scholarly journals Membrane-interacting properties of the functionalised fatty acid moiety of muraymycin antibiotics

MedChemComm ◽  
2015 ◽  
Vol 6 (5) ◽  
pp. 879-886 ◽  
Author(s):  
Oliver Ries ◽  
Christian Carnarius ◽  
Claudia Steinem ◽  
Christian Ducho

A simplified model system is introduced to elucidate the significance of the ω-functionalised fatty acid moiety of muraymycin nucleoside antibiotics for membrane interaction and penetration.

Nature ◽  
1991 ◽  
Vol 354 (6349) ◽  
pp. 125-130 ◽  
Author(s):  
Herman P. Spaink ◽  
Douglas M. Sheeley ◽  
Anton A. N. van Brussel ◽  
John Glushka ◽  
William S. York ◽  
...  

1981 ◽  
Vol 194 (3) ◽  
pp. 783-787 ◽  
Author(s):  
B D Nelson ◽  
S Fleischer

Phospholipid requirements for the reconstitution of Complex-III vesicles exhibiting respiratory control (electron-transport control) were studied. Vesicles prepared from pure phosphatidylethanolamine gave maximal control ratios. Phosphatidylcholine alone did not support respiratory control, although these vesicles were capable of maintaining stable K+-diffusion gradients. Apparently Complex III cannot insert into a bilayer of phosphatidylcholine. Formation of mixed phosphatidylcholine/phosphatidylethanolamine (6:1, w/w) vesicles was sufficient, however, to allow Complex-III insertion and to restore respiratory control. Mixtures of acidic phospholipids with either phosphatidylethanolamine or phosphatidylcholine did not improve respiratory control over that obtained with pure phosphatidylethanolamine. Phosphatidylethanolamine from bovine heart mitochondria, soya beans or Escherichia coli was equally effective in reconstituting respiratory control, suggesting that the specificity is referable to the head group and not to the fatty-acid moiety.


2003 ◽  
Vol 278 (15) ◽  
pp. 12946-12954 ◽  
Author(s):  
Larissa A. Sharypova ◽  
Karsten Niehaus ◽  
Heiko Scheidle ◽  
Otto Holst ◽  
Anke Becker

Neonatology ◽  
1974 ◽  
Vol 24 (5-6) ◽  
pp. 292-297 ◽  
Author(s):  
L. Hummel ◽  
W. Schirrmeister ◽  
T. Zimmermann

ChemInform ◽  
2010 ◽  
Vol 23 (48) ◽  
pp. no-no
Author(s):  
R. VERDUYN ◽  
R. M. LAGAS ◽  
C. E. DREEF ◽  
G. A. VAN DER MAREL ◽  
J. H. VAN BOOM

1959 ◽  
Vol 37 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Doris Howes Calloway ◽  
George W. Kurtz ◽  
Rorert B. Potts

Palmitic, oleic, and butyric acid esters of cetyl alcohol were fed to mature rats. Cetyl palmitate was quantitatively excreted in the feces and produced no physiologic aberration. While cetyl oleate was 75% absorbable, it was of little value as an energy source and was partially excreted through the skin. Feeding of cetyl butyrate also induced seborrhea. Data on free fatty acids in gastrointestinal contents and on the specificity of seborrheic lipids indicate that cetyl esters are largely absorbed without hydrolysis, if the fatty acid moiety is readily absorbable, and excreted by way of the skin without modification.


2009 ◽  
Vol 42 (7) ◽  
pp. 599-605 ◽  
Author(s):  
F.C.C. Grando ◽  
C.A. Felício ◽  
A. Twardowschy ◽  
F.M. Paula ◽  
V.G. Batista ◽  
...  

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