scholarly journals Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging

2014 ◽  
Vol 12 (37) ◽  
pp. 7261-7269 ◽  
Author(s):  
Felix F. Schumacher ◽  
João P. M. Nunes ◽  
Antoine Maruani ◽  
Vijay Chudasama ◽  
Mark E. B. Smith ◽  
...  
Keyword(s):  
Disulfide Bond ◽  
Disulfide Bonds ◽  
Next Generation ◽  
Antibody Drug Conjugates ◽  
Controlled Assembly ◽  
Drug Conjugates ◽  
Antibody Drug

Highly homogeneous ADCs are generated by the efficient bridging of interchain disulfide bonds in trastuzumab, using next generation maleimides.

scholarly journals Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody–Drug Conjugates

2019 ◽  
Vol 47 (10) ◽  
pp. 1156-1163 ◽  
Author(s):  
Donglu Zhang ◽  
Aimee Fourie-O’Donohue ◽  
Peter S. Dragovich ◽  
Thomas H. Pillow ◽  
Jack D. Sadowsky ◽  
...  
Keyword(s):  
Small Molecules ◽  
Disulfide Bonds ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Catalytic Cleavage ◽  
Antibody Drug

Abstract 756: Development of next-generation antibody-drug conjugates for resistant HER2-positive tumors

2018 ◽  
Author(s):  
Vincent Lacasse ◽  
Jeffrey V. Leyton ◽  
Simon Beaudoin ◽  
Mark Barok ◽  
Heikki Joensuu
Keyword(s):  
Next Generation ◽  
Her2 Positive ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

Emerging formats for next-generation antibody drug conjugates

2015 ◽  
Vol 10 (5) ◽  
pp. 463-481 ◽  
Author(s):  
Mahendra P Deonarain ◽  
Gokhan Yahioglu ◽  
Ioanna Stamati ◽  
Jared Marklew
Keyword(s):  
Next Generation ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

The Next Generation of Antibody Drug Conjugates

2014 ◽  
Vol 41 (5) ◽  
pp. 637-652 ◽  
Author(s):  
Fiona Mack ◽  
Michael Ritchie ◽  
Puja Sapra
Keyword(s):  
Next Generation ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

scholarly journals Influence of disulfide bond isoforms on drug conjugation sites in cysteine-linked IgG2 antibody-drug conjugates

mAbs ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 583-595 ◽  
Author(s):  
Lily Liu-Shin ◽  
Adam Fung ◽  
Arun Malhotra ◽  
Gayathri Ratnaswamy
Keyword(s):  
Disulfide Bond ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Drug Conjugation ◽  
Igg2 Antibody ◽  
Antibody Drug
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