scholarly journals Tailored biological retention and efficient clearance of pegylated ultra-small MnO nanoparticles as positive MRI contrast agents for molecular imaging

2014 ◽  
Vol 2 (13) ◽  
pp. 1779-1790 ◽  
Author(s):  
P. Chevallier ◽  
A. Walter ◽  
A. Garofalo ◽  
I. Veksler ◽  
J. Lagueux ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Signal Enhancement ◽  
Potential Toxicity ◽  
Mri Contrast

Ultra-small MnO nanoparticles pegylated with bis-phosphonate dendrons are efficient positive MRI contrast agents. They show prolonged vascular signal enhancement, followed by efficient excretion through the hepatobiliairy and urinary pathways. This considerably decreases the potential toxicity of MnO NPs.

scholarly journals Molecular imaging of atherosclerosis with nanoparticle-based fluorinated MRI contrast agents

Nanomedicine ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. 1817-1832 ◽  
Author(s):  
Rohun U Palekar ◽  
Andrew P Jallouk ◽  
Gregory M Lanza ◽  
Hua Pan ◽  
Samuel A Wickline
Keyword(s):  
Molecular Imaging ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast

scholarly journals Molecular imaging of EGFR/HER2 cancer biomarkers by protein MRI contrast agents

2013 ◽  
Vol 19 (2) ◽  
pp. 259-270 ◽  
Author(s):  
Jingjuan Qiao ◽  
Shenghui Xue ◽  
Fan Pu ◽  
Natalie White ◽  
Jie Jiang ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Contrast Agents ◽  
Cancer Biomarkers ◽  
Mri Contrast Agents ◽  
Mri Contrast

scholarly journals Biological effects of MRI contrast agents: gadolinium retention, potential mechanisms and a role for phosphorus

2017 ◽  
Vol 375 (2107) ◽  
pp. 20170180 ◽  
Author(s):  
Joel Garcia ◽  
Stephen Z. Liu ◽  
Angelique Y. Louie
Keyword(s):  
Molecular Imaging ◽  
Contrast Agents ◽  
Biological Effects ◽  
Blood Pool ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Treatment Regimens ◽  
Gadolinium Retention ◽  
Magnetic Resonance Imaging Mri ◽  
Blood Pool Agents

No discussion of challenges for chemistry in molecular imaging would be complete without addressing the elephant in the room—which is that the purest of chemical compounds needs to interact with a biological system in a manner that does not perturb normal biology while still providing efficacious feedback to assist in diagnosis of disease. In the past decade, magnetic resonance imaging (MRI) agents long considered inert have produced adverse effects in certain patient populations under certain treatment regimens. More recently, inert blood pool agents have been found to deposit in the brain. Release of free metal is often suspected as the culprit but that hypothesis has yet to be validated. In addition, even innocuous agents can cause painful side effects during injection in some patients. In this brief review, we summarize known biological effects for gadolinium- and iron-based MRI contrast agents, and discuss some of the potential mechanisms for the observed biological effects, including the potential role of phosphorus imbalance, related to kidney disease or cancer, in destabilizing gadolinium-based chelates and precipitating free gadolinium. This article is part of the themed issue ‘Challenges for chemistry in molecular imaging’.

scholarly journals Protein-Based MRI Contrast Agents for Molecular Imaging of Prostate Cancer

2010 ◽  
Vol 13 (3) ◽  
pp. 416-423 ◽  
Author(s):  
Lixia Wei ◽  
Shunyi Li ◽  
Jianhua Yang ◽  
Yiming Ye ◽  
Jin Zou ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Imaging ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast

scholarly journals Dynamic contrast enhanced MRI with clinical hepatospecific MRI contrast agents in pigs: initial experience

2020 ◽  
Author(s):  
Jeremy M.L. Hix ◽  
Christiane L. Mallett ◽  
Matthew Latourette ◽  
Kirk A. Munoz ◽  
Erik M. Shapiro
Keyword(s):  
Contrast Agent ◽  
Contrast Agents ◽  
Biomedical Imaging ◽  
Mri Contrast Agents ◽  
Signal Enhancement ◽  
Pig Liver ◽  
Mri Contrast ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

AbstractPigs are an important translational research model for biomedical imaging studies, and especially for modeling diseases of the liver. Dynamic contrast enhanced (DCE)-MRI is experimentally used to measure liver function in humans, but has never been characterized in pig liver. Here we performed DCE-MRI of pig liver following the delivery of two FDA approved hepato-specific MRI contrast agents, Gd-EOB-DTPA (Eovist) and Gd-BOPTA (Multihance), and the non-hepatospecific agent Magnevist, and optimized the anesthesia and animal handling protocol to acquire robust data. A single pig underwent 5 scanning sessions over six weeks, each time injected at clinical dosing either with Eovist (twice), Multihance (twice) or Magnevist (once). DCE-MRI was performed at 1.5T for 60 minutes. DCE-MRI showed rapid hepatic MRI signal enhancement following IV injection of Eovist or Multihance. Efflux of contrast agent from liver exhibited kinetics similar to that in humans, except for one hyperthermic animal where efflux was very fast. As expected, Magnevist was non-enhancing in the liver. The hepatic signal enhancement from Eovist matched that seen in humans and primates, while the hepatic signal enhancement from Multihance was different, similar to rodents and dogs, likely the result of differential hepatic organic anion transport polypeptides. This first experience with these agents in pigs provides valuable information on contrast agent dynamics in normal pig liver. Given the disparity in contrast agent uptake kinetics with humans for Multihance, Eovist should be used in porcine models for biomedical imaging. Proper animal health maintenance, especially temperature, seems essential for accurate and reproducible results.

Towards the Molecular Imaging of Prostate Cancer Biomarkers Using Protein-based MRI Contrast Agents

2016 ◽  
Vol 17 (6) ◽  
pp. 519-533 ◽  
Author(s):  
Fan Pu ◽  
Shenghui Xue ◽  
Jingjuan Qiao ◽  
Anvi Patel ◽  
Jenny J. Yang
Keyword(s):  
Prostate Cancer ◽  
Molecular Imaging ◽  
Contrast Agents ◽  
Cancer Biomarkers ◽  
Mri Contrast Agents ◽  
Mri Contrast
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