Nucleoside bearing boron clusters and their phosphoramidites – building blocks for modified oligonucleotide synthesis

2015 ◽  
Vol 39 (2) ◽  
pp. 1202-1221 ◽  
Author(s):  
Michał Matuszewski ◽  
Agnieszka Kiliszek ◽  
Wojciech Rypniewski ◽  
Zbigniew J. Lesnikowski ◽  
Agnieszka B. Olejniczak
Keyword(s):  
Building Blocks ◽  
Electrochemical Characteristics ◽  
Oligonucleotide Synthesis ◽  
X Ray ◽  
Boron Cluster ◽  
Boron Clusters ◽  
Modified Oligonucleotide

Synthesis of four canonical nucleoside-closo-/nido-carborane conjugates, their phosphoramidites, their electrochemical characteristics and the first example of the X-ray structure of a nucleoside-boron cluster conjugate.

Boron clusters as a platform for new materials: composites of nucleic acids and oligofunctionalized carboranes (C2B10H12) and their assembly into functional nanoparticles

Nanoscale ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 103-114 ◽  
Author(s):  
Damian Kaniowski ◽  
Katarzyna Ebenryter-Olbinska ◽  
Katarzyna Kulik ◽  
Slawomir Janczak ◽  
Anna Maciaszek ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nucleic Acids ◽  
Gene Expression Regulation ◽  
Therapeutic Potential ◽  
Building Blocks ◽  
New Materials ◽  
Boron Cluster ◽  
Boron Clusters ◽  
Functional Nanoparticles ◽  
Dual Action

The building blocks based on boron cluster spanning two short DNA adapters assemble into functional nanoparticles due to the formation of DNA helices. They offer dual-action therapeutic potential, e.g., in the BNCT and gene expression regulation.

Axially Chiral Bis(α-amino Acid)s and Their Deamino Analogues. Synthesis and Configurational Assignment

1998 ◽  
Vol 63 (2) ◽  
pp. 211-221 ◽  
Author(s):  
Miloš Tichý ◽  
Luděk Ridvan ◽  
Miloš Buděšínský ◽  
Jiří Závada ◽  
Jaroslav Podlaha ◽  
...  
Keyword(s):  
Amino Acid ◽  
Nmr Spectra ◽  
Building Blocks ◽  
X Ray Diffraction ◽  
Amino Groups ◽  
X Ray ◽  
Configurational Assignment ◽  
Symmetry Properties ◽  
Axially Chiral ◽  
Polymeric Structures

The axially chiral bis(α-amino acid)s cis-2 and trans-2 as possible building blocks for polymeric structures of novel type of helicity were prepared. Their configuration has been determined by NMR spectroscopy and, in the case of the trans-isomer, confirmed by single-crystal X-ray diffraction. Analogous pair of stereoisomeric diacids cis-3 and trans-3, devoid of the amino groups, was also prepared and their configuration assigned. The observed differences in the NMR spectra of cis- and trans-isomers of 2 and 3 are discussed from the viewpoint of their different symmetry properties.

Fully Automated Parallel Oligonucleotide Synthesizer

2001 ◽  
Vol 66 (8) ◽  
pp. 1299-1314 ◽  
Author(s):  
Michal Lebl ◽  
Christine Burger ◽  
Brett Ellman ◽  
David Heiner ◽  
Georges Ibrahim ◽  
...  
Keyword(s):  
Solid Phase ◽  
Building Blocks ◽  
Solid Support ◽  
Continuous Operation ◽  
Gear Pump ◽  
Oligonucleotide Synthesis ◽  
Center Of Rotation ◽  
Microtiter Plates ◽  
The Individual ◽  
Design And Construction

Design and construction of automated synthesizers using the tilted plate centrifugation technology is described. Wash solutions and reagents common to all synthesized species are delivered automatically through a 96-channel distributor connected to a gear pump through two four-port selector valves. Building blocks and other specific reagents are delivered automatically through banks of solenoid valves, positioned over the individual wells of the microtiterplate. These instruments have the following capabilities: Parallel solid-phase oligonucleotide synthesis in the wells of polypropylene microtiter plates, which are slightly tilted down towards the center of rotation, thus generating a pocket in each well, in which the solid support is collected during centrifugation, while the liquid is expelled from the wells. Eight microtiterplates are processed simultaneously, providing thus a synthesizer with a capacity of 768 parallel syntheses. The instruments are capable of unattended continuous operation, providing thus a capacity of over two millions 20-mer oligonucleotides in a year.

A New POM-Based Supramolecular Compound: Synthesis, Structure and Adsorptive Property of [Cu(phen)2]3[W6O19]

2014 ◽  
Vol 919-921 ◽  
pp. 2013-2016 ◽  
Author(s):  
Ya Bing Liu ◽  
Hong Jie Wang ◽  
Hong Kai Zhao
Keyword(s):  
Three Dimensional ◽  
Building Blocks ◽  
Monoclinic Space Group ◽  
X Ray Diffraction ◽  
Hybrid Compound ◽  
Adsorptive Property ◽  
X Ray ◽  
Hydrogen Bonding Interactions ◽  
Compound Synthesis ◽  
Metal Organic

A POM - based organice - inorganic hybrid compound with the chemical formula of[Cu (phen)2]3[W6O19] (phen = 1,10-phenanthroline) (1) has been hydrothermally synthesized andstructurally characterized by the elemental analysis, and single crystal X-ray diffraction. Compound 1 crystallizes in the monoclinic space groupC2/c witha=18.319(4) Å,b= 17.311(4) Å,c= 22.248(4) Å,β= 112.40(3) o,V= 6523(2) Å3,Z= 4, R1= 0.0448, andwR2=0.1218. Compound 1 consists of the [W6O19]3-building blocks and [Cu (phen)2]+metal organic cationic moieties, which are packed together via the extensive hydrogen-bonding interactions to form a three-dimensional supramolecular framework. The adsorption of methylene blue (MB) under UV irradiation with 1 as the heterogeneous adsorbent has been investigated, showing a good adsorptive property of 1 for MB degradation.

