Mixed-ligand ruthenium polypyridyl complexes as apoptosis inducers in cancer cells, the cellular translocation and the important role of ROS-mediated signaling

2014 ◽  
Vol 43 (45) ◽  
pp. 17017-17028 ◽  
Author(s):  
Zhennan Zhao ◽  
Zuandi Luo ◽  
Qiong Wu ◽  
Wenjie Zheng ◽  
Yanxian Feng ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Ruthenium Complexes ◽  
Mixed Ligand ◽  
Ruthenium Polypyridyl ◽  
Polypyridyl Complexes ◽  
Cellular Translocation ◽  
Ruthenium Polypyridyl Complexes

Ruthenium complexes enter cancer cells through TfR-mediated endocytosis and translocate to the mitochondria, where they activate ROS-mediated apoptosis.

Ruthenium polypyridyl complexes as inducer of ROS-mediated apoptosis in cancer cells by targeting thioredoxin reductase

Metallomics ◽  
2014 ◽  
Vol 6 (8) ◽  
pp. 1480-1490 ◽  
Author(s):  
Zuandi Luo ◽  
Lianling Yu ◽  
Fang Yang ◽  
Zhennan Zhao ◽  
Bo Yu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Apoptosis ◽  
Thioredoxin Reductase ◽  
Cancer Growth ◽  
Ros Generation ◽  
Ruthenium Polypyridyl ◽  
Polypyridyl Complexes ◽  
Intracellular Ros ◽  
Ruthenium Polypyridyl Complexes ◽  
Apoptosis In Cancer Cells

Ruthenium polypyridyl complexes inhibit cancer growth by targeting TrxR and promote the intracellular ROS generation, ultimately triggering mitochondria-mediated cell apoptosis.

Ruthenium Polypyridyl Complexes That Induce Mitochondria-Mediated Apoptosis in Cancer Cells

2010 ◽  
Vol 49 (14) ◽  
pp. 6366-6368 ◽  
Author(s):  
Tianfeng Chen ◽  
Yanan Liu ◽  
Wen-Jie Zheng ◽  
Jie Liu ◽  
Yum-Shing Wong
Keyword(s):  
Cancer Cells ◽  
Ruthenium Polypyridyl ◽  
Polypyridyl Complexes ◽  
Ruthenium Polypyridyl Complexes ◽  
Apoptosis In Cancer Cells

Influence of the Attaching Group and Substituted Position in the Photosensitization Behavior of Ruthenium Polypyridyl Complexes

1999 ◽  
Vol 38 (26) ◽  
pp. 6320-6322 ◽  
Author(s):  
Yuan-jun Hou ◽  
Pu-hui Xie ◽  
Bao-wen Zhang ◽  
Yi Cao ◽  
Xu-rui Xiao ◽  
...  
Keyword(s):  
Ruthenium Polypyridyl ◽  
Polypyridyl Complexes ◽  
Ruthenium Polypyridyl Complexes

Modulation of Internuclear Communication in Multinuclear Ruthenium(II) Polypyridyl Complexes

2003 ◽  
Vol 68 (8) ◽  
pp. 1467-1487 ◽  
Author(s):  
Wesley R. Browne ◽  
Frances Weldon ◽  
Adrian Guckian ◽  
Johannes G. Vos
Keyword(s):  
Ground State ◽  
Weak Interactions ◽  
Electrochemical Studies ◽  
Protonation State ◽  
Ruthenium Polypyridyl ◽  
Bridging Ligands ◽  
Polypyridyl Complexes ◽  
Bridging Ligand ◽  
Dinuclear Ruthenium ◽  
Ruthenium Polypyridyl Complexes

The syntheses and characterisation of a series of mononuclear and dinuclear ruthenium polypyridyl complexes based on the bridging ligands 1,3-bis-[5-(2-pyridyl)-1H-1,2,4-triazol-3-yl]benzene, 1,4-bis-[5-(2-pyridyl)-1H-1,2,4-triazol-3-yl]benzene, 2,5-bis-[5-(2-pyridyl)-1H-1,2,4-triazol-3-yl]thiophene, 2,5-bis-[5-pyrazinyl-1H-1,2,4-triazol-3-yl]thiophene are reported. Electrochemical studies indicate that in these systems, the ground state interaction is critically dependent on the nature of the bridging ligand and its protonation state, with strong and weak interactions being observed for thiophene- and phenylene-bridged complexes, respectively.

scholarly journals Quantitative description of MLCT transitions in ruthenium polypyridyl complexes probed by two-photon absorption spectroscopy

2018 ◽  
Vol 190 ◽  
pp. 03012
Author(s):  
Charles W. Stark ◽  
M. Rammo ◽  
K. Petritšenko ◽  
J. Pahapill ◽  
A. Mikhaylov ◽  
...  
Keyword(s):  
Cross Section ◽  
Quantitative Description ◽  
Photon Absorption ◽  
Charge Transfer Transition ◽  
Ruthenium Polypyridyl ◽  
Polypyridyl Complexes ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Ligand Charge Transfer ◽  
Ruthenium Polypyridyl Complexes

Quantitative two-photon absorption (2PA) cross section and 2PA spectrum measurements were used to determine the molecular electric dipole change in the metal-to-ligand charge-transfer transition of ruthenium(II) tris-complexes of 2,2’-bipyridine ([Ru(bpy)3]2+) and 1,10-phenanthroline ([Ru(phen)3]2+) in several solvents.

Sixty Years Young: The Diverse Biological Activities of Metal Polypyridyl Complexes Pioneered by Francis P. Dwyer

2012 ◽  
Vol 65 (9) ◽  
pp. 1325 ◽  
Author(s):  
Nathan L. Kilah ◽  
Eric Meggers
Keyword(s):  
Inorganic Chemistry ◽  
Biological Activities ◽  
Biologically Active ◽  
Ruthenium Polypyridyl ◽  
Polypyridyl Complexes ◽  
Anti Cancer ◽  
Ruthenium Polypyridyl Complexes ◽  
Medicinal Inorganic Chemistry ◽  
Sixtieth Anniversary

Sixty years ago, the Australian chemist Francis P. Dwyer pioneered the use of ruthenium polypyridyl complexes as biologically active compounds. These chemically inert and configurationally stable complexes revealed an astonishing range of interesting biological activities, such as the inhibition of the enzyme acetylcholinesterase, anti-cancer activity in vivo, and bacteriostatic/bacteriocidal action. This review commemorates the sixtieth anniversary of Dwyer and co-workers’ landmark 1952 publication, summarises their broader achievements in biological inorganic chemistry, and discusses the contribution of this work to the development of modern biological and medicinal inorganic chemistry.

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