Asymmetric synthesis of tetrahydroquinolines through supramolecular organocatalysis

2014 ◽  
Vol 12 (25) ◽  
pp. 4300-4304 ◽  
Author(s):  
Dhevalapally B. Ramachary ◽  
Kodambahalli S. Shruthi
Keyword(s):  
Asymmetric Synthesis ◽  
Reductive Amination

Functionalized chiral tetrahydroquinolines were synthesized through supramolecular organocatalysis using quinidine-NH-thiourea 3c/l-phenylalanine 4i followed by reductive amination from the simple substrates.

Asymmetric Synthesis of a Key Intermediate for Tofacitinib via a Dynamic Kinetic Resolution-Reductive Amination Protocol

2018 ◽  
Vol 22 (12) ◽  
pp. 1817-1822 ◽  
Author(s):  
Gerard K. M. Verzijl ◽  
Christian Schuster ◽  
Thomas Dax ◽  
André H. M. de Vries ◽  
Laurent Lefort
Keyword(s):  
Asymmetric Synthesis ◽  
Reductive Amination ◽  
Kinetic Resolution ◽  
Dynamic Kinetic Resolution

Asymmetric Synthesis of a TRPV1 Antagonist via tert-Butanesulfinamide-Directed Reductive Amination with a Chromanone

2014 ◽  
Vol 18 (2) ◽  
pp. 303-309 ◽  
Author(s):  
Mary E. Bellizzi ◽  
Ashok V. Bhatia ◽  
Steven C. Cullen ◽  
Jorge Gandarilla ◽  
Albert W. Kruger ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Reductive Amination ◽  
Trpv1 Antagonist
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