Folic Acid-Conjugated LaF3:Yb,Tm@SiO2 Nanoprobes for Targeting Dual-Modality Imaging of Upconversion Luminescence and X-ray Computed Tomography

2012 ◽  
Vol 116 (48) ◽  
pp. 14062-14070 ◽  
Author(s):  
Jiebing Ma ◽  
Peng Huang ◽  
Meng He ◽  
Liyuan Pan ◽  
Zhijun Zhou ◽  
...  
Author(s):  
Yuting Lin ◽  
William C. Barber ◽  
Jan S. Iwanczk ◽  
Einar Nygard ◽  
Nail Malakov ◽  
...  

2013 ◽  
Vol 11 (1) ◽  
pp. 17 ◽  
Author(s):  
Zhijun Zhou ◽  
Chunlei Zhang ◽  
Qirong Qian ◽  
Jiebing Ma ◽  
Peng Huang ◽  
...  

2009 ◽  
Author(s):  
Yuting Lin ◽  
William C. Barber ◽  
Jan S. Iwanczyk ◽  
Einar Nygard ◽  
Nail Malakov ◽  
...  

ISRN Optics ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Anne Koenig ◽  
Anne Planat-Chrétien ◽  
Kai Hassler ◽  
Martina Bucher ◽  
Jean-Guillaume Coutard ◽  
...  

In this paper we present systems for dual modality imaging, combining fluorescence-enhanced diffuse optical tomography and X-ray computed tomography. Fluorescence diffuse optical tomography is carried out in a cylindrical geometry, which ensures optimal sampling and a straight forward integration with the X-ray modality. Specific acquisition protocols and reconstruction software have been developed to this end. The X-ray computed tomography serves two purposes. First, it provides the anatomical information in the registered dual modality images. Second, it provides the actual shape and boundaries of the animal as a priori input to the fluorescence reconstruction algorithm. To evaluate the performance of the optical imaging system, experiments have been conducted on phantoms, mice with inserted fluorescing capillaries, and finally on mice bearing tumors, ex-vivo and in-vivo. Experiments on mice with capillaries inserted in different region of interest, allow estimating the detection limits of fluorophore concentrations. The fluorescence reconstructions are shown to be geometrically consistent with the X-ray images. Finally we demonstrate the capability of the bimodal system to localize real tumours in mice in-vivo. These results show that dual modality fluorescence-enhanced diffuse optical tomography and X-ray computed tomography imaging in cylindrical geometry has a high potential for small animal tumour evolution studies.


2016 ◽  
Vol 43 (1) ◽  
pp. 589-599 ◽  
Author(s):  
Anamaria Orza ◽  
Yi Yang ◽  
Ting Feng ◽  
Xueding Wang ◽  
Hui Wu ◽  
...  

1999 ◽  
Vol 11 (1) ◽  
pp. 199-211
Author(s):  
J. M. Winter ◽  
R. E. Green ◽  
A. M. Waters ◽  
W. H. Green

Sign in / Sign up

Export Citation Format

Share Document