How does a tiny terminal alkynyl end group drive fully hydrophilic homopolymers to self-assemble into multicompartment vesicles and flower-like complex particles?

2014 ◽  
Vol 5 (17) ◽  
pp. 5077-5088 ◽  
Author(s):  
Tingting Liu ◽  
Wei Tian ◽  
Yunqing Zhu ◽  
Yang Bai ◽  
Hongxia Yan ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Assembly Behavior ◽  
End Group

We report an unusual self-assembly behavior driven by a tiny terminal alkynyl end group in fully hydrophilic homopolymers which form multicompartment vesicles and flower-like nanoparticles in aqueous solution.

scholarly journals Complex Self-Assembly Behavior of Bis-hydrophilic PEO-b-PCL-b-PMOXA Triblock Copolymers in Aqueous Solution

2017 ◽  
Vol 50 (18) ◽  
pp. 7155-7168 ◽  
Author(s):  
Evgeniia V. Konishcheva ◽  
Ulmas E. Zhumaev ◽  
Maximilian Kratt ◽  
Valentin Oehri ◽  
Wolfgang Meier
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Assembly Behavior

Synthesis and self-assembly behavior of POSS-embedded hyperbranched polymers

2015 ◽  
Vol 51 (39) ◽  
pp. 8296-8299 ◽  
Author(s):  
Dawei Li ◽  
Yuguang Niu ◽  
Yanyu Yang ◽  
Xing Wang ◽  
Fei Yang ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Hyperbranched Polymers ◽  
Simple Approach ◽  
Morphological Transition ◽  
Assembly Behavior

We demonstrate a simple approach to prepare POSS-embedded hyperbranched amphiphiles, presenting morphological transition from micelle to vesicle in aqueous solution.

scholarly journals On the Aqueous Solution Behavior of C-Substituted 3,1,2-Ruthenadicarbadodecaboranes

Inorganics ◽  
2019 ◽  
Vol 7 (7) ◽  
pp. 91 ◽  
Author(s):  
Marta Gozzi ◽  
Benedikt Schwarze ◽  
Peter Coburger ◽  
Evamarie Hey-Hawkins
Keyword(s):  
Aqueous Solution ◽  
Aqueous Solutions ◽  
Self Assembly ◽  
Self Assembling ◽  
Vis Spectroscopy ◽  
Assembly Behavior ◽  
Biological Performance ◽  
Type 3

3,1,2-Ruthenadicarbadodecaborane complexes bearing the [C2B9H11]2− (dicarbollide) ligand are robust scaffolds, with exceptional thermal and chemical stability. Our previous work has shown that these complexes possess promising anti-tumor activities in vitro, and tend to form aggregates (or self-assemblies) in aqueous solutions. Here, we report on the synthesis and characterization of four ruthenium(II) complexes of the type [3-(η6-arene)-1,2-R2-3,1,2-RuC2B9H9], bearing either non-polar (R = Me (2–4)) or polar (R = CO2Me (7)) substituents at the cluster carbon atoms. The behavior in aqueous solution of complexes 2, 7 and the parent unsubstituted [3-(η6-p-cymene)-3,1,2-RuC2B9H11] (8) was investigated via UV-Vis spectroscopy, mass spectrometry and nanoparticle tracking analysis (NTA). All complexes showed spontaneous formation of self-assemblies (108–109 particles mL−1), at low micromolar concentration, with high polydispersity. For perspective applications in medicine, there is thus a strong need for further characterization of the spontaneous self-assembly behavior in aqueous solutions for the class of neutral metallacarboranes, with the ultimate scope of finding the optimal conditions for exploiting this self-assembling behavior for improved biological performance.

