scholarly journals Dual-modality, fluorescent, PLGA encapsulated bismuth nanoparticles for molecular and cellular fluorescence imaging and computed tomography

Nanoscale ◽  
2014 ◽  
Vol 6 (21) ◽  
pp. 13104-13112 ◽  
Author(s):  
Eric R. Swy ◽  
Aaron S. Schwartz-Duval ◽  
Dorela D. Shuboni ◽  
Matthew T. Latourette ◽  
Christiane L. Mallet ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Fluorescence Imaging ◽  
Cellular Imaging ◽  
Fluorescent Dye ◽  
X Ray ◽  
Dual Modality ◽  
Polymer Nanoparticle ◽  
Bismuth Nanoparticles

Bismuth nanocrystals and a fluorescent dye are encapsulated in a polymer nanoparticle, enabling dual fluorescent and x-ray molecular and cellular imaging.

Bismuth Nanoparticles with “Light” Property Served as a Multifunctional Probe for X-ray Computed Tomography and Fluorescence Imaging

2018 ◽  
Vol 30 (10) ◽  
pp. 3301-3307 ◽  
Author(s):  
Huiting Bi ◽  
Fei He ◽  
Yushan Dong ◽  
Dan Yang ◽  
Yunlu Dai ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Fluorescence Imaging ◽  
X Ray ◽  
Bismuth Nanoparticles ◽  
X Ray Computed

Dual-Modality Molecular Imaging for Small Animals Using Fluorescence and X-Ray Computed Tomography

2009 ◽  
Author(s):  
Yuting Lin ◽  
William C. Barber ◽  
Jan S. Iwanczk ◽  
Einar Nygard ◽  
Nail Malakov ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Molecular Imaging ◽  
Small Animals ◽  
X Ray ◽  
Dual Modality ◽  
X Ray Computed

Dual-modality molecular imaging for small animals using fluorescence and x-ray computed tomography

2009 ◽  
Author(s):  
Yuting Lin ◽  
William C. Barber ◽  
Jan S. Iwanczyk ◽  
Einar Nygard ◽  
Nail Malakov ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Molecular Imaging ◽  
Small Animals ◽  
X Ray ◽  
Dual Modality ◽  
X Ray Computed

scholarly journals Validation of an XCT/fDOT System on Mice

ISRN Optics ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Anne Koenig ◽  
Anne Planat-Chrétien ◽  
Kai Hassler ◽  
Martina Bucher ◽  
Jean-Guillaume Coutard ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Imaging System ◽  
Ex Vivo ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Cylindrical Geometry ◽  
X Ray ◽  
Dual Modality ◽  
X Ray Computed

In this paper we present systems for dual modality imaging, combining fluorescence-enhanced diffuse optical tomography and X-ray computed tomography. Fluorescence diffuse optical tomography is carried out in a cylindrical geometry, which ensures optimal sampling and a straight forward integration with the X-ray modality. Specific acquisition protocols and reconstruction software have been developed to this end. The X-ray computed tomography serves two purposes. First, it provides the anatomical information in the registered dual modality images. Second, it provides the actual shape and boundaries of the animal as a priori input to the fluorescence reconstruction algorithm. To evaluate the performance of the optical imaging system, experiments have been conducted on phantoms, mice with inserted fluorescing capillaries, and finally on mice bearing tumors, ex-vivo and in-vivo. Experiments on mice with capillaries inserted in different region of interest, allow estimating the detection limits of fluorophore concentrations. The fluorescence reconstructions are shown to be geometrically consistent with the X-ray images. Finally we demonstrate the capability of the bimodal system to localize real tumours in mice in-vivo. These results show that dual modality fluorescence-enhanced diffuse optical tomography and X-ray computed tomography imaging in cylindrical geometry has a high potential for small animal tumour evolution studies.

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