Continuous flow generation of magnetoliposomes in a low-cost portable microfluidic platform

Lab on a Chip ◽  
2014 ◽  
Vol 14 (23) ◽  
pp. 4506-4512 ◽  
Author(s):  
Alvaro J. Conde ◽  
Milena Batalla ◽  
Belén Cerda ◽  
Olga Mykhaylyk ◽  
Christian Plank ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Low Cost ◽  
Microfluidic Platform ◽  
Flow Generation

A low-cost, portable microfluidic platform for preparing monodisperse magnetoliposomal suspensions that does not require extrusion steps.

scholarly journals Continuous dimethyldioxirane generation for polymer epoxidation

2021 ◽  
Vol 12 (4) ◽  
pp. 489-493
Author(s):  
Grace P. Ahlqvist ◽  
Eileen G. Burke ◽  
Jeremiah A. Johnson ◽  
Timothy F. Jamison
Keyword(s):  
Continuous Flow ◽  
Low Level ◽  
Flow Generation

Herein we describe the development of a reactor for the continuous flow generation and use of dimethyldioxirane (DMDO) and its application to the low-level epoxidation of unsaturated polymers.

A Sequential Ugi Multicomponent/Cu-Catalyzed Azide–Alkyne Cycloaddition Approach for the Continuous Flow Generation of Cyclic Peptoids

2015 ◽  
Vol 80 (9) ◽  
pp. 4590-4602 ◽  
Author(s):  
Carlos Eduardo M. Salvador ◽  
Bartholomäus Pieber ◽  
Philipp M. Neu ◽  
Ana Torvisco ◽  
Carlos Kleber Z. Andrade ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Generation

Continuous flow biodiesel production from wet microalgae using a hybrid thin film microfluidic platform

2018 ◽  
Vol 54 (85) ◽  
pp. 12085-12088 ◽  
Author(s):  
Eko K. Sitepu ◽  
Darryl B. Jones ◽  
Youhong Tang ◽  
Sophie C. Leterme ◽  
Kirsten Heimann ◽  
...  
Keyword(s):  
Thin Film ◽  
Continuous Flow ◽  
Room Temperature ◽  
Biodiesel Production ◽  
High Yield ◽  
Hybrid Thin Film ◽  
Microfluidic Platform ◽  
Thin Film Device ◽  
Wet Microalgae

A novel continuous flow turbo-thin film device (T2FD) is effective in producing biodiesel in high yield from wet microalgae at room temperature.

Dielectrophoresis-based microfluidic platform to sort micro-particles in continuous flow

2019 ◽  
Vol 26 (3) ◽  
pp. 751-763
Author(s):  
Mohsen Hajari ◽  
Amirali Ebadi ◽  
Mohammad Javad Farshchi Heydari ◽  
Morteza Fathipour ◽  
Madjid Soltani
Keyword(s):  
Continuous Flow ◽  
Microfluidic Platform ◽  
Micro Particles

Integrated Synthesis Using Isothiocyanate-Substituted Aryllithiums by Flow Chemistry

Synlett ◽  
2020 ◽  
Vol 31 (19) ◽  
pp. 1899-1902
Author(s):  
Jun-ichi Yoshida ◽  
Heejin Kim ◽  
Hyune-Jea Lee ◽  
Daiki Torii ◽  
Yongju Jeon
Keyword(s):  
Biological Activity ◽  
Exchange Reaction ◽  
Continuous Flow ◽  
Functional Group ◽  
Flow Chemistry ◽  
Fluorescent Labeling ◽  
Pharmaceutical Chemistry ◽  
Flow Reactors ◽  
Flow Generation ◽  
Continuous Flow Reactors

The isothiocyanate (NCS) group is an attractive functional group in the field of organic and pharmaceutical chemistry. It can be transformed into other heteroatomic functional groups. It usually acts as the inductive group of biological activity and has also been traditionally used as the fluorescent-labeling reagent. However, it is not compatible with strong bases. When the NCS group is at para position in halobenzenes, it generally undergoes nucleophilic additions upon reaction with strong bases. To the best of our knowledge, there is currently no general methodology for the formation and reactions of NCS-functionalized aryllithiums for meta and para substituents. Herein, we report the continuous-flow generation of NCS-substituted aryllithiums from the corresponding haloarenes via a selective halogen–lithium exchange reaction and its reaction with various electrophiles to yield NCS-containing products. We also achieved an integrated synthesis through sequential reactions of the NCS-containing compounds with additional nucleophiles using the continuous-flow reactors.

Single- and coupled-enzyme nylon-tube reactors for plasma glucose determination with glucose oxidase and aldehyde dehydrogenase.

