeation chromatography. The critical micellar concentration value of the micelles increases with an increase in PNAM block length. As revealed by transmission electron microscopy and dynamic light scattering, the amphiphilic miktoarm star block copolymers can self-assemble to form spherical micellar aggregates in water. The anticancer drug doxorubicin (DOX) was encapsulated by polymeric micelles; the drug-loading efficiency and drug-loading content of the DOX-loaded micelles were 81.7% and 9.1%, respectively. Acidic environments triggered the dissociation of the polymeric micelles, which led to the more release of DOX in pH 6.4 than pH 7.4. The amphiphilic PLGA-b-PNAM2 miktoarm star block copolymers may have broad application as nanocarriers for controlled drug delivery.

Thermoresponsive star-like γ-substituted poly(caprolactone)s for micellar drug delivery

2017 ◽  
Vol 5 (28) ◽  
pp. 5632-5640 ◽  
Author(s):  
Katherine E. Washington ◽  
Ruvanthi N. Kularatne ◽  
Jia Du ◽  
Yixin Ren ◽  
Matthew J. Gillings ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Star Block Copolymers ◽  
Poly Caprolactone

Fully biodegradable amphiphilic thermoresponsive star block copolymers featuring 4 and 6 arms are reported for micellar delivery of doxorubicin.

Phase behavior of low-functionality, telechelic star block copolymers

2010 ◽  
Vol 144 ◽  
pp. 143-157 ◽  
Author(s):  
Federica Lo Verso ◽  
Athanassios Z. Panagiotopoulos ◽  
Christos N. Likos
Keyword(s):  
Block Copolymers ◽  
Phase Behavior ◽  
Star Block Copolymers

Modular Synthesis of Amphiphilic Chitosan Derivatives Based on Copper-Free Click Reaction for Drug Delivery

2021 ◽  
pp. 120798
Author(s):  
Yu Tao ◽  
Ding Qu ◽  
Chunli Tian ◽  
Yingshuang Huang ◽  
Lingjing Xue ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Click Reaction ◽  
Chitosan Derivatives ◽  
Modular Synthesis

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

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