Amphiphilic copolymer coated upconversion nanoparticles for near-infrared light-triggered dual anticancer treatment

Nanoscale ◽  
2014 ◽  
Vol 6 (24) ◽  
pp. 14903-14910 ◽  
Author(s):  
Shun Yang ◽  
Najun Li ◽  
Zhuang Liu ◽  
Wenwei Sha ◽  
Dongyun Chen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Controlled Release ◽  
Cancer Cells ◽  
Self Assembly ◽  
Near Infrared ◽  
Amphiphilic Copolymer ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Assembly Process ◽  
Anticancer Treatment

The light-triggered controlled release of anticancer drugs accompanied with NIR-responsive photodynamic therapy was performed via a self-assembly process. Under 980 nm laser, the cancer cells could be effectively inhibited by released drugs and singlet oxygen simultaneously.

Near-infrared light-controlled drug release and cancer therapy with polymer-caged upconversion nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (7) ◽  
pp. 5269-5276 ◽  
Author(s):  
Qingjian Xing ◽  
Najun Li ◽  
Yang Jiao ◽  
Dongyun Chen ◽  
Jiaying Xu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Self Assembly ◽  
Near Infrared ◽  
Controlled Drug Release ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Assembly Process ◽  
The Core ◽  
Triggered Drug Release

The core–shell nanocarrier, based on spiropyran-containing copolymer coated upconversion nanocomposites, was successfully prepared via a facile self-assembly process for NIR-triggered drug release and cancer therapy.

Transferrin-coated magnetic upconversion nanoparticles for efficient photodynamic therapy with near-infrared irradiation and luminescence bioimaging

Nanoscale ◽  
2017 ◽  
Vol 9 (31) ◽  
pp. 11214-11221 ◽  
Author(s):  
Dan Wang ◽  
Lin Zhu ◽  
Yuan Pu ◽  
Jie-Xin Wang ◽  
Jian-Feng Chen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Magnetic Force ◽  
Near Infrared ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Infrared Irradiation ◽  
Near Infrared Light

A novel platform based on transferrin coated magnetic upconversion nanoparticles was developed for near-infrared light induced imaging and photodynamic therapy with enhanced efficiency by magnetic force.

scholarly journals Functionalized Upconversion Nanoparticles for Targeted Labelling of Bladder Cancer Cells

Biomolecules ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 820 ◽  
Author(s):  
Dmitry Polikarpov ◽  
Liuen Liang ◽  
Andrew Care ◽  
Anwar Sunna ◽  
Douglas Campbell ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Urothelial Carcinoma ◽  
Cancer Cells ◽  
Near Infrared ◽  
Carcinoma Cells ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Silica Layer ◽  
Bladder Cancer Cells

Bladder cancer is the ninth most common cancer worldwide. Due to a high risk of recurrence and progression of bladder cancer, every patient needs long-term surveillance, which includes regular cystoscopy, sometimes followed by a biopsy of suspicious lesions or resections of recurring tumours. This study addresses the development of novel biohybrid nanocomplexes representing upconversion nanoparticles (UCNP) coupled to antibodies for photoluminescent (PL) detection of bladder cancer cells. Carrying specific antibodies, these nanoconjugates selectively bind to urothelial carcinoma cells and make them visible by emitting visible PL upon excitation with deeply penetrating near-infrared light. UCNP were coated with a silica layer and linked to anti-Glypican-1 antibody MIL38 via silica-specific solid-binding peptide. Conjugates have been shown to specifically attach to urothelial carcinoma cells with high expression of Glypican-1. This result highlights the potential of produced conjugates and conjugation technology for further studies of their application in the tumour detection and fluorescence-guided resection.

Imaging-Guided pH-Sensitive Photodynamic Therapy Using Charge Reversible Upconversion Nanoparticles under Near-Infrared Light

2013 ◽  
Vol 23 (24) ◽  
pp. 3077-3086 ◽  
Author(s):  
Chao Wang ◽  
Liang Cheng ◽  
Yumeng Liu ◽  
Xiaojing Wang ◽  
Xinxing Ma ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Ph Sensitive ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Near Infrared Light

scholarly journals The Use of Upconversion Nanoparticles in Prostate Cancer Photodynamic Therapy

Life ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 360
Author(s):  
Michał Osuchowski ◽  
Filip Osuchowski ◽  
Wojciech Latos ◽  
Aleksandra Kawczyk-Krupka
Keyword(s):  
Prostate Cancer ◽  
Photodynamic Therapy ◽  
Near Infrared ◽  
Diagnostic Methods ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Visible Wavelengths ◽  
Intense Research

Photodynamic Therapy (PDT) is a cancer treatment that uses light, a photosensitizer, and oxygen to destroy tumors. This article is a review of approaches to the treatment of prostate cancer applying upconversion nanoparticles (UCNPs). UCNPs have become a phenomenon that are rapidly gaining recognition in medicine. They have proven to be highly selective and specific and present a powerful tool in the diagnosis and treatment of prostate cancer. Prostate cancer is a huge health problem in Western countries. Its early detection can significantly improve patients’ prognosis, but currently used diagnostic methods leave much to be desired. Recently developed methodologies regarding UCNP research between the years 2021 and 2014 for prostate cancer PDT will also be discussed. Current limitations in PDT include tissue irradiation with visible wavelengths that have a short tissue penetration depth. PDT with the objectives to synthesize UCNPs composed of a lanthanide core with a coating of adsorbed dye that will generate fluorescence after excitation with near-infrared light to illuminate deep tissue is a subject of intense research in prostate cancer.

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