1980 ◽  
Vol 26 (12) ◽  
pp. 1652-1655 ◽  
Author(s):  
W Hinsch ◽  
A Antonijewić ◽  
P V Sundaram
Keyword(s):  
Glucose Oxidase ◽  
Aldehyde Dehydrogenase ◽  
Plasma Glucose ◽  
Continuous Flow ◽  
Flow System ◽  
Low Cost ◽  
Immobilized Enzymes ◽  
Glucose Determination ◽  
Nylon Tube

Abstract We describe routine methods for determining glucose in plasma with use of aldehyde dehydrogenase or glucose oxidase-aldehyde dehydrogenase immobilized in a nylon tube that is integrated into a continuous-flow system. Although the coupled-enzyme nylon-tube reactors require the presence of a third enzyme, catalase, in solution, the kinetics are not so complicated as to preclude reliable routine determination of glucose at very low cost. Precision is good, and results correlate well with those by the method involving glucose oxidase in solution. More than 3000 tests may be carried out with one reactor. The immobilized enzymes are stable for several months at 4 degrees C when not in use.

Experimental investigation of a low cost inclined wick solar still with forced continuous flow

2021 ◽  
Author(s):  
Mohamed M.Z. Ahmed ◽  
Fuhaid Alshammari ◽  
A.S. Abdullah ◽  
Mohamed Elashmawy
Keyword(s):  
Experimental Investigation ◽  
Continuous Flow ◽  
Low Cost ◽  
Solar Still

scholarly journals A microfluidic platform for highly parallel bite by bite profiling of mosquito-borne pathogen transmission

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Shailabh Kumar ◽  
Felix J. H. Hol ◽  
Sujit Pujhari ◽  
Clayton Ellington ◽  
Haripriya Vaidehi Narayanan ◽  
...  
Keyword(s):  
Low Cost ◽  
Blood Feeding ◽  
Pathogen Transmission ◽  
Membrane Thickness ◽  
Sample Collection ◽  
Microfluidic Platform ◽  
Virus Particles ◽  
Virus Rna ◽  
On Chip ◽  
Mayaro Virus

AbstractMosquito bites transmit a number of pathogens via salivary droplets deposited during blood-feeding, resulting in potentially fatal diseases. Little is known about the genomic content of these nanodroplets, including the transmission dynamics of live pathogens. Here we introduce Vectorchip, a low-cost, scalable microfluidic platform enabling high-throughput molecular interrogation of individual mosquito bites. We introduce an ultra-thin PDMS membrane which acts as a biting interface to arrays of micro-wells. Freely-behaving mosquitoes deposit saliva droplets by biting into these micro-wells. By modulating membrane thickness, we observe species-dependent differences in mosquito biting capacity, utilizable for selective sample collection. We demonstrate RT-PCR and focus-forming assays on-chip to detect mosquito DNA, Zika virus RNA, as well as quantify infectious Mayaro virus particles transmitted from single mosquito bites. The Vectorchip presents a promising approach for single-bite-resolution laboratory and field characterization of vector-pathogen communities, and could serve as a powerful early warning sentinel for mosquito-borne diseases.

scholarly journals Continuous- versus Segmented-Flow Microfluidic Synthesis in Materials Science

Crystals ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 12 ◽  
Author(s):  
Mathieu Gonidec ◽  
Josep Puigmartí-Luis
Keyword(s):  
Continuous Flow ◽  
Materials Science ◽  
Low Cost ◽  
Parallel Evolution ◽  
Reaction Diffusion ◽  
Functional Materials ◽  
Microfluidic Devices ◽  
Research Field ◽  
Segmented Flow ◽  
Materials Synthesis

Materials science is a fast-evolving area that aims to uncover functional materials with ever more sophisticated properties and functions. For this to happen, new methodologies for materials synthesis, optimization, and preparation are desired. In this context, microfluidic technologies have emerged as a key enabling tool for a low-cost and fast prototyping of materials. Their ability to screen multiple reaction conditions rapidly with a small amount of reagent, together with their unique physico-chemical characteristics, have made microfluidic devices a cornerstone technology in this research field. Among the different microfluidic approaches to materials synthesis, the main contenders can be classified in two categories: continuous-flow and segmented-flow microfluidic devices. These two families of devices present very distinct characteristics, but they are often pooled together in general discussions about the field with seemingly little awareness of the major divide between them. In this perspective, we outline the parallel evolution of those two sub-fields by highlighting the key differences between both approaches, via a discussion of their main achievements. We show how continuous-flow microfluidic approaches, mimicking nature, provide very finely-tuned chemical gradients that yield highly-controlled reaction–diffusion (RD) areas, while segmented-flow microfluidic systems provide, on the contrary, very fast homogenization methods, and therefore well-defined super-saturation regimes inside arrays of micro-droplets that can be manipulated and controlled at the milliseconds scale. Those two classes of microfluidic reactors thus provide unique and complementary advantages over classical batch synthesis, with a drive towards the rational synthesis of out-of-equilibrium states for the former, and the preparation of high-quality and complex nanoparticles with narrow size distributions for the latter.

Sign in / Sign up

Export Citation Format

Share Document