A novel dinuclear ruthenium(ii)–copper(ii) complex-based luminescent probe for hydrogen sulfide

2014 ◽  
Vol 43 (34) ◽  
pp. 13055 ◽  
Author(s):  
Zhiqiang Ye ◽  
Xin An ◽  
Bo Song ◽  
Wenzhu Zhang ◽  
Zhichao Dai ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Luminescent Probe ◽  
Dinuclear Ruthenium

scholarly journals Quantitative Monitoring and Visualization of Hydrogen Sulfide In Vivo Using a Luminescent Probe Based on a Ruthenium(II) Complex

2018 ◽  
Vol 57 (15) ◽  
pp. 3999-4004 ◽  
Author(s):  
Zhongbo Du ◽  
Bo Song ◽  
Wenzhu Zhang ◽  
Chengchen Duan ◽  
Yong-Lei Wang ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Luminescent Probe ◽  
Quantitative Monitoring

scholarly journals Quantitative Monitoring and Visualization of Hydrogen Sulfide In Vivo Using a Luminescent Probe Based on a Ruthenium(II) Complex

2018 ◽  
Vol 130 (15) ◽  
pp. 4063-4068 ◽  
Author(s):  
Zhongbo Du ◽  
Bo Song ◽  
Wenzhu Zhang ◽  
Chengchen Duan ◽  
Yong-Lei Wang ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Luminescent Probe ◽  
Quantitative Monitoring

Visualization of exhaled hydrogen sulphide on test paper with an ultrasensitive and time-gated luminescent probe

The Analyst ◽  
2016 ◽  
Vol 141 (16) ◽  
pp. 4919-4925 ◽  
Author(s):  
Ruilong Zhang ◽  
Shijiang Liu ◽  
Jianping Wang ◽  
Guangmei Han ◽  
Linlin Yang ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Hydrogen Sulphide ◽  
Close Association ◽  
Test Paper ◽  
Luminescent Probe

Luminescent chemosensors for hydrogen sulfide (H2S) are of great interest because of the close association of H2S with our health.

A highly sensitive and selective visible-light excitable luminescent probe for singlet oxygen based on a dinuclear ruthenium complex

2017 ◽  
Vol 46 (10) ◽  
pp. 3325-3331 ◽  
Author(s):  
Hong-Ju Yin ◽  
Yan-Ju Liu ◽  
Jie Gao ◽  
Ke-Zhi Wang
Keyword(s):  
Reactive Oxygen Species ◽  
Visible Light ◽  
High Selectivity ◽  
Ruthenium Complex ◽  
Water Soluble ◽  
Oxygen Species ◽  
Luminescent Probe ◽  
Luminescent Probes ◽  
Highly Sensitive ◽  
Dinuclear Ruthenium

A water-soluble dinuclear Ru(ii) complex acts as visible-light excitable luminescent probes for 1O2 with low detection limits of 2.7–3.2 nM and exhibits high selectivity over other reactive oxygen species in both neutral and basic media.

A Dinuclear Ruthenium(II) Complex as a One- and Two-Photon Luminescent Probe for Biological Cu2+Detection

2013 ◽  
Vol 19 (46) ◽  
pp. 15494-15503 ◽  
Author(s):  
Pingyu Zhang ◽  
Lingmin Pei ◽  
Yu Chen ◽  
Wenchao Xu ◽  
Qitian Lin ◽  
...  
Keyword(s):  
Luminescent Probe ◽  
Two Photon ◽  
Dinuclear Ruthenium

Development of Upconversion Luminescent Probe for Ratiometric Sensing and Bioimaging of Hydrogen Sulfide

2014 ◽  
Vol 6 (14) ◽  
pp. 11013-11017 ◽  
Author(s):  
Shujuan Liu ◽  
Lili Zhang ◽  
Tianshe Yang ◽  
Huiran Yang ◽  
Kenneth Yin Zhang ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Luminescent Probe ◽  
Ratiometric Sensing

Endogenous hydrogen sulfide sulfhydrates IKKβ at cysteine 179 to control pulmonary artery endothelial cell inflammation

2019 ◽  
Vol 133 (20) ◽  
pp. 2045-2059 ◽  
Author(s):  
Da Zhang ◽  
Xiuli Wang ◽  
Siyao Chen ◽  
Selena Chen ◽  
Wen Yu ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Endothelial Cell ◽  
Pulmonary Artery ◽  
Cell Model ◽  
Site Directed Mutagenesis ◽  
Critical Event ◽  
Hypertensive Rats ◽  
Pulmonary Artery Endothelial Cell

Abstract Background: Pulmonary artery endothelial cell (PAEC) inflammation is a critical event in the development of pulmonary arterial hypertension (PAH). However, the pathogenesis of PAEC inflammation remains unclear. Methods: Purified recombinant human inhibitor of κB kinase subunit β (IKKβ) protein, human PAECs and monocrotaline-induced pulmonary hypertensive rats were employed in the study. Site-directed mutagenesis, gene knockdown or overexpression were conducted to manipulate the expression or activity of a target protein. Results: We showed that hydrogen sulfide (H2S) inhibited IKKβ activation in the cell model of human PAEC inflammation induced by monocrotaline pyrrole-stimulation or knockdown of cystathionine γ-lyase (CSE), an H2S generating enzyme. Mechanistically, H2S was proved to inhibit IKKβ activity directly via sulfhydrating IKKβ at cysteinyl residue 179 (C179) in purified recombinant IKKβ protein in vitro, whereas thiol reductant dithiothreitol (DTT) reversed H2S-induced IKKβ inactivation. Furthermore, to demonstrate the significance of IKKβ sulfhydration by H2S in the development of PAEC inflammation, we mutated C179 to serine (C179S) in IKKβ. In purified IKKβ protein, C179S mutation of IKKβ abolished H2S-induced IKKβ sulfhydration and the subsequent IKKβ inactivation. In human PAECs, C179S mutation of IKKβ blocked H2S-inhibited IKKβ activation and PAEC inflammatory response. In pulmonary hypertensive rats, C179S mutation of IKKβ abolished the inhibitory effect of H2S on IKKβ activation and pulmonary vascular inflammation and remodeling. Conclusion: Collectively, our in vivo and in vitro findings demonstrated, for the first time, that endogenous H2S directly inactivated IKKβ via sulfhydrating IKKβ at Cys179 to inhibit nuclear factor-κB (NF-κB) pathway activation and thereby control PAEC inflammation in PAH.

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