Modeling and self-assembly behavior of PEG–PLA–PEG triblock copolymers in aqueous solution

Nanoscale ◽  
2013 ◽  
Vol 5 (19) ◽  
pp. 9010 ◽  
Author(s):  
Xiaohan Wu ◽  
Suming Li ◽  
Fanny Coumes ◽  
Vincent Darcos ◽  
Joséphine Lai Kee Him ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Assembly Behavior

β-Cyclodextrin induced hierarchical self-assembly of a cationic surfactant bearing an adamantane end group in aqueous solution

Soft Matter ◽  
2016 ◽  
Vol 12 (48) ◽  
pp. 9641-9648 ◽  
Author(s):  
Jiao Wang ◽  
Meihuan Yao ◽  
Qintang Li ◽  
Sijing Yi ◽  
Xiao Chen
Keyword(s):  
Aqueous Solution ◽  
Cationic Surfactant ◽  
Self Assembly ◽  
End Group

scholarly journals Effects of Hydrophobic Modifications on the Solution Self-Assembly of P(DMAEMA-co-QDMAEMA)-b-POEGMA Random Diblock Copolymers

Polymers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 338
Author(s):  
Martha Kafetzi ◽  
Stergios Pispas
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Diblock Copolymers ◽  
Raft Polymerization ◽  
Temperature Response ◽  
High Mass ◽  
Alkyl Chains ◽  
Release Studies ◽  
Solution Preparation ◽  
Assembly Behavior

In this work, the synthesis and the aqueous solution self-assembly behavior of novel partially hydrophobically modified poly(2-(dimethylamino) ethyl methacrylate)-b-poly(oligo(ethylelene glycol) methyl ether methacrylatetabel) pH and temperature responsive random diblock copolymers (P(DMAEMA-co-Q6/12DMAEMA)-b-POEGMA), are reported. The chemical modifications were accomplished via quaternization with 1-iodohexane (Q6) and 1-iodododecane (Q12) and confirmed by 1H-NMR spectroscopy. The successful synthesis of PDMAEMA-b-POEGMA precursor block copolymers was conducted by RAFT polymerization. The partial chemical modification of the diblocks resulted in the permanent attachment of long alkyl chains on the amine groups of the PDMAEMA block and the presence of tertiary and quaternary amines randomly distributed within the PDMAEMA block. Light scattering techniques confirmed that the increased hydrophobic character results in the formation of nanoaggregates of high mass and tunable pH and temperature response. The characteristics of the aggregates are also affected by the aqueous solution preparation protocol, the nature of the quaternizing agent and the quaternization degree. The incorporation of long alkyl chains allowed the encapsulation of indomethacin within the amphiphilic diblock copolymer aggregates. Nanostructures of increased size were detected due to the encapsulation of indomethacin into the interior of the hydrophobic domains. Drug release studies demonstrated that almost 50% of the encapsulated drug can be released on demand by aid of ultrasonication.

scholarly journals Homopolymer Self-Assembly via Poly(propylene Sulfone) Networks

2019 ◽  
Author(s):  
Fanfan Du ◽  
Baofu Qiao ◽  
Sharan Bobbala ◽  
sijia yi ◽  
Monica Olvera de la Cruz ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Organic Molecules ◽  
Hierarchical Structures ◽  
Polymer Chains ◽  
Simple System ◽  
Molecular Networks ◽  
Synthetic Materials ◽  
Assembly Behavior ◽  
Poly Propylene

<p>Natural molecules such as peptides and DNA organize dynamically into hierarchical structures with diverse morphologies and sizes. The ability to mimic this self-assembly behavior in synthetic materials has remained an elusive goal. We report on poly(propylene sulfone), a synthetic homopolymer that self-assembles into nanoscale hydrogels of various morphologies including spherical, vesicular, and cylindrical in aqueous solution. Experiments and simulations demonstrate that while the polymer chains are roughly extended and minimally aggregated in DMSO, the addition of water overcomes the steric limitations imposed by the sulfones and induces formation of molecular networks through sulfone-sulfone bonding. Networks collapse and reorganize into distinct morphologies upon hydration, endowing an exceptional capability for capturing organic molecules. This simple system presents a robust platform for controlling nanofabrication.<br></p>

scholarly journals Unique aqueous self-assembly behavior of a thermoresponsive diblock copolymer

2020 ◽  
Vol 11 (2) ◽  
pp. 396-402 ◽  
Author(s):  
Sarah J. Byard ◽  
Cate T. O'Brien ◽  
Matthew J. Derry ◽  
Mark Williams ◽  
Oleksandr O. Mykhaylyk ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Diblock Copolymer ◽  
Self Assembly ◽  
Amphiphilic Diblock Copolymer ◽  
Assembly Behavior

A new amphiphilic diblock copolymer prepared via polymerization-induced self-assembly forms spheres, worms, vesicles or lamellae in aqueous solution on adjusting the temperature.

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