Assembly of substituted phenanthridines via a cascade palladium-catalyzed coupling reaction, deprotection and intramolecular cyclization

RSC Advances ◽  
2016 ◽  
Vol 6 (23) ◽  
pp. 19571-19575 ◽  
Author(s):  
Jun Ge ◽  
Xiaojian Wang ◽  
Tianqi Liu ◽  
Zeyu Shi ◽  
Qiong Xiao ◽  
...  
Keyword(s):  
Functional Groups ◽  
Intramolecular Cyclization ◽  
Coupling Reaction ◽  
Practical Method ◽  
One Pot ◽  
One Pot Synthesis ◽  
Palladium Catalyzed

A practical method for one-pot synthesis of substituted phenanthridines is described. Via this method, a series of substituted phenanthridines are obtained in good yields with remarkable functional groups compatibility.

scholarly journals One-pot synthesis of new $N$-(1-methylpyridin-4(1$H)$-ylidene)amine ligands for palladium-catalyzed Heck coupling reaction

2018 ◽  
Vol 42 ◽  
pp. 63-74 ◽  
Author(s):  
Muhammad ZAFAR ◽  
Sabeen ZAHRA ◽  
Muhammad TAHIR ◽  
Ehsan MUGHAL ◽  
Muhammad NAZAR ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Heck Coupling ◽  
One Pot ◽  
One Pot Synthesis ◽  
Palladium Catalyzed ◽  
Amine Ligands

ChemInform Abstract: Palladium-Catalyzed Cross-Coupling Reaction of N-Alkoxyimidoyl Bromides and Its Application to One-Pot Synthesis of N-Arylamines.

ChemInform ◽  
2012 ◽  
Vol 43 (9) ◽  
pp. no-no
Author(s):  
Masafumi Ueda ◽  
Shoichi Sugita ◽  
Naoki Aoi ◽  
Aoi Sato ◽  
Yuki Ikeda ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
One Pot ◽  
One Pot Synthesis ◽  
Cross Coupling Reaction ◽  
Palladium Catalyzed

scholarly journals One-Pot Synthesis of B-Aryl Carboranes with Sensitive Functional Groups Using Sequential Cobalt- and Palladium-Catalyzed Reactions

Catalysts ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 1348
Author(s):  
Sergey A. Anufriev ◽  
Akim V. Shmal’ko ◽  
Kyrill Yu. Suponitsky ◽  
Igor B. Sivaev
Keyword(s):  
Functional Groups ◽  
X Ray Diffraction ◽  
One Pot ◽  
One Pot Synthesis ◽  
Palladium Catalyzed ◽  
Catalyzed Reactions ◽  
The One ◽  
Solid State Structures ◽  
Derivatives Of

The simple and efficient method was developed for the one-pot synthesis of B-substituted aryl derivatives of ortho-carborane with functional groups sensitive to organolithium and organomagnesium reagents using 9-iodo-ortho-carborane and generated in situ organozinc compounds. The method proposed was used to prepare a series of 9-aryl-ortho-carboranes, including those containing nitrile and ester groups, 9-RC6H4-1,2-C2B10H11 (R = p-Me, p-NMe2, p-OCH2OMe, o-OMe, p-OMe, o-CN, p-CN, o-COOEt, m-COOEt, and p-COOEt). It was demonstrated that the same approach can be used for synthesis of diaryl derivatives of ortho-carborane 9,12-(RC6H4)2-1,2-C2B10H10 (R = H, p-Me). The solid-state structures of 9-RC6H4-1,2-C2B10H11 (R = p-NMe2, p-OCH2OMe, o-OMe, o-CN, p-CN, m-COOEt, and p-COOEt) and 9,12-(p-MeC6H4)2-1,2-C2B10H10 were determined by single crystal X-ray diffraction.

One-pot synthesis of benzoxaborole derivatives from the palladium-catalyzed cross-coupling reaction of alkoxydiboron with unprotected o-bromobenzylalcohols

2015 ◽  
Vol 13 (46) ◽  
pp. 11362-11368 ◽  
Author(s):  
Jianan Zhu ◽  
Ying Wei ◽  
Dongqing Lin ◽  
Changjin Ou ◽  
Linghai Xie ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
One Pot ◽  
Mild Conditions ◽  
One Pot Synthesis ◽  
Cross Coupling Reaction ◽  
Palladium Catalyzed

Under very mild conditions, functionalized benzoxaborole derivatives were prepared in good to excellent yields via a palladium-catalyzed Miyaura borylation reaction of readily available unprotected o-bromobenzylalcohols, and bis(pinacolato)diboron (B2pin2) without the assistance of an acid.

scholarly journals Palladium-Catalyzed Cross Coupling Reaction of N-Alkoxyimidoyl Bromides and Its Application to One-Pot Synthesis of N-Arylamines

2011 ◽  
Vol 59 (9) ◽  
pp. 1206-1208 ◽  
Author(s):  
Masafumi Ueda ◽  
Shoichi Sugita ◽  
Naoki Aoi ◽  
Aoi Sato ◽  
Yuki Ikeda ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
One Pot ◽  
One Pot Synthesis ◽  
Cross Coupling Reaction ◽  
Palladium Catalyzed

Facile Approach to Geminal Heterodihalogenation. One-Pot Synthesis of α-Bromo-α-Chloro Ketones

Synlett ◽  
2020 ◽  
Vol 31 (14) ◽  
pp. 1430-1434
Author(s):  
Ming Bian ◽  
Jin-feng Zhou ◽  
Dong-min Tang
Keyword(s):  
Drug Discovery ◽  
Dimethyl Sulfoxide ◽  
Functional Groups ◽  
Methyl Ketones ◽  
One Pot ◽  
One Pot Synthesis ◽  
Operational Simplicity

An efficient and practical protocol for the geminal heterodihalogenation of methyl ketones by using readily available dimethyl sulfoxide and a combination of HCl and HBr is reported. Control experiments suggested that the acidity of the solution, as well as the oxidizing ability and nucleophilicity of the dimethyl sulfoxide might work cooperatively in ensuring the success of the tandem substitution. Its operational simplicity, easy accessibility, and mild oxidative conditions suggest that the present strategy might be useful for the assembly of bromochloromethyl functional groups in drug discovery.

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