Design, synthesis and metal sensing studies of ether-linked bis-triazole derivatives

2015 ◽  
Vol 39 (5) ◽  
pp. 3777-3784 ◽  
Author(s):  
Arasappan Hemamalini ◽  
Sathish Kumar Mudedla ◽  
Venkatesan Subramanian ◽  
Thangamuthu Mohan Das
Keyword(s):  
Click Reaction ◽  
Spectroscopic Techniques ◽  
Computational Studies ◽  
Design Synthesis ◽  
Triazole Derivatives ◽  
Metal Sensing

Ether-linked-bis-triazole derivatives have been synthesized by (CuAAC) “Click” reaction. Interaction of the compound with Hg2+has been demonstrated by various spectroscopic techniques which was further confirmed with computational studies.

Design, Synthesis, Evaluation and Computational Studies of Nipecotic Acid-Acetonaphthone Hybrids as Potential Antiepileptic Agents

2018 ◽  
Vol 14 (4) ◽  
pp. 409-426 ◽  
Author(s):  
Ankit Seth ◽  
Piyoosh A. Sharma ◽  
Avanish Tripathi ◽  
Priyanka K. Choubey ◽  
Pavan Srivastava ◽  
...  
Keyword(s):  
Computational Studies ◽  
Nipecotic Acid ◽  
Design Synthesis ◽  
Antiepileptic Agents

scholarly journals Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Tri-Aryl Imidazole-Benzene Sulfonamide Hybrids as Promising Selective Carbonic Anhydrase IX and XII Inhibitors

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4718
Author(s):  
Lamya H. Al-Wahaibi ◽  
Bahaa G. M. Youssif ◽  
Ehab S. Taher ◽  
Ahmed H. Abdelazeem ◽  
Antar A. Abdelhamid ◽  
...  
Keyword(s):  
Proliferative Activity ◽  
Docking Studies ◽  
Biological Evaluation ◽  
Selectivity Ratio ◽  
Computational Studies ◽  
Design Synthesis ◽  
Ca Ix ◽  
Side Pocket ◽  
Modelling Simulation ◽  
Good Agreement

A novel series of tri-aryl imidazole derivatives 5a–n carrying benzene sulfonamide moiety has been designed for their selective inhibitory against hCA IX and XII activity. Six compounds were found to be potent and selective CA IX inhibitors with the order of 5g > 5b > 5d > 5e > 5g > 5n (Ki = 0.3–1.3 μM, and selectivity ratio for hCA IX over hCA XII = 5–12) relative to acetazolamide (Ki = 0.03 μM, and selectivity ratio for hCA IX over hCA XII = 0.20). The previous sixth inhibitors have been further investigated for their anti-proliferative activity against four different cancer cell lines using MTT assay. Compounds 5g and 5b demonstrated higher antiproliferative activity than other tested compounds (with GI50 = 2.3 and 2.8 M, respectively) in comparison to doxorubicin (GI50 = 1.1 M). Docking studies of these two compounds adopted orientation and binding interactions with a higher liability to enter the active side pocket CA-IX selectively similar to that of ligand 9FK. Molecular modelling simulation showed good agreement with the acquired biological evaluation.

scholarly journals Fabrication of copper(II)-coated magnetic core-shell nanoparticles Fe3O4@SiO2-2-aminobenzohydrazide and investigation of its catalytic application in the synthesis of 1,2,3-triazole compounds

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
H. Rajabi-Moghaddam ◽  
M. R. Naimi-Jamal ◽  
M. Tajbakhsh
Keyword(s):  
High Efficiency ◽  
Click Reaction ◽  
Magnetic Core ◽  
Core Shell ◽  
Isatoic Anhydride ◽  
Shell Nanoparticles ◽  
Triazole Derivatives ◽  
Catalytic Application ◽  
Ft Ir ◽  
Core Shell Nanoparticles

AbstractIn the present work, an attempt has been made to synthesize the 1,2,3-triazole derivatives resulting from the click reaction, in a mild and green environment using the new copper(II)-coated magnetic core–shell nanoparticles Fe3O4@SiO2 modified by isatoic anhydride. The structure of the catalyst has been determined by XRD, FE-SEM, TGA, VSM, EDS, and FT-IR analyzes. The high efficiency and the ability to be recovered and reused for at least up to 6 consecutive runs are some superior properties of the catalyst.

scholarly journals Design, Synthesis and Inhibitory Properties against Coxsackie B3/B6 of Some Novel Triazole Derivatives

2013 ◽  
Vol 03 (01) ◽  
pp. 41-46 ◽  
Author(s):  
Dongping Shao ◽  
Yanbing Yang ◽  
Fei Xue ◽  
Xianjin Luo ◽  
Reyila Wubulikasimu ◽  
...  
Keyword(s):  
Design Synthesis ◽  
Triazole Derivatives

ChemInform Abstract: Novel Sesquiterpenes from Schisandra grandiflora: Isolation, Cytotoxic Activity and Synthesis of Their Triazole Derivatives Using “click” Reaction.

ChemInform ◽  
2015 ◽  
Vol 46 (26) ◽  
pp. no-no
Author(s):  
B. Poornima ◽  
Bandi Siva ◽  
G. Shankaraiah ◽  
A. Venkanna ◽  
V. Lakshma Nayak ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Click Reaction ◽  
Triazole Derivatives
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