Precisely controlled molecular imprinting of glutathione-s-transferase by orientated template immobilization using specific interaction with an anchored ligand on a gold substrate

2014 ◽  
Vol 5 (16) ◽  
pp. 4764-4771 ◽  
Author(s):  
Yuri Kamon ◽  
Ryo Matsuura ◽  
Yukiya Kitayama ◽  
Tooru Ooya ◽  
Toshifumi Takeuchi
Keyword(s):  
Thin Films ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Specific Interaction ◽  
Specific Interactions ◽  
Synthetic Route ◽  
Gold Substrate ◽  
Imprinted Polymer ◽  
Glutathione S Transferase ◽  
Molecularly Imprinted

We demonstrate a novel synthetic route for molecularly imprinted polymer (MIP) thin films using a bottom-up approach utilizing protein–ligand specific interactions.

Application of Response Surface Methodology to Synthesize Appropriate Molecularly Imprinted Polymer for Diazinon

2014 ◽  
Vol 605 ◽  
pp. 67-70 ◽  
Author(s):  
Mohsen Rahiminezhad ◽  
Seyed Jamaleddin Shahtaheri ◽  
Mohammad Reza Ganjali ◽  
Abbas Rahimi Rahimi Forushani
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Binding Sites ◽  
Capillary Electrochromatography ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Molecular Imprinting Technology ◽  
Cross Linker

Molecular imprinting technology has become an interesting research area to the preparation of specific sorbent material for environmental and occupational sample preparation techniques (1). In the molecular imprinting technology, specific binding sites have been formed in polymeric matrix, which often have an affinity and selectivity similar to antibody-antigen systems (2). In molecular imprinted technology, functional monomers are arranged in a complementary configuration around a template molecule, then, cross-linker and solvent are also added and the mixture is treated to give a porous material containing nono-sized binding sites. After extraction of the template molecule by washing, vacant imprinted sites will be left in polymer, which are available for rebinding of the template or its structural analogue (3). The stability, convention of preparation and low cost of these materials make them particularly attractive (4). These synthetic materials have been used for capillary electrochromatography (5), chromatography columns (6), sensors (7), and catalyze system (8). Depending on the molecular imprinting approach, different experimental variables such as the type and amounts of functional monomers, porogenic solvent, initiator, monomer to cross-linker ratio, temperature, and etc may alter the properties of the final polymeric materials. In this work, chemometric approach based on Central Composite Design (CCD) was used to design the experiments as well as to find the optimum conditions for preparing appropriate diazinon molecularly imprinted polymer.

scholarly journals Molecularly Imprinted Polymer Based Sensors for Medical Applications

Sensors ◽  
2019 ◽  
Vol 19 (6) ◽  
pp. 1279 ◽  
Author(s):  
Yeşeren Saylan ◽  
Semra Akgönüllü ◽  
Handan Yavuz ◽  
Serhat Ünal ◽  
Adil Denizli
Keyword(s):  
Surface Modification ◽  
Homeland Security ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Structural Changes ◽  
Low Cost ◽  
Dimensional Structure ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Physical And Chemical

Sensors have been extensively used owing to multiple advantages, including exceptional sensing performance, user-friendly operation, fast response, high sensitivity and specificity, portability, and real-time analysis. In recent years, efforts in sensor realm have expanded promptly, and it has already presented a broad range of applications in the fields of medical, pharmaceutical and environmental applications, food safety, and homeland security. In particular, molecularly imprinted polymer based sensors have created a fascinating horizon for surface modification techniques by forming specific recognition cavities for template molecules in the polymeric matrix. This method ensures a broad range of versatility to imprint a variety of biomolecules with different size, three dimensional structure, physical and chemical features. In contrast to complex and time-consuming laboratory surface modification methods, molecular imprinting offers a rapid, sensitive, inexpensive, easy-to-use, and highly selective approaches for sensing, and especially for the applications of diagnosis, screening, and theranostics. Due to its physical and chemical robustness, high stability, low-cost, and reusability features, molecularly imprinted polymer based sensors have become very attractive modalities for such applications with a sensitivity of minute structural changes in the structure of biomolecules. This review aims at discussing the principle of molecular imprinting method, the integration of molecularly imprinted polymers with sensing tools, the recent advances and strategies in molecular imprinting methodologies, their applications in medical, and future outlook on this concept.

Stoichiometric molecular imprinting using polymerisable urea and squaramide receptors for the solid phase extraction of organo-arsenic compound roxarsone

2020 ◽  
Vol 12 (47) ◽  
pp. 5729-5736
Author(s):  
Simone Cavalera ◽  
Fabio Di Nardo ◽  
Giulia Spano ◽  
Laura Anfossi ◽  
Panagiotis Manesiotis ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Molecular Imprinting ◽  
Surface Waters ◽  
Molecularly Imprinted Polymer ◽  
Solid Phase ◽  
Phase Extraction ◽  
Functional Monomer ◽  
Arsenic Compound ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

A selective molecularly imprinted polymer prepared with a squaramide-based functional monomer was used for the solid phase extraction of roxarsone from surface waters.

scholarly journals Rapid and selective recognition of Vibrio parahaemolyticus assisted by perfluorinated alkoxysilane modified molecularly imprinted polymer film

RSC Advances ◽  
2020 ◽  
Vol 10 (24) ◽  
pp. 14305-14312 ◽  
Author(s):  
Kaiyue Fu ◽  
Huiwen Zhang ◽  
Yuanyuan Guo ◽  
Juan Li ◽  
Heran Nie ◽  
...  
Keyword(s):  
Polymer Film ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Vibrio Parahaemolyticus ◽  
Selective Recognition ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
High Affinity ◽  
Molecular Imprinting Technology

Molecular imprinting technology offers a means of tailor-made materials with high affinity and selectivity for certain analysts.

Selective determination of semi-volatile thiophene compounds in water by molecularly imprinted polymer thin films with direct headspace gas chromatography sulfur chemiluminescence detection

The Analyst ◽  
2018 ◽  
Vol 143 (5) ◽  
pp. 1117-1123 ◽  
Author(s):  
Hassan Y. Hijazi ◽  
Christina S. Bottaro
Keyword(s):  
Thin Films ◽  
Gas Chromatography ◽  
Molecularly Imprinted Polymer ◽  
Headspace Gas Chromatography ◽  
Chemiluminescence Detection ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Selective Determination ◽  
Headspace Gas

Water-compatible molecularly imprinted polymer films are coupled with headspace gas chromatography sulfur chemiluminescence detection (HS-GC-SCD) for the determination of thiophenes in water.

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