A Sequential Ugi Multicomponent/Cu-Catalyzed Azide–Alkyne Cycloaddition Approach for the Continuous Flow Generation of Cyclic Peptoids

2015 ◽  
Vol 80 (9) ◽  
pp. 4590-4602 ◽  
Author(s):  
Carlos Eduardo M. Salvador ◽  
Bartholomäus Pieber ◽  
Philipp M. Neu ◽  
Ana Torvisco ◽  
Carlos Kleber Z. Andrade ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Generation

scholarly journals Continuous dimethyldioxirane generation for polymer epoxidation

2021 ◽  
Vol 12 (4) ◽  
pp. 489-493
Author(s):  
Grace P. Ahlqvist ◽  
Eileen G. Burke ◽  
Jeremiah A. Johnson ◽  
Timothy F. Jamison
Keyword(s):  
Continuous Flow ◽  
Low Level ◽  
Flow Generation

Herein we describe the development of a reactor for the continuous flow generation and use of dimethyldioxirane (DMDO) and its application to the low-level epoxidation of unsaturated polymers.

Integrated Synthesis Using Isothiocyanate-Substituted Aryllithiums by Flow Chemistry

Synlett ◽  
2020 ◽  
Vol 31 (19) ◽  
pp. 1899-1902
Author(s):  
Jun-ichi Yoshida ◽  
Heejin Kim ◽  
Hyune-Jea Lee ◽  
Daiki Torii ◽  
Yongju Jeon
Keyword(s):  
Biological Activity ◽  
Exchange Reaction ◽  
Continuous Flow ◽  
Functional Group ◽  
Flow Chemistry ◽  
Fluorescent Labeling ◽  
Pharmaceutical Chemistry ◽  
Flow Reactors ◽  
Flow Generation ◽  
Continuous Flow Reactors

The isothiocyanate (NCS) group is an attractive functional group in the field of organic and pharmaceutical chemistry. It can be transformed into other heteroatomic functional groups. It usually acts as the inductive group of biological activity and has also been traditionally used as the fluorescent-labeling reagent. However, it is not compatible with strong bases. When the NCS group is at para position in halobenzenes, it generally undergoes nucleophilic additions upon reaction with strong bases. To the best of our knowledge, there is currently no general methodology for the formation and reactions of NCS-functionalized aryllithiums for meta and para substituents. Herein, we report the continuous-flow generation of NCS-substituted aryllithiums from the corresponding haloarenes via a selective halogen–lithium exchange reaction and its reaction with various electrophiles to yield NCS-containing products. We also achieved an integrated synthesis through sequential reactions of the NCS-containing compounds with additional nucleophiles using the continuous-flow reactors.

Continuous Flow Generation and Reactions of Anhydrous Diazomethane Using a Teflon AF-2400 Tube-in-Tube Reactor

2013 ◽  
Vol 15 (21) ◽  
pp. 5590-5593 ◽  
Author(s):  
Federica Mastronardi ◽  
Bernhard Gutmann ◽  
C. Oliver Kappe
Keyword(s):  
Continuous Flow ◽  
Teflon Af ◽  
Tube Reactor ◽  
Flow Generation

Continuous-flow generation of diazoesters and their direct use in S–H and P–H insertion reactions: synthesis of α-sulfanyl, α-sulfonyl, and α-phosphono carboxylates

Tetrahedron ◽  
2013 ◽  
Vol 69 (10) ◽  
pp. 2276-2282 ◽  
Author(s):  
Hannah E. Bartrum ◽  
David C. Blakemore ◽  
Christopher J. Moody ◽  
Christopher J. Hayes
Keyword(s):  
Continuous Flow ◽  
Insertion Reactions ◽  
Flow Generation ◽  
Direct Use

scholarly journals Organomagnesium Based Flash Chemistry: Continuous Flow Generation and Utilization of Halomethylmagnesium Intermediates

2020 ◽  
Vol 22 (19) ◽  
pp. 7537-7541
Author(s):  
Timo von Keutz ◽  
David Cantillo ◽  
C. Oliver Kappe
Keyword(s):  
Continuous Flow ◽  
Flow Generation

Rapid Access to α-Alkoxy and α-Amino Acid Derivatives through Safe Continuous-Flow Generation of Diazoesters

2011 ◽  
Vol 17 (35) ◽  
pp. 9586-9589 ◽  
Author(s):  
Hannah E. Bartrum ◽  
David C. Blakemore ◽  
Christopher J. Moody ◽  
Christopher J. Hayes
Keyword(s):  
Amino Acid ◽  
Continuous Flow ◽  
Amino Acid Derivatives ◽  
Rapid Access ◽  
Flow Generation

Telescoped continuous flow generation of a library of highly substituted 3-thio-1,2,4-triazoles

2017 ◽  
Vol 2 (6) ◽  
pp. 896-907 ◽  
Author(s):  
Mariana C. F. C. B. Damião ◽  
Renan Galaverna ◽  
Alan P. Kozikowski ◽  
James Eubanks ◽  
Julio C. Pastre
Keyword(s):  
Residence Time ◽  
Continuous Flow ◽  
Flow Process ◽  
Flow Generation ◽  
Continuous Flow Process

An integrated continuous flow process for the synthesis of 3-thio-1,2,4-triazoles is reported. A small library of 18 compounds was prepared in just 48 minutes of residence time in moderate to excellent yields.

scholarly journals Dual roles of cellulose monolith in the continuous-flow generation and support of gold nanoparticles for green catalyst

2020 ◽  
Vol 247 ◽  
pp. 116723 ◽  
Author(s):  
Zheng-Tian Xie ◽  
Taka-Aki Asoh ◽  
Yuta Uetake ◽  
Hidehiro Sakurai ◽  
Hiroshi Uyama
Keyword(s):  
Gold Nanoparticles ◽  
Continuous Flow ◽  
Dual Roles ◽  
Green Catalyst ◽  
Flow Generation

Continuous flow generation of magnetoliposomes in a low-cost portable microfluidic platform

Lab on a Chip ◽  
2014 ◽  
Vol 14 (23) ◽  
pp. 4506-4512 ◽  
Author(s):  
Alvaro J. Conde ◽  
Milena Batalla ◽  
Belén Cerda ◽  
Olga Mykhaylyk ◽  
Christian Plank ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Low Cost ◽  
Microfluidic Platform ◽  
Flow Generation

A low-cost, portable microfluidic platform for preparing monodisperse magnetoliposomal suspensions that does not require extrusion steps.

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