Palladium catalyzed N–H bond insertion and intramolecular cyclization cascade: the divergent synthesis of heterocyclics

2014 ◽  
Vol 12 (16) ◽  
pp. 2533-2537 ◽  
Author(s):  
Dong Ding ◽  
Gang Liu ◽  
Guangyang Xu ◽  
Jian Li ◽  
Guoping Wang ◽  
...  
Keyword(s):  
Intramolecular Cyclization ◽  
One Pot ◽  
Heck Cyclization ◽  
Palladium Catalyzed

A palladium-catalyzed one-pot procedure of N–H insertion and Heck cyclization/base promoted cyclization has been developed.

Palladium-Catalyzed Stereoselective Aza-Wacker–Heck Cyclization: One-Pot Stepwise Strategy toward Tetracyclic Fused Heterocycles

2020 ◽  
Vol 22 (23) ◽  
pp. 9337-9341
Author(s):  
Rong-Shiow Tang ◽  
Li-Yuan Chen ◽  
Chin-Hung Lai ◽  
Ta-Hsien Chuang
Keyword(s):  
One Pot ◽  
Heck Cyclization ◽  
Fused Heterocycles ◽  
Palladium Catalyzed

Assembly of substituted phenanthridines via a cascade palladium-catalyzed coupling reaction, deprotection and intramolecular cyclization

RSC Advances ◽  
2016 ◽  
Vol 6 (23) ◽  
pp. 19571-19575 ◽  
Author(s):  
Jun Ge ◽  
Xiaojian Wang ◽  
Tianqi Liu ◽  
Zeyu Shi ◽  
Qiong Xiao ◽  
...  
Keyword(s):  
Functional Groups ◽  
Intramolecular Cyclization ◽  
Coupling Reaction ◽  
Practical Method ◽  
One Pot ◽  
One Pot Synthesis ◽  
Palladium Catalyzed

A practical method for one-pot synthesis of substituted phenanthridines is described. Via this method, a series of substituted phenanthridines are obtained in good yields with remarkable functional groups compatibility.

Efficient Access to Original 6-Substituted 5-Nitro-2,3-dihydro­imidazo[2,1-b]oxazoles

Synthesis ◽  
2017 ◽  
Vol 49 (12) ◽  
pp. 2775-2785 ◽  
Author(s):  
Fanny Mathias ◽  
Youssef Kabri ◽  
Maxime Crozet ◽  
Patrice Vanelle
Keyword(s):  
Intramolecular Cyclization ◽  
Bromine Atom ◽  
Cross Coupling ◽  
Sonogashira Reaction ◽  
Coupling Reactions ◽  
One Pot ◽  
Cross Coupling Reactions ◽  
Efficient Access ◽  
Palladium Catalyzed ◽  
Hydroxyethyl Group

A one-pot sequential intramolecular cyclization and Suzuki–Miyaura or Sonogashira reaction under microwave irradiation are reported in the 5-nitro-2,3-dihydroimidazo[2,1-b]oxazole series. The intramolecular cyclization of 1-(2,4-dibromo-5-nitro-1H-imidazol-1-yl)propan-2-ol between the hydroxyethyl group and the bromine atom at the 2-position is carried out first, followed by optimization and generalization of the Suzuki–Miyaura and Sonogashira cross-coupling reactions of the bromine atom at the 4-position. The various boronic acids and alkynyl derivatives used to perform these palladium-catalyzed cross-coupling reactions allowed to substitute the 6-position of 5-nitro-2,3-dihydroimidazo[2,1-b]oxazole compounds.

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