scholarly journals Structure-based design, synthesis by click chemistry and in vivo activity of highly selective A3 adenosine receptor agonists

MedChemComm ◽  
2015 ◽  
Vol 6 (4) ◽  
pp. 555-563 ◽  
Author(s):  
Dilip K. Tosh ◽  
Silvia Paoletta ◽  
Zhoumou Chen ◽  
Steven Crane ◽  
John Lloyd ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Adenosine Receptor ◽  
Design Synthesis ◽  
Adenosine Receptor Agonists ◽  
Receptor Agonists ◽  
A3 Adenosine Receptor ◽  
Dark Green ◽  
Light Green

C2-phenylethynyl (dark green) and C2-phenyl-triazolyl (light green) nucleosides in the A3AR.

Design, synthesis and evaluation of N6-substituted 2-aminoadenosine-5′-N-methylcarboxamides as A3 adenosine receptor agonists

MedChemComm ◽  
2014 ◽  
Vol 5 (2) ◽  
pp. 192-196 ◽  
Author(s):  
Shane M. Devine ◽  
Lauren T. May ◽  
Peter J. Scammells
Keyword(s):  
Adenosine Receptor ◽  
Design Synthesis ◽  
Adenosine Receptor Agonists ◽  
Receptor Agonists ◽  
A3 Adenosine Receptor

A series of N6-substituted 2-aminoadenosine-5′-N-methylcarboxamides were synthesized from the versatile intermediate, O6-(benzotriazol-1-yl)-2-amino-2′,3′-O-isopropylideneinosine-5′-N-methylcarboxamide (1) and evaluated as A3 adenosine receptor agonists.

Structure-Based Design, Synthesis, and In Vivo Antinociceptive Effects of Selective A1 Adenosine Receptor Agonists

2018 ◽  
Vol 61 (1) ◽  
pp. 305-318 ◽  
Author(s):  
Riccardo Petrelli ◽  
Mirko Scortichini ◽  
Carmela Belardo ◽  
Serena Boccella ◽  
Livio Luongo ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
A1 Adenosine Receptor ◽  
Design Synthesis ◽  
Adenosine Receptor Agonists ◽  
Receptor Agonists ◽  
Antinociceptive Effects

scholarly journals Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy

2015 ◽  
Vol 6 (7) ◽  
pp. 804-808 ◽  
Author(s):  
Dilip K. Tosh ◽  
Steven Crane ◽  
Zhoumou Chen ◽  
Silvia Paoletta ◽  
Zhan-Guo Gao ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
In Vivo Efficacy ◽  
Adenosine Receptor Agonists ◽  
Receptor Agonists ◽  
A3 Adenosine Receptor

Novel homologated-apio adenosine derivatives as A3 adenosine receptor agonists: design, synthesis and molecular docking studies

RSC Advances ◽  
2016 ◽  
Vol 6 (14) ◽  
pp. 11233-11239 ◽  
Author(s):  
Amarendra Panda ◽  
Suresh Satpati ◽  
Anshuman Dixit ◽  
Shantanu Pal
Keyword(s):  
Molecular Docking ◽  
Molecular Modelling ◽  
Adenosine Receptor ◽  
Docking Studies ◽  
Design Synthesis ◽  
Adenosine Receptor Agonists ◽  
Molecular Docking Studies ◽  
Receptor Agonists ◽  
A3 Adenosine Receptor ◽  
Adenosine Derivatives

A series of homologated-apio adenosine derivatives including homologated-apio IB-MECA and Cl-IB-MECA have been designed and synthesized successfully. The molecular modelling and docking studies of the compounds have been explored as A3AR agonists.

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