Ruthenium polypyridyl complexes as inducer of ROS-mediated apoptosis in cancer cells by targeting thioredoxin reductase

Metallomics ◽  
2014 ◽  
Vol 6 (8) ◽  
pp. 1480-1490 ◽  
Author(s):  
Zuandi Luo ◽  
Lianling Yu ◽  
Fang Yang ◽  
Zhennan Zhao ◽  
Bo Yu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Apoptosis ◽  
Thioredoxin Reductase ◽  
Cancer Growth ◽  
Ros Generation ◽  
Ruthenium Polypyridyl ◽  
Polypyridyl Complexes ◽  
Intracellular Ros ◽  
Ruthenium Polypyridyl Complexes ◽  
Apoptosis In Cancer Cells

Ruthenium polypyridyl complexes inhibit cancer growth by targeting TrxR and promote the intracellular ROS generation, ultimately triggering mitochondria-mediated cell apoptosis.

Ruthenium Polypyridyl Complexes That Induce Mitochondria-Mediated Apoptosis in Cancer Cells

2010 ◽  
Vol 49 (14) ◽  
pp. 6366-6368 ◽  
Author(s):  
Tianfeng Chen ◽  
Yanan Liu ◽  
Wen-Jie Zheng ◽  
Jie Liu ◽  
Yum-Shing Wong
Keyword(s):  
Cancer Cells ◽  
Ruthenium Polypyridyl ◽  
Polypyridyl Complexes ◽  
Ruthenium Polypyridyl Complexes ◽  
Apoptosis In Cancer Cells

Mixed-ligand ruthenium polypyridyl complexes as apoptosis inducers in cancer cells, the cellular translocation and the important role of ROS-mediated signaling

2014 ◽  
Vol 43 (45) ◽  
pp. 17017-17028 ◽  
Author(s):  
Zhennan Zhao ◽  
Zuandi Luo ◽  
Qiong Wu ◽  
Wenjie Zheng ◽  
Yanxian Feng ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Ruthenium Complexes ◽  
Mixed Ligand ◽  
Ruthenium Polypyridyl ◽  
Polypyridyl Complexes ◽  
Cellular Translocation ◽  
Ruthenium Polypyridyl Complexes

Ruthenium complexes enter cancer cells through TfR-mediated endocytosis and translocate to the mitochondria, where they activate ROS-mediated apoptosis.

Influence of the Attaching Group and Substituted Position in the Photosensitization Behavior of Ruthenium Polypyridyl Complexes

1999 ◽  
Vol 38 (26) ◽  
pp. 6320-6322 ◽  
Author(s):  
Yuan-jun Hou ◽  
Pu-hui Xie ◽  
Bao-wen Zhang ◽  
Yi Cao ◽  
Xu-rui Xiao ◽  
...  
Keyword(s):  
Ruthenium Polypyridyl ◽  
Polypyridyl Complexes ◽  
Ruthenium Polypyridyl Complexes

CYT-Rx20 Inhibits Cervical Cancer Cell Growth and Migration Through Oxidative Stress-Induced DNA Damage, Cell Apoptosis, and Epithelial-to-Mesenchymal Transition Inhibition

2017 ◽  
Vol 27 (7) ◽  
pp. 1306-1317
Author(s):  
Yen-Yun Wang ◽  
Pei-Wen Hsieh ◽  
Yuk-Kwan Chen ◽  
Stephen Chu-Sung Hu ◽  
Ya-Ling Hsu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Dna Damage ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Cervical Cancer Cell ◽  
Ros Generation ◽  
Mesenchymal Transition ◽  
Cervical Cancer Cells

