Asymmetric Synthesis of a TRPV1 Antagonist via tert-Butanesulfinamide-Directed Reductive Amination with a Chromanone

Mary E. Bellizzi; Ashok V. Bhatia; Steven C. Cullen; Jorge Gandarilla; Albert W. Kruger; Dennie S. Welch

doi:10.1021/op400184f

Asymmetric Synthesis of a TRPV1 Antagonist via tert-Butanesulfinamide-Directed Reductive Amination with a Chromanone

Organic Process Research & Development ◽

10.1021/op400184f ◽

2014 ◽

Vol 18 (2) ◽

pp. 303-309 ◽

Cited By ~ 5

Author(s):

Mary E. Bellizzi ◽

Ashok V. Bhatia ◽

Steven C. Cullen ◽

Jorge Gandarilla ◽

Albert W. Kruger ◽

...

Keyword(s):

Asymmetric Synthesis ◽

Reductive Amination ◽

Trpv1 Antagonist

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Asymmetric Synthesis of a Key Intermediate for Tofacitinib via a Dynamic Kinetic Resolution-Reductive Amination Protocol

Organic Process Research & Development ◽

10.1021/acs.oprd.8b00332 ◽

2018 ◽

Vol 22 (12) ◽

pp. 1817-1822 ◽

Cited By ~ 8

Author(s):

Gerard K. M. Verzijl ◽

Christian Schuster ◽

Thomas Dax ◽

André H. M. de Vries ◽

Laurent Lefort

Keyword(s):

Asymmetric Synthesis ◽

Reductive Amination ◽

Kinetic Resolution ◽

Dynamic Kinetic Resolution

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Biomimetic, Reducing Agent-Free Reductive Amination of Fluorocarbonyl Compounds: Practical Asymmetric Synthesis of Enantiopure Fluoroamines and Amino Acids

ACS Symposium Series - Asymmetric Fluoroorganic Chemistry ◽

10.1021/bk-2000-0746.ch006 ◽

1999 ◽

pp. 74-83 ◽

Cited By ~ 2

Author(s):

Vadim A. Soloshonok

Keyword(s):

Amino Acids ◽

Asymmetric Synthesis ◽

Reductive Amination ◽

Reducing Agent

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Highly Enantioselective Hydrogen-Transfer Reductive Amination: Catalytic Asymmetric Synthesis of Primary Amines

Angewandte Chemie International Edition ◽

10.1002/anie.200352503 ◽

2003 ◽

Vol 42 (44) ◽

pp. 5472-5474 ◽

Cited By ~ 198

Author(s):

Renat Kadyrov ◽

Thomas H. Riermeier

Keyword(s):

Asymmetric Synthesis ◽

Hydrogen Transfer ◽

Reductive Amination ◽

Primary Amines ◽

Catalytic Asymmetric Synthesis ◽

Catalytic Asymmetric

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Asymmetric synthesis of tetrahydroquinolines through supramolecular organocatalysis

Organic & Biomolecular Chemistry ◽

10.1039/c4ob00570h ◽

2014 ◽

Vol 12 (25) ◽

pp. 4300-4304 ◽

Cited By ~ 17

Author(s):

Dhevalapally B. Ramachary ◽

Kodambahalli S. Shruthi

Keyword(s):

Asymmetric Synthesis ◽

Reductive Amination

Functionalized chiral tetrahydroquinolines were synthesized through supramolecular organocatalysis using quinidine-NH-thiourea 3c/l-phenylalanine 4i followed by reductive amination from the simple substrates.

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ChemInform Abstract: Organocatalytic Asymmetric Synthesis of trans-1,3-Disubstituted Tetrahydroisoquinolines via a Reductive Amination/Aza-Michael Sequence.

ChemInform ◽

10.1002/chin.201102167 ◽

2010 ◽

Vol 42 (2) ◽

pp. no-no

Author(s):

Dieter Enders ◽

Jens X. Liebich ◽

Gerhard Raabe

Keyword(s):

Asymmetric Synthesis ◽

Reductive Amination

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Highly Enantioselective Hydrogen-Transfer Reductive Amination: Catalytic Asymmetric Synthesis of Primary Amines.

ChemInform ◽

10.1002/chin.200411032 ◽

2004 ◽

Vol 35 (11) ◽

Author(s):

Renat Kadyrov ◽

Thomas H. Riermeier

Keyword(s):

Asymmetric Synthesis ◽

Hydrogen Transfer ◽

Reductive Amination ◽

Primary Amines ◽

Catalytic Asymmetric Synthesis ◽

Catalytic Asymmetric

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ChemInform Abstract: Asymmetric Reductive Amination of Cycloalkanones. Part 7. Asymmetric Synthesis of cis-(1R,2R)- and cis-(1S,2S)-2-Arylcyclohexanamines.

ChemInform ◽

10.1002/chin.198937156 ◽

1989 ◽

Vol 20 (37) ◽

Author(s):

C. M. NACHTSHEIM ◽

A. W. FRAHM

Keyword(s):

Asymmetric Synthesis ◽

Reductive Amination

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ChemInform Abstract: Asymmetric Synthesis of Amines by the Reductive Amination of Ketones Using (+)- and (-)-Norephedrine Followed by Periodate Oxidation.

ChemInform ◽

10.1002/chin.199402048 ◽

2010 ◽

Vol 25 (2) ◽

pp. no-no

Author(s):

R. SREEKUMAR ◽

C. N. PILLAI

Keyword(s):

Asymmetric Synthesis ◽

Reductive Amination ◽

Periodate Oxidation

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Organocatalytic Asymmetric Synthesis of trans-1,3-Disubstituted Tetrahydroisoquinolines via a Reductive Amination/Aza-Michael Sequence

Chemistry - A European Journal ◽

10.1002/chem.201001623 ◽

2010 ◽

Vol 16 (32) ◽

pp. 9763-9766 ◽

Cited By ~ 73

Author(s):

Dieter Enders ◽

Jens X. Liebich ◽

Gerhard Raabe

Keyword(s):

Asymmetric Synthesis ◽

Reductive Amination

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Coupled Immobilized Amine Dehydrogenase and Glucose Dehydrogenase for Asymmetric Synthesis of Amines by Reductive Amination with Cofactor Recycling

ChemCatChem ◽

10.1002/cctc.201601446 ◽

2017 ◽

Vol 9 (3) ◽

pp. 425-431 ◽

Cited By ~ 27

Author(s):

Ji Liu ◽

Bryan Q. W. Pang ◽

Joseph P. Adams ◽

Radka Snajdrova ◽

Zhi Li

Keyword(s):

Asymmetric Synthesis ◽

Reductive Amination ◽

Glucose Dehydrogenase ◽

Cofactor Recycling ◽

Amine Dehydrogenase

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