scholarly journals Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases

2014 ◽  
Vol 6 (5) ◽  
pp. 486-510 ◽  
Author(s):  
Etheresia Pretorius ◽  
Douglas B. Kell
Keyword(s):  
Inflammatory Diseases ◽  
Communicable Diseases ◽  
Non Communicable Diseases ◽  
Considerable Evidence ◽  
Biophysical Indicators ◽  
Inflammatory Changes

Most non-communicable diseases involve inflammatory changes in one or more vascular systems, and there is considerable evidence that unliganded iron plays major roles in this.

scholarly journals The mercapturomic profile of health and non-communicable diseases

2019 ◽  
Vol 8 (2) ◽  
pp. 10 ◽  
Author(s):  
Gonçalves-Dias ◽  
Morello ◽  
Semedo ◽  
Correia ◽  
Coelho ◽  
...  
Keyword(s):  
Environmental Exposure ◽  
Inflammatory Diseases ◽  
Communicable Diseases ◽  
Non Communicable Diseases ◽  
Chronic Inflammatory Diseases ◽  
Cardiometabolic Diseases ◽  
Health And Disease ◽  
Endogenous Metabolites

The mercapturate pathway is a unique metabolic circuitry that detoxifies electrophiles upon adducts formation with glutathione. Since its discovery over a century ago, most of the knowledge on the mercapturate pathway has been provided from biomonitoring studies on environmental exposure to toxicants. However, the mercapturate pathway-related metabolites that is formed in humans—the mercapturomic profile—in health and disease is yet to be established. In this paper, we put forward the hypothesis that these metabolites are key pathophysiologic factors behind the onset and development of non-communicable chronic inflammatory diseases. This review goes from the evidence in the formation of endogenous metabolites undergoing the mercapturate pathway to the methodologies for their assessment and their association with cancer and respiratory, neurologic and cardiometabolic diseases.

scholarly journals Vascular Endothelial Growth Factor: A Translational View in Oral Non-Communicable Diseases

Biomolecules ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 85
Author(s):  
Sven Niklander ◽  
María José Bordagaray ◽  
Alejandra Fernández ◽  
Marcela Hernández
Keyword(s):  
Growth Factors ◽  
Oral Cancer ◽  
Inflammatory Diseases ◽  
Communicable Diseases ◽  
Vascular Endothelial ◽  
Bone Homeostasis ◽  
Non Communicable Diseases ◽  
Vegf Signaling ◽  
Periodontal Tissues

Vascular endothelial growth factors (VEGFs) are vital regulators of angiogenesis that are expressed in response to soluble mediators, such as cytokines and growth factors. Their physiologic functions include blood vessel formation, regulation of vascular permeability, stem cell and monocyte/macrophage recruitment and maintenance of bone homeostasis and repair. In addition, angiogenesis plays a pivotal role in chronic pathologic conditions, such as tumorigenesis, inflammatory immune diseases and bone loss. According to their prevalence, morbidity and mortality, inflammatory diseases affecting periodontal tissues and oral cancer are relevant non-communicable diseases. Whereas oral squamous cell carcinoma (OSCC) is considered one of the most common cancers worldwide, destructive inflammatory periodontal diseases, on the other hand, are amongst the most prevalent chronic inflammatory conditions affecting humans and also represent the main cause of tooth loss in adults. In the recent years, while knowledge regarding the role of VEGF signaling in common oral diseases is expanding, new potential translational applications emerge. In the present narrative review we aim to explore the role of VEGF signaling in oral cancer and destructive periodontal inflammatory diseases, with emphasis in its translational applications as potential biomarkers and therapeutic targets.

scholarly journals Combination therapy of oropharyngeal inflammatory diseases in children

2016 ◽  
Vol 1 (1) ◽  
pp. 54-57 ◽  
Author(s):  
D. V. Usenko ◽  
A. V. Gorelov
Keyword(s):  
Combination Therapy ◽  
Infectious Diseases ◽  
Lymphoid Tissue ◽  
Inflammatory Diseases ◽  
Communicable Diseases ◽  
Clinical Findings ◽  
Non Communicable Diseases

Inflammatory oropharyngeal pathologies are diverse in etiology and include infectious diseases, lesions of the lymphoid tissue of the pharynx, as well as non-communicable diseases. The article summarizes the results of studies and clinical findings on the effectiveness Lysobact in the treatment of inflammatory diseases of the oropharynx in children.

scholarly journals Gut Microbiota during Dietary Restrictions: New Insights in Non-Communicable Diseases