ObjectiveThe β-nitrostyrene family has been reported to possess anticancer properties. However, the anticancer activity of β-nitrostyrenes on cervical cancer cells and the underlying mechanisms involved remain unexplored. In this study, a β-nitrostyrene derivative CYT-Rx20 (3′-hydroxy-4′-methoxy-β-methyl-β-nitrostyrene) was synthesized, and its anticancer activity on cervical cancer cells and the mechanisms involved were investigated.MethodsThe effect of CYT-Rx20 on human cervical cancer cell growth was evaluated using cell viability assay. Reactive oxygen species (ROS) generation and annexin V staining were detected by flow cytometry. The protein expression levels of cleaved caspase-3, cleaved caspase-9, cleaved poly (ADPribose) polymerase, γH2AX, β-catenin, Vimentin, and Twist were measured by Western blotting. DNA double-strand breaks were determined by γ-H2AX foci formation and neutral comet assay. Migration assay was used to determine cancer cell migration. Nude mice xenograft was used to investigate the antitumor effects of CYT-Rx20 in vivo.ResultsCYT-Rx20 induced cytotoxicity in cervical cancer cells by promoting cell apoptosis via ROS generation and DNA damage. CYT-Rx20-induced cell apoptosis, ROS generation, and DNA damage were reversed by thiol antioxidants. In addition, CYT-Rx20 inhibited cervical cancer cell migration by regulating the expression of epithelial-to-mesenchymal transition markers. In nude mice, CYT-Rx20 inhibited cervical tumor growth accompanied by increased expression of DNA damage marker γH2AX and decreased expression of mesenchymal markers β-catenin and Twist.ConclusionsCYT-Rx20 inhibits cervical cancer cells in vitro and in vivo and has the potential to be further developed into an anti-cervical cancer drug clinically.

Modulation of Internuclear Communication in Multinuclear Ruthenium(II) Polypyridyl Complexes

2003 ◽  
Vol 68 (8) ◽  
pp. 1467-1487 ◽  
Author(s):  
Wesley R. Browne ◽  
Frances Weldon ◽  
Adrian Guckian ◽  
Johannes G. Vos
Keyword(s):  
Ground State ◽  
Weak Interactions ◽  
Electrochemical Studies ◽  
Protonation State ◽  
Ruthenium Polypyridyl ◽  
Bridging Ligands ◽  
Polypyridyl Complexes ◽  
Bridging Ligand ◽  
Dinuclear Ruthenium ◽  
Ruthenium Polypyridyl Complexes

The syntheses and characterisation of a series of mononuclear and dinuclear ruthenium polypyridyl complexes based on the bridging ligands 1,3-bis-[5-(2-pyridyl)-1H-1,2,4-triazol-3-yl]benzene, 1,4-bis-[5-(2-pyridyl)-1H-1,2,4-triazol-3-yl]benzene, 2,5-bis-[5-(2-pyridyl)-1H-1,2,4-triazol-3-yl]thiophene, 2,5-bis-[5-pyrazinyl-1H-1,2,4-triazol-3-yl]thiophene are reported. Electrochemical studies indicate that in these systems, the ground state interaction is critically dependent on the nature of the bridging ligand and its protonation state, with strong and weak interactions being observed for thiophene- and phenylene-bridged complexes, respectively.

scholarly journals Quantitative description of MLCT transitions in ruthenium polypyridyl complexes probed by two-photon absorption spectroscopy

2018 ◽  
Vol 190 ◽  
pp. 03012
Author(s):  
Charles W. Stark ◽  
M. Rammo ◽  
K. Petritšenko ◽  
J. Pahapill ◽  
A. Mikhaylov ◽  
...  
Keyword(s):  
Cross Section ◽  
Quantitative Description ◽  
Photon Absorption ◽  
Charge Transfer Transition ◽  
Ruthenium Polypyridyl ◽  
Polypyridyl Complexes ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Ligand Charge Transfer ◽  
Ruthenium Polypyridyl Complexes

Quantitative two-photon absorption (2PA) cross section and 2PA spectrum measurements were used to determine the molecular electric dipole change in the metal-to-ligand charge-transfer transition of ruthenium(II) tris-complexes of 2,2’-bipyridine ([Ru(bpy)3]2+) and 1,10-phenanthroline ([Ru(phen)3]2+) in several solvents.

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