Long-circulating PEGylated manganese ferrite nanoparticles for MRI-based molecular imaging

Nanoscale ◽  
2015 ◽  
Vol 7 (5) ◽  
pp. 2050-2059 ◽  
Author(s):  
Manuel Pernia Leal ◽  
Sara Rivera-Fernández ◽  
Jaime M. Franco ◽  
David Pozo ◽  
Jesús M. de la Fuente ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Ferrite Nanoparticles ◽  
Manganese Ferrite ◽  
Mri Contrast

DualT1andT2MRI contrast agents based on PEGylated manganese ferrite nanoparticles with long circulation times.

Zinc ferrite nanoparticles as MRI contrast agents

2008 ◽  
pp. 2224 ◽  
Author(s):  
Carlos Bárcena ◽  
Amandeep K. Sra ◽  
Girija S. Chaubey ◽  
Chalermchai Khemtong ◽  
J. Ping Liu ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Zinc Ferrite ◽  
Mri Contrast Agents ◽  
Ferrite Nanoparticles ◽  
Mri Contrast

scholarly journals Molecular imaging of atherosclerosis with nanoparticle-based fluorinated MRI contrast agents

Nanomedicine ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. 1817-1832 ◽  
Author(s):  
Rohun U Palekar ◽  
Andrew P Jallouk ◽  
Gregory M Lanza ◽  
Hua Pan ◽  
Samuel A Wickline
Keyword(s):  
Molecular Imaging ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast

scholarly journals Molecular imaging of EGFR/HER2 cancer biomarkers by protein MRI contrast agents

2013 ◽  
Vol 19 (2) ◽  
pp. 259-270 ◽  
Author(s):  
Jingjuan Qiao ◽  
Shenghui Xue ◽  
Fan Pu ◽  
Natalie White ◽  
Jie Jiang ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Contrast Agents ◽  
Cancer Biomarkers ◽  
Mri Contrast Agents ◽  
Mri Contrast

scholarly journals Biological effects of MRI contrast agents: gadolinium retention, potential mechanisms and a role for phosphorus

2017 ◽  
Vol 375 (2107) ◽  
pp. 20170180 ◽  
Author(s):  
Joel Garcia ◽  
Stephen Z. Liu ◽  
Angelique Y. Louie
Keyword(s):  
Molecular Imaging ◽  
Contrast Agents ◽  
Biological Effects ◽  
Blood Pool ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Treatment Regimens ◽  
Gadolinium Retention ◽  
Magnetic Resonance Imaging Mri ◽  
Blood Pool Agents

No discussion of challenges for chemistry in molecular imaging would be complete without addressing the elephant in the room—which is that the purest of chemical compounds needs to interact with a biological system in a manner that does not perturb normal biology while still providing efficacious feedback to assist in diagnosis of disease. In the past decade, magnetic resonance imaging (MRI) agents long considered inert have produced adverse effects in certain patient populations under certain treatment regimens. More recently, inert blood pool agents have been found to deposit in the brain. Release of free metal is often suspected as the culprit but that hypothesis has yet to be validated. In addition, even innocuous agents can cause painful side effects during injection in some patients. In this brief review, we summarize known biological effects for gadolinium- and iron-based MRI contrast agents, and discuss some of the potential mechanisms for the observed biological effects, including the potential role of phosphorus imbalance, related to kidney disease or cancer, in destabilizing gadolinium-based chelates and precipitating free gadolinium. This article is part of the themed issue ‘Challenges for chemistry in molecular imaging’.

scholarly journals Tailored biological retention and efficient clearance of pegylated ultra-small MnO nanoparticles as positive MRI contrast agents for molecular imaging

2014 ◽  
Vol 2 (13) ◽  
pp. 1779-1790 ◽  
Author(s):  
P. Chevallier ◽  
A. Walter ◽  
A. Garofalo ◽  
I. Veksler ◽  
J. Lagueux ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Signal Enhancement ◽  
Potential Toxicity ◽  
Mri Contrast

Ultra-small MnO nanoparticles pegylated with bis-phosphonate dendrons are efficient positive MRI contrast agents. They show prolonged vascular signal enhancement, followed by efficient excretion through the hepatobiliairy and urinary pathways. This considerably decreases the potential toxicity of MnO NPs.

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