scholarly journals Synthesis of Protected Amino Hexitol Nucleosides as Building Blocks for Oligonucleotide Synthesis

2018 ◽  
Vol 83 (24) ◽  
pp. 15155-15169 ◽  
Author(s):  
Swarup De ◽  
Amit M. Jabgunde ◽  
Rahul S. Patil ◽  
Steven De Jonghe ◽  
Leonid Beigelman ◽  
...  
Keyword(s):  
Building Blocks ◽  
Oligonucleotide Synthesis

Fully Automated Parallel Oligonucleotide Synthesizer

2001 ◽  
Vol 66 (8) ◽  
pp. 1299-1314 ◽  
Author(s):  
Michal Lebl ◽  
Christine Burger ◽  
Brett Ellman ◽  
David Heiner ◽  
Georges Ibrahim ◽  
...  
Keyword(s):  
Solid Phase ◽  
Building Blocks ◽  
Solid Support ◽  
Continuous Operation ◽  
Gear Pump ◽  
Oligonucleotide Synthesis ◽  
Center Of Rotation ◽  
Microtiter Plates ◽  
The Individual ◽  
Design And Construction

Design and construction of automated synthesizers using the tilted plate centrifugation technology is described. Wash solutions and reagents common to all synthesized species are delivered automatically through a 96-channel distributor connected to a gear pump through two four-port selector valves. Building blocks and other specific reagents are delivered automatically through banks of solenoid valves, positioned over the individual wells of the microtiterplate. These instruments have the following capabilities: Parallel solid-phase oligonucleotide synthesis in the wells of polypropylene microtiter plates, which are slightly tilted down towards the center of rotation, thus generating a pocket in each well, in which the solid support is collected during centrifugation, while the liquid is expelled from the wells. Eight microtiterplates are processed simultaneously, providing thus a synthesizer with a capacity of 768 parallel syntheses. The instruments are capable of unattended continuous operation, providing thus a capacity of over two millions 20-mer oligonucleotides in a year.

ChemInform Abstract: Dimeric Building Blocks with N-Cyanoguanidine Linkage for Oligonucleotide Synthesis.

ChemInform ◽  
2010 ◽  
Vol 24 (18) ◽  
pp. no-no
Author(s):  
C. PANNECOUQUE ◽  
P. WIGERINCK ◽  
A. VAN AERSCHOT ◽  
P. HERDEWIJN
Keyword(s):  
Building Blocks ◽  
Oligonucleotide Synthesis

Nucleoside 3′-N,N-dialkylphosphonamidates: novel building blocks for oligonucleotide synthesis

1990 ◽  
Vol 31 (44) ◽  
pp. 6363-6366 ◽  
Author(s):  
Takeshi Wada ◽  
Kazushige Ishikawa ◽  
Tsujiaki Hata
Keyword(s):  
Building Blocks ◽  
Oligonucleotide Synthesis

scholarly journals Synthesis of 1,5‐Anhydrohexitol Building Blocks for Oligonucleotide Synthesis

2003 ◽  
Vol 14 (1) ◽  
Author(s):  
Irene M. Lagoja ◽  
Arnaud Marchand ◽  
Arthur Aerschot ◽  
Piet Herdewijn
Keyword(s):  
Building Blocks ◽  
Oligonucleotide Synthesis

Fast identification by FAB-mass spectrometry of building blocks for oligonucleotide synthesis

1984 ◽  
Vol 25 (47) ◽  
pp. 5373-5376 ◽  
Author(s):  
Lutz Grotjahn ◽  
Ronald Frank ◽  
Gudrun Heisterberg-Moutsis ◽  
Helmut Blöcker
Keyword(s):  
Mass Spectrometry ◽  
Building Blocks ◽  
Oligonucleotide Synthesis ◽  
Fast Identification ◽  
Fab Mass Spectrometry

HPLC electrospray mass spectrometric characterization of trimeric building blocks for oligonucleotide synthesis

2004 ◽  
Vol 34 (1) ◽  
pp. 199-206 ◽  
Author(s):  
Timo Mauriala ◽  
Seppo Auriola ◽  
Alex Azhayev ◽  
Alexei Kayushin ◽  
Maria Korosteleva ◽  
...  
Keyword(s):  
Building Blocks ◽  
Mass Spectrometric ◽  
Oligonucleotide Synthesis
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