scholarly journals In Vivo Phenotypic Screening for Treating Chronic Neuropathic Pain: Modification of C2-Arylethynyl Group of Conformationally Constrained A3 Adenosine Receptor Agonists

2014 ◽  
Vol 57 (23) ◽  
pp. 9901-9914 ◽  
Author(s):  
Dilip K. Tosh ◽  
Amanda Finley ◽  
Silvia Paoletta ◽  
Steven M. Moss ◽  
Zhan-Guo Gao ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Adenosine Receptor ◽  
Phenotypic Screening ◽  
Chronic Neuropathic Pain ◽  
Adenosine Receptor Agonists ◽  
Conformationally Constrained ◽  
Receptor Agonists ◽  
A3 Adenosine Receptor

scholarly journals Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy

2015 ◽  
Vol 6 (7) ◽  
pp. 804-808 ◽  
Author(s):  
Dilip K. Tosh ◽  
Steven Crane ◽  
Zhoumou Chen ◽  
Silvia Paoletta ◽  
Zhan-Guo Gao ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
In Vivo Efficacy ◽  
Adenosine Receptor Agonists ◽  
Receptor Agonists ◽  
A3 Adenosine Receptor

scholarly journals Structure-based design, synthesis by click chemistry and in vivo activity of highly selective A3 adenosine receptor agonists

MedChemComm ◽  
2015 ◽  
Vol 6 (4) ◽  
pp. 555-563 ◽  
Author(s):  
Dilip K. Tosh ◽  
Silvia Paoletta ◽  
Zhoumou Chen ◽  
Steven Crane ◽  
John Lloyd ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Adenosine Receptor ◽  
Design Synthesis ◽  
Adenosine Receptor Agonists ◽  
Receptor Agonists ◽  
A3 Adenosine Receptor ◽  
Dark Green ◽  
Light Green

C2-phenylethynyl (dark green) and C2-phenyl-triazolyl (light green) nucleosides in the A3AR.

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