Levels of bisphenol-A in different paper products in Guangzhou, China, and assessment of human exposure via dermal contact

2015 ◽  
Vol 17 (3) ◽  
pp. 667-673 ◽  
Author(s):  
Ruifang Fan ◽  
Biyan Zeng ◽  
Xiaosu Liu ◽  
Chao Chen ◽  
Qinwei Zhuang ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Human Exposure ◽  
Dermal Contact ◽  
Beverage Container ◽  
Food And Beverage

Bisphenol A (BPA) is a chemical widely used both in plastics production as a food and beverage container and in thermal papers as a color developer.

scholarly journals A novel method for rapid and quantitative detection of bisphenol A in urine

2020 ◽  
Author(s):  
Aleksandra Rutkowska ◽  
Aleksandra Olsson ◽  
Jacek Namieśnik ◽  
Andrzej Milewicz ◽  
Jan Krzysztof Ludwicki ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Human Exposure ◽  
Hormone Receptors ◽  
Low Cost ◽  
Medical Diagnostics ◽  
Quantitative Detection ◽  
Adverse Health Effects ◽  
Increased Risk ◽  
Novel Method ◽  
Lifestyle Diseases

Bisphenol A (BPA) is classified as an endocrine disruptor (ED) and it can interact with variety of hormone receptors leading to hormonal disruption and increased risk of various adverse health effects. Reducing human exposure to BPA is one of the main challenges of public health, as it is constantly present in daily life. A low-cost and commonly applied method to enable determination of BPA in the patient's body has yet to be developed. Currently available techniques are expensive, time-consuming, and require access to highly equipped analytical chemistry laboratories. Here we describe a fast and cheap engineered lateral flow assay of our design, to detect of BPA in urine samples. The technology not only provides an opportunity to perform rapid medical diagnostics without the need for an access to the central laboratory but also a means for self-diagnosis by the patient. The addition of β-glucuronidase improves the sensitivity of detection as it releases the free BPA from glucuronide complexes in urine. This invention may become a demonstrated analytical means for lowering human exposure to BPA and probably also to other EDs and consequently, may be useful in decrease of the risk for several lifestyle diseases.

Review of the toxicology, human exposure and safety assessment for bisphenol A diglycidylether (BADGE)

2004 ◽  
Vol 21 (9) ◽  
pp. 905-919 ◽  
Author(s):  
A. Poole ◽  
P. van Herwijnen ◽  
H. Weideli ◽  
M. C. Thomas ◽  
G. Ransbotyn ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Human Exposure ◽  
Safety Assessment

scholarly journals Biomonitoring Studies Should Be Used by Regulatory Agencies to Assess Human Exposure Levels and Safety of Bisphenol A

2010 ◽  
Vol 118 (8) ◽  
pp. 1051-1054 ◽  
Author(s):  
Laura N. Vandenberg ◽  
Ibrahim Chahoud ◽  
Vasantha Padmanabhan ◽  
Francisco J.R. Paumgartten ◽  
Gilbert Schoenfelder
Keyword(s):  
Bisphenol A ◽  
Human Exposure ◽  
Regulatory Agencies ◽  
Exposure Levels

scholarly journals Perinatal Exposure to Bisphenol-A and the Development of Metabolic Syndrome in CD-1 Mice

Endocrinology ◽  
2010 ◽  
Vol 151 (6) ◽  
pp. 2603-2612 ◽  
Author(s):  
Karen K. Ryan ◽  
April M. Haller ◽  
Joyce E. Sorrell ◽  
Stephen C. Woods ◽  
Ronald J. Jandacek ◽  
...  
Keyword(s):  
Bisphenol A ◽  
High Fat Diet ◽  
Perinatal Exposure ◽  
High Fat ◽  
Endocrine Society ◽  
Endocrine Disrupting Chemical ◽  
Obesity And Diabetes ◽  
Food And Beverage ◽  
Relevant Dose ◽  
Increased Susceptibility

Bisphenol-A (BPA) is an endocrine-disrupting chemical used in the production of plastic food and beverage containers, leading to ubiquitous low-dose human exposure. It has been suggested that exposure to even low doses of BPA during development may be associated with increased susceptibility to obesity and diabetes later in life. Despite growing public concern, the existing empirical data are equivocal, prompting The Endocrine Society, the National Institute of Environmental Health Sciences, and others to call for further research. In this study, we tested the hypothesis that perinatal exposure to an ecologically relevant dose of BPA (1 part per billion via the diet) results in increased susceptibility to high-fat diet-induced obesity and glucose intolerance in adult CD-1 mice. The data did not support this hypothesis. In agreement with previous reports, we find that weanling mice exposed to BPA during gestation and lactation are heavier compared with control mice. We also find that BPA mice are longer than controls at 4 wk of age, but these differences are no longer apparent when the mice reach adulthood, even when tested on a high-fat diet. We conclude that this larger size-for-age represents a faster rate of growth early in development rather than an obese, diabetic phenotype in adulthood.

Levels of bisphenol-A in thermal paper receipts from Belgium and estimation of human exposure

2012 ◽  
Vol 435-436 ◽  
pp. 30-33 ◽  
Author(s):  
Tinne Geens ◽  
Leo Goeyens ◽  
Kurunthachalam Kannan ◽  
Hugo Neels ◽  
Adrian Covaci
Keyword(s):  
Bisphenol A ◽  
Human Exposure ◽  
Thermal Paper

scholarly journals Mechanisms of Testicular Disruption from Exposure to Bisphenol A and Phtalates

2020 ◽  
Vol 9 (2) ◽  
pp. 471 ◽  
Author(s):  
Francesco Pallotti ◽  
Marianna Pelloni ◽  
Daniele Gianfrilli ◽  
Andrea Lenzi ◽  
Francesco Lombardo ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Human Exposure ◽  
Clinical Evidence ◽  
Phthalate Esters ◽  
Endocrine Disrupting Chemicals ◽  
Reproductive Function ◽  
Developmental Abnormalities ◽  
Increased Risk ◽  
And Function ◽  
Harmful Effects

Great attention has been paid in recent years to the harmful effects of various chemicals that interfere with our natural hormone balance, collectively known as endocrine-disrupting chemicals (EDCs) or endocrine disruptors. The effects on the reproductive system of bisphenol A (BPA) and phthalates have received particular attention: while they have a short half-life, they are so widespread that human exposure can be considered as continuous. Evidence is often limited to the animal model, disregarding the likelihood of human exposure to a mixture of contaminants. Data from animal models show that maternal exposure probably has harmful effects on the male fetus, with an increased risk of urogenital developmental abnormalities. After birth, exposure is associated with changes in the hypothalamic-pituitary-testicular axis, hindering the development and function of the male genital pathways through the mediation of inflammatory mechanisms and oxidative stress. The epidemiological and clinical evidence, while generally confirming the association between reproductive abnormalities and some phthalate esters and BPA, is more contradictory, with wildly different findings. The aim of this review is therefore to provide an update of the potential mechanisms of the damage caused by BPA and phthalates to reproductive function and a review of the clinical evidence currently available in the literature.

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