An optoelectrokinetic technique for programmable particle manipulation and bead-based biosignal enhancement

Lab on a Chip ◽  
2014 ◽  
Vol 14 (20) ◽  
pp. 3958-3967 ◽  
Author(s):  
Kuan-Chih Wang ◽  
Aloke Kumar ◽  
Stuart J. Williams ◽  
Nicolas G. Green ◽  
Kyung Chun Kim ◽  
...  
Keyword(s):  
Particle Manipulation ◽  
Rapid Electrokinetic Patterning

An optoelectrokinetic technique, termed Rapid Electrokinetic Patterning (REP), was used to enhance the signal in bead-based bioassays. REP can achieve various manipulation capabilities.

Optically Induced Electrokinetic Trapping and Sorting of Colloids

2010 ◽  
Author(s):  
Stuart J. Williams ◽  
Aloke Kumar ◽  
Steven T. Wereley
Keyword(s):  
Electrical Conductivity ◽  
Surface Modification ◽  
Particle Diameter ◽  
Lab On A Chip ◽  
Particle Manipulation ◽  
Complete Understanding ◽  
Heating Source ◽  
Electrokinetic Trapping ◽  
Rapid Electrokinetic Patterning ◽  
Optically Induced

Recently, we have demonstrated electrothermal hydrodynamics with an external heating source of a highly focused 1,064 nm laser beam [1]. This phenomenon, when coupled with particle-electrode electrokinetic interactions, has led to the rapid and selective concentration of suspended colloids [2–6]. This technique, termed Rapid Electrokinetic Patterning (REP) was demonstrated without any additional surface modification or patterning of the electrodes. This dynamic, optically induced fluid and particle manipulation technique could be used for a variety of lab-on-a-chip applications. However, there are additional effects that have yet to be investigated that are important for a complete understanding of REP. This paper showcases experimental particle-particle behavior observations by varying particle diameter, electrode material, and preliminary results of varying fluid electrical conductivity.

Development of a Bead-Based Optoelectrokinetic Immunosensing Technique for Detection of Low-Abundance Analytes

2017 ◽  
Author(s):  
Han-Sheng Chuang ◽  
Hsiao-Neng Lin ◽  
Hu-Yao Ku
Keyword(s):  
Limit Of Detection ◽  
Point Of Care ◽  
Particle Manipulation ◽  
Great Flexibility ◽  
Point Of Care Diagnostics ◽  
Combined Use ◽  
Tnf Α ◽  
Rapid Electrokinetic Patterning ◽  
Sample Droplet ◽  
Made In

Bead-based immunosensing has been growing as a promising technology in the point-of-care diagnostics because of great flexibility. For dilute samples, functionalized particles can be used to collect dispersed analytes and act as carriers for particle manipulation. To carry out rapid and selective diagnosis, a bead-based optoelectrokinetic immunosensing technique was developed herein to detect biomarkers, lipocalin 1 (LCN1) and TNF-α, for diabetic retinopathy (DR). The measurement was made in a sample droplet sandwiched between two parallel electrodes. With an electric field and a focused laser beam simultaneously applying on the microchip, the immunocomplexes in the droplet were further concentrated within the region of irradiation to enhance the fluorescent signal. The optoelectrokinetic platform, termed rapid electrokinetic patterning (REP), is excellent in dynamic and programmable particle manipulation. Therefore, the detection could be complete in roughly 10 s. With an appropriate frequency modulation, the two DR biomarkers were detected at a time. The limit of detection (LOD) of the REP-enabled measurement reached as low as 100 pg/mL. The combined use of bead-based immunoassays and the optoelectrokinetic platform therefore provides an insightful measure to the early diagnosis of diseases.

scholarly journals Antiresonant driven systems for particle manipulation

2021 ◽  
Vol 103 (6) ◽  
Author(s):  
M. Florencia Carusela ◽  
Paolo Malgaretti ◽  
J. Miguel Rubi
Keyword(s):  
Particle Manipulation ◽  
Driven Systems

scholarly journals Optical vortex lattice: an exploitation of orbital angular momentum

Nanophotonics ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Liuhao Zhu ◽  
Miaomiao Tang ◽  
Hehe Li ◽  
Yuping Tai ◽  
Xinzhong Li
Keyword(s):  
Angular Momentum ◽  
Optical Tweezers ◽  
Orbital Angular Momentum ◽  
Vortex Lattice ◽  
Optical Vortex ◽  
Yeast Cells ◽  
Particle Manipulation ◽  
Complex Motion ◽  
Potential Applications ◽  
Vortex Beams

Abstract Generally, an optical vortex lattice (OVL) is generated via the superposition of two specific vortex beams. Thus far, OVL has been successfully employed to trap atoms via the dark cores. The topological charge (TC) on each optical vortex (OV) in the lattice is only ±1. Consequently, the orbital angular momentum (OAM) on the lattice is ignored. To expand the potential applications, it is necessary to rediscover and exploit OAM. Here we propose a novel high-order OVL (HO-OVL) that combines the phase multiplication and the arbitrary mode-controllable techniques. TC on each OV in the lattice is up to 51, which generates sufficient OAM to manipulate microparticles. Thereafter, the entire lattice can be modulated to desirable arbitrary modes. Finally, yeast cells are trapped and rotated by the proposed HO-OVL. To the best of our knowledge, this is the first realization of the complex motion of microparticles via OVL. Thus, this work successfully exploits OAM on OVL, thereby revealing potential applications in particle manipulation and optical tweezers.

Towards New Methodologies for Manipulation of Colloidal Particles in a Miniaturized Fluidic Device: Optoelectrokinetic Manipulation Technique

2013 ◽  
Vol 135 (2) ◽  
Author(s):  
Jae-Sung Kwon ◽  
Steven T. Wereley
Keyword(s):  
Microfluidic Chip ◽  
Colloidal Particles ◽  
Future Prospects ◽  
Simultaneous Application ◽  
Laser Illumination ◽  
Research Fields ◽  
Ac Electric Field ◽  
Fluidic Device ◽  
New Methodologies ◽  
Rapid Electrokinetic Patterning

The rapid electrokinetic patterning (REP) technique developed recently is a hybrid optoelectrokinetic one that manipulates micro- or nanocolloids in a microfluidic chip using the simultaneous application of a uniform ac electric field and laser illumination. Since its invention, the technique has been applied to many research fields with promising potential, but these applications are still in their early stages. In order to effectively complete and leverage the applications, this paper reviews the publications concerning the REP technique and discusses its underlying principles, applications, and future prospects.

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