scholarly journals Design, Synthesis and Inhibitory Properties against Coxsackie B3/B6 of Some Novel Triazole Derivatives

2013 ◽  
Vol 03 (01) ◽  
pp. 41-46 ◽  
Author(s):  
Dongping Shao ◽  
Yanbing Yang ◽  
Fei Xue ◽  
Xianjin Luo ◽  
Reyila Wubulikasimu ◽  
...  
Keyword(s):  
Design Synthesis ◽  
Triazole Derivatives

scholarly journals Design, synthesis, and in vitro antifungal evaluation of novel triazole derivatives bearing alkynyl side chains

2019 ◽  
Vol 23 (5) ◽  
pp. 576-585 ◽  
Author(s):  
Tingjunhong Ni ◽  
Lei Pang ◽  
Zhan Cai ◽  
Fei Xie ◽  
Zichao Ding ◽  
...  
Keyword(s):  
Side Chains ◽  
Design Synthesis ◽  
Triazole Derivatives

scholarly journals Design, Synthesis and Fungicidal Activity of New 1,2,4-Triazole Derivatives Containing Oxime Ether and Phenoxyl Pyridinyl Moiety

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5852
Author(s):  
Hui Bai ◽  
Xuelian Liu ◽  
Pengfei Chenzhang ◽  
Yumei Xiao ◽  
Bin Fu ◽  
...  
Keyword(s):  
High Resolution Mass Spectrometry ◽  
Binding Modes ◽  
Oxime Ether ◽  
Single Crystal Diffraction ◽  
Design Synthesis ◽  
Antifungal Activities ◽  
Triazole Derivatives ◽  
Pyridine Moiety ◽  
New Compounds

A series of novel 1,2,4-triazole derivatives containing oxime ether and phenoxy pyridine moiety were designed and synthesized. The new compounds were identified by nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HRMS). Compound (Z)-1-(6-(4-nitrophenoxy)pyridin-3-yl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one O-methyl oxime (5a18) was further confirmed by X-ray single crystal diffraction. Their antifungal activities were evaluated against eight phytopathogens. The in vitro bioassays indicated that most of the title compounds displayed moderate to high fungicidal activities. Compound (Z)-1-(6-(4-bromo-2-chlorophenoxy)pyridin-3-yl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one O-methyl oxime (5a4) exhibited a broad-spectrum antifungal activities with the EC50 values of 1.59, 0.46, 0.27 and 11.39 mg/L against S. sclerotiorum, P. infestans, R. solani and B. cinerea, respectively. Compound (Z)-1-(6-(2-chlorophenoxy)pyridin-3-yl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one O-benzyl oxime (5b2) provided the lowest EC50 value of 0.12 mg/L against S. sclerotiorum, which were comparable to the commercialized difenoconazole. Moreover, homologous modeling and molecular docking disclosed possible binding modes of compounds 5a4 and 5b2 with CYP51. This work provided useful guidance for the discovery of new 1,2,4-triazole fungicides.

Design, synthesis and in vitro anti-tuberculosis activity of benzo[6,7]cyclohepta[1,2- b ]pyridine-1,2,3-triazole derivatives

2017 ◽  
Vol 27 (23) ◽  
pp. 5119-5121 ◽  
Author(s):  
Yasodakrishna Sajja ◽  
Sowmya Vanguru ◽  
Hanmanth Reddy Vulupala ◽  
Rajashaker Bantu ◽  
Perumal Yogeswari ◽  
...  
Keyword(s):  
Design Synthesis ◽  
Triazole Derivatives ◽  
Tuberculosis Activity

Design, Synthesis, and Molecular Docking Studies of Pyrazine Containing 1,2,3-Triazole Derivatives

2016 ◽  
Vol 54 (2) ◽  
pp. 1492-1505
Author(s):  
Radhakrishnam Raju Ruddarraju ◽  
Adharvana Chari Murugulla ◽  
Ravindar Kotla ◽  
Muni Chandra Babu Tirumalasetty ◽  
Rajendra Wudayagiri ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Docking Studies ◽  
Design Synthesis ◽  
Triazole Derivatives ◽  
Molecular Docking Studies

Design, Synthesis, and Biological Evaluation of New Indole-Acrylamide-1,2,3-Triazole Derivatives as Potential α-Glucosidase Inhibitors

2020 ◽  
pp. 1-9
Author(s):  
Seyed Esmaeil Sadat-Ebrahimi ◽  
Hiva Babania ◽  
Maryam Mohammadi-Khanaposhtani ◽  
Mohammad Sadegh Asgari ◽  
Somayeh Mojtabavi ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Triazole Derivatives ◽  
Glucosidase Inhibitors ◽  
Synthesis And Biological Evaluation

Design, synthesis and fungicidal activity of novel strobilurin-1,2,4-triazole derivatives containing furan or thiophene rings

2016 ◽  
Vol 32 (6) ◽  
pp. 952-958 ◽  
Author(s):  
Yang Liu ◽  
Ming Liu ◽  
Dongkai Zhang ◽  
Xuewen Hua ◽  
Baolei Wang ◽  
...  
Keyword(s):  
Fungicidal Activity ◽  
Design Synthesis ◽  
Triazole Derivatives
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