ChemInform Abstract: Dimeric Building Blocks with N-Cyanoguanidine Linkage for Oligonucleotide Synthesis.

ChemInform ◽  
2010 ◽  
Vol 24 (18) ◽  
pp. no-no
Author(s):  
C. PANNECOUQUE ◽  
P. WIGERINCK ◽  
A. VAN AERSCHOT ◽  
P. HERDEWIJN
Keyword(s):  
Building Blocks ◽  
Oligonucleotide Synthesis

Neue Cyclophosphazene mit Metallen der III. Hauptgruppe als Ringbausteine / New Cyclophosphazenes with Metals of Main Group III as Building Blocks

1994 ◽  
Vol 49 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Reinhard Hasselbring ◽  
Herbert W. Roesky ◽  
Andreas Heine ◽  
Dietmar Stalke ◽  
George M. Sheldrick
Keyword(s):  
Nmr Spectroscopy ◽  
Structure Determination ◽  
Building Blocks ◽  
Main Group ◽  
Ring Formation ◽  
Lewis Acidity ◽  
X Ray ◽  
Group Iii ◽  
Space Groups ◽  
Ring Compounds

Abstract Acylic silylated phosphazenes of the type HN(PR2NSiMe3)2 (1) react quantitatively with molecules MMe3 (M = Al, Ga, In) under ring formation and CH4 evolution. The ring compounds N(PPh2NSiMe3)2AlMe2 (2 a) and N(PPh2NSiMe3)2InMe2 (4 a) have been investiga­ ted by X-ray structure determination. 2a and 4a crystallize in the space groups P 1̄ and P 31, respectively; they show different conformations regarding the cyclohexane framework. NMR spectroscopy of the nuclei in the chelating phosphazene ligand indicates decreasing Lewis acidity of the metal containing fragments in the series AlMe2 ≥ GaMe2 > InMe2.

scholarly journals Synthesis of Protected Amino Hexitol Nucleosides as Building Blocks for Oligonucleotide Synthesis

2018 ◽  
Vol 83 (24) ◽  
pp. 15155-15169 ◽  
Author(s):  
Swarup De ◽  
Amit M. Jabgunde ◽  
Rahul S. Patil ◽  
Steven De Jonghe ◽  
Leonid Beigelman ◽  
...  
Keyword(s):  
Building Blocks ◽  
Oligonucleotide Synthesis

Fractal aggregates of lanthanide-doped Y2O3 nanoparticles obtained by propellant synthesis

2001 ◽  
Vol 16 (1) ◽  
pp. 146-154 ◽  
Author(s):  
Stefano Polizzi ◽  
Giuliano Fagherazzi ◽  
Marino Battagliarin ◽  
Marco Bettinelli ◽  
Adolfo Speghini
Keyword(s):  
Building Blocks ◽  
Compositional Gradient ◽  
Fractal Aggregates ◽  
Scaling Properties ◽  
X Ray ◽  
Lattice Disorder ◽  
Average Value ◽  
X Ray Scattering ◽  
20 Nm ◽  
Ray Scattering

Y2-xLnxO3 (Ln 4 Ce, Pr, Nd, Eu, Gd, Ho, and Er) powders obtained by propellant synthesis have been characterized using small-angle x-ray scattering, wide-angle x-ray scattering, and transmission and scanning electron microscopy. All the samples showed a very porous, open microstructure with fractal scaling properties. The building blocks of the fractal aggregates are nanocrystallites of lanthanide-doped Y2O3, with variations in the cubic lattice constant proportional to the composition of the solid solution and to the lanthanide ionic radius. The particles had a narrow distribution of sizes with an average value in the 20–50 nm range. They are made of a core of 10–20 nm, consisting of almost perfectly ordered crystals and a “fuzzy” layer, characterized by either a growing lattice disorder or by a compositional gradient. From this dimension, up to at least 200 nm, the particle aggregate is a mass fractal with a fractal dimension, DMf, in the 1.6–2.0 range.

scholarly journals Iron(II) Complexes with Boron Cluster Anion [B10Cl10]2-: Intermolecular Interactions according to35Cl NQR Spectroscopy and X-ray Diffraction

2017 ◽  
Vol 643 (23) ◽  
pp. 1939-1947 ◽  
Author(s):  
Eleonora A. Kravchenko ◽  
Andrei. A. Gippius ◽  
Irina N. Polyakova† ◽  
Varvara V. Avdeeva ◽  
Elena A. Malinina ◽  
...  
Keyword(s):  
Intermolecular Interactions ◽  
Cluster Anion ◽  
X Ray Diffraction ◽  
X Ray ◽  
Boron Cluster ◽  
Boron Cluster Anion
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