Exploring the prominent performance of CX-4945 derivatives as protein kinase CK2 inhibitors by a combined computational study

2014 ◽  
Vol 10 (5) ◽  
pp. 1196-1210 ◽  
Author(s):  
Xuwen Wang ◽  
Peichen Pan ◽  
Youyong Li ◽  
Dan Li ◽  
Tingjun Hou
Keyword(s):  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Computational Study ◽  
Casein Kinase Ii ◽  
Casein Kinase ◽  
Potential Target ◽  
Cellular Events ◽  
P Protein ◽  
Kinase Ck2 ◽  
Ck2 Inhibitors

Protein kinase CK2, also known as casein kinase II, is related to various cellular events and is a potential target for numerous cancers.

scholarly journals Structural Determinants of CX-4945 Derivatives as Protein Kinase CK2 Inhibitors: A Computational Study

2011 ◽  
Vol 12 (10) ◽  
pp. 7004-7021 ◽  
Author(s):  
Hongbo Liu ◽  
Xia Wang ◽  
Jian Wang ◽  
Jinghui Wang ◽  
Yan Li ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Computational Study ◽  
Structural Determinants ◽  
Kinase Ck2 ◽  
Ck2 Inhibitors

Structural insights into flavones as protein kinase CK2 inhibitors derived from a combined computational study

RSC Advances ◽  
2015 ◽  
Vol 5 (1) ◽  
pp. 462-476 ◽  
Author(s):  
Min Lv ◽  
Shuying Ma ◽  
Yueli Tian ◽  
Xiaoyun Zhang ◽  
Honglin Zhai ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Computational Study ◽  
Binding Conformation ◽  
Kinase Ck2 ◽  
Ck2 Inhibitors ◽  
Structural Insights

Binding conformation of flavone inhibitors to protein kinase CK2.

Discovery of new protein kinase CK2 inhibitors with 1,3-dioxo-2,3-dihydro-1H-indene core

MedChemComm ◽  
2016 ◽  
Vol 7 (7) ◽  
pp. 1352-1355 ◽  
Author(s):  
Zong-liang Liu ◽  
Ren-mei Zhang ◽  
Qing-guo Meng ◽  
Xiao-chen Zhang ◽  
Yuan Sun
Keyword(s):  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
P Protein ◽  
Anticancer Target ◽  
Kinase Ck2 ◽  
Ck2 Inhibitors ◽  
New Protein

Protein kinase CK2 (CK2) serves as an attractive anticancer target. Herein new CK2 inhibitors with a 1,3-dioxo-2,3-dihydro-1H-indene core are reported.

Analysis of interactions between the subunits of protein kinase CK2

1996 ◽  
Vol 74 (4) ◽  
pp. 541-547 ◽  
Author(s):  
David W. Litchfield ◽  
Elzbieta Slominski ◽  
Shawn Lewenza ◽  
Michael Narvey ◽  
Denis G. Bosc ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Hybrid System ◽  
Protein Kinase Ck2 ◽  
Casein Kinase Ii ◽  
Casein Kinase ◽  
Yeast Two Hybrid ◽  
Yeast Two Hybrid System ◽  
Kinase Ck2 ◽  
Α Subunits ◽  
Two Hybrid

Protein kinase CK2, which was formerly known as casein kinase II, is a highly conserved protein serine/threonine kinase implicated in the control of cell proliferation through its phosphorylation of regulatory nuclear proteins. The enzyme consists of catalytic (α and (or) α′) subunits and β subunits that modulate the activity of the catalytic subunits. These subunits are arranged in homotetrameric (i.e., α2β2 or α′2β2) or heterotetrameric (i.e., αα′β2) complexes. We previously demonstrated using the yeast two-hybrid system that α (or α′) subunits can interact with β subunits but not other α (or α′) subunits. By comparison, β subunits can interact with α (or α′) and with β subunits, suggesting that the protein kinase CK2 holoenzyme forms because of the ability of p subunits to dimerize, bringing two heterodimers (αβ or α′β) into a tetrameric complex. In the present study, we used the yeast two-hybrid system to examine the domains of interactions between the α and β subunits of protein kinase CK2. These studies indicate that the ability of β to interact with α resides within the carboxy-terminal domain of β. By comparison, our studies suggest that individual domains of α are not sufficient for interactions with β.Key words: protein kinase CK2, casein kinase II, yeast two-hybrid system, subunit interaction, signal transduction.

scholarly journals Impact of protein kinase CK2 inhibitors on proliferation and differentiation of neural stem cells

Heliyon ◽  
2017 ◽  
Vol 3 (6) ◽  
pp. e00318 ◽  
Author(s):  
Melanie Bender ◽  
Lisa Schwind ◽  
David Grundmann ◽  
Monika Martin ◽  
Markus Klotz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Protein Kinase ◽  
Neural Stem Cells ◽  
Protein Kinase Ck2 ◽  
Proliferation And Differentiation ◽  
Kinase Ck2 ◽  
Ck2 Inhibitors

Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors

2012 ◽  
Vol 20 (7) ◽  
pp. 2282-2289 ◽  
Author(s):  
Claas Hundsdörfer ◽  
Hans-Jörg Hemmerling ◽  
Claudia Götz ◽  
Frank Totzke ◽  
Patrick Bednarski ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Human Protein ◽  
Indole Derivatives ◽  
Human Protein Kinase ◽  
Kinase Ck2 ◽  
Ck2 Inhibitors

Tetrabromocinnamic Acid (TBCA) and Related Compounds Represent a New Class of Specific Protein Kinase CK2 Inhibitors

ChemBioChem ◽  
2007 ◽  
Vol 8 (1) ◽  
pp. 129-139 ◽  
Author(s):  
Mario A. Pagano ◽  
Giorgia Poletto ◽  
Giovanni Di Maira ◽  
Giorgio Cozza ◽  
Maria Ruzzene ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Specific Protein ◽  
New Class ◽  
Kinase Ck2 ◽  
Related Compounds ◽  
Ck2 Inhibitors ◽  
Specific Protein Kinase
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