2020 ◽  
Vol 8 (8) ◽  
pp. 1140 ◽  
Author(s):  
Emanuele Rinninella ◽  
Marco Cintoni ◽  
Pauline Raoul ◽  
Gianluca Ianiro ◽  
Lucrezia Laterza ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Inflammatory Diseases ◽  
Communicable Diseases ◽  
Gut Barrier ◽  
Health Span ◽  
Non Communicable Diseases ◽  
Beneficial Effects ◽  
Brain Functions ◽  
Dietary Restrictions ◽  
Age Related

In recent decades, there has been a growing interest in dietary restrictions for their promising effects on longevity and health span. Indeed, these strategies are supposed to delay the onset and burden of non-communicable diseases (NCDs) such as obesity, diabetes, cancer and neurological and gastrointestinal inflammatory diseases. At the same time, the gut microbiota has been shown to play a crucial role in NCDs since it is actively involved in maintaining gut homeostasis through its impact on nutrients metabolism, gut barrier, and immune system. There is evidence that dietary restrictions could slow down age-related changes in the types and numbers of gut bacteria, which may counteract gut dysbiosis. The beneficial effects on gut microbiota may positively influence host metabolism, gut barrier permeability, and brain functions, and subsequently, postpone the onset of NCDs prolonging the health span. These new insights could lead to the development of novel strategies for modulating gut microbiota with the end goal of treating/preventing NCDs. This review provides an overview of animal and human studies focusing on gut microbiota variations during different types of dietary restriction, in order to highlight the close relationship between gut microbiota balance and the host’s health benefits induced by these nutritional regimens.

Adipositasprävention und non-communicable diseases

2012 ◽  
Vol 06 (04) ◽  
pp. 249-251
Author(s):  
M. Braun ◽  
J. Ried
Keyword(s):  
Communicable Diseases ◽  
World Health ◽  
Sich Eine ◽  
Non Communicable Diseases ◽  
World Health Assembly

ZusammenfassungDie 65. World Health Assembly hat die Bekämpfung nicht-übertragbarer Krankheiten in den Mittelpunkt globaler Aufmerksamkeit und Aktivität gerückt. Da Übergewicht bzw. Adipositas wesentliche Risikofaktoren für einen erheblichen Teil dieser Erkrankungen darstellen, kommt damit der Prävention (aber auch der Therapie) erhöhten Körpergewichtes in der Programmatik der WHO besondere Bedeutung zu. Gleichzeitig führen die hochgesteckten Ziele der WHO in das fundamentale Dilemma, dass es keine Instrumente gibt, die angestrebten Prävalenz- und Reduktionsraten im vorgegebenen Zeitrahmen zu erreichen. Daraus ergeben sich eine Reihe ethischer und sozialer Fragen, unter anderem nach dem zu Grunde gelegten Modell der Adipositas und den impliziten und expliziten Verantwortlichkeiten für ihre Bekämpfung.

Health and Physical Activity in Urban Neighbourhoods. Case Study: Shah Alam City, Selangor, Malaysia

2020 ◽  
Vol 17 (2) ◽  
pp. 11
Author(s):  
Oliver Hoon Leh Ling ◽  
Siti Nur Afiqah Mohamed Musthafa ◽  
Muhammad Solahuddin Hamzah ◽  
Marlyana Azyyati Marzukhi ◽  
Nurul Ashikin Mabahwi
Keyword(s):  
Human Health ◽  
Questionnaire Survey ◽  
Communicable Diseases ◽  
Health Condition ◽  
Environmental Aspects ◽  
Neighbourhood Environment ◽  
Healthy Life ◽  
Non Communicable Diseases ◽  
Urban Neighbourhoods

Environmental health is referring to the health of people in relation to environmental quality. Due to rapid urbanisation, more people are living in urban neighbourhoods. Urban planning and design aspects including the neighbourhood environment are potentially affecting the human healthy lifestyle and health condition. Thus, the relationship between Malaysian neighbourhood environmental aspects and human health has become the concern of this research. One of the neighbourhood units in Shah Alam city had been chosen as the study area for this purpose. Questionnaire survey had been carried out to examine the health condition and physical activeness of residents. Besides, the perception of residents on the quality of neighbourhood environmental aspects also had been collected in the questionnaire survey. The health condition of residents was measured by non-communicable diseases (NCD) and the physical activeness was measured in duration as well as the frequency of physical exercise activities. The study found that the quality of neighbourhood environmental aspects significantly increased the physical activeness of respondents. The physical activeness was positively associated with human health as measured in NCD (heart diseases and high blood pressure, HBP). It shows that neighbourhood environmental (physical and social) aspects are potentially affecting the healthy life of people living in the neighbourhood.Keywords: Healthy life, Neighbourhood environment, Non-communicable diseases (NCD), Physical activeness, Quality.

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