Development of Upconversion Luminescent Probe for Ratiometric Sensing and Bioimaging of Hydrogen Sulfide

2014 ◽  
Vol 6 (14) ◽  
pp. 11013-11017 ◽  
Author(s):  
Shujuan Liu ◽  
Lili Zhang ◽  
Tianshe Yang ◽  
Huiran Yang ◽  
Kenneth Yin Zhang ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Luminescent Probe ◽  
Ratiometric Sensing

scholarly journals Quantitative Monitoring and Visualization of Hydrogen Sulfide In Vivo Using a Luminescent Probe Based on a Ruthenium(II) Complex

2018 ◽  
Vol 57 (15) ◽  
pp. 3999-4004 ◽  
Author(s):  
Zhongbo Du ◽  
Bo Song ◽  
Wenzhu Zhang ◽  
Chengchen Duan ◽  
Yong-Lei Wang ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Luminescent Probe ◽  
Quantitative Monitoring

scholarly journals Quantitative Monitoring and Visualization of Hydrogen Sulfide In Vivo Using a Luminescent Probe Based on a Ruthenium(II) Complex

2018 ◽  
Vol 130 (15) ◽  
pp. 4063-4068 ◽  
Author(s):  
Zhongbo Du ◽  
Bo Song ◽  
Wenzhu Zhang ◽  
Chengchen Duan ◽  
Yong-Lei Wang ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Luminescent Probe ◽  
Quantitative Monitoring

A Highly Chemically Stable Metal-Organic Framework as a Luminescent Probe for the Regenerable Ratiometric Sensing of pH

2016 ◽  
Vol 22 (37) ◽  
pp. 13023-13027 ◽  
Author(s):  
Jian Wang ◽  
Yang Li ◽  
Min Jiang ◽  
Yanhong Liu ◽  
Lingwen Zhang ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Luminescent Probe ◽  
Ratiometric Sensing ◽  
Metal Organic ◽  
Organic Framework

A novel dinuclear ruthenium(ii)–copper(ii) complex-based luminescent probe for hydrogen sulfide

2014 ◽  
Vol 43 (34) ◽  
pp. 13055 ◽  
Author(s):  
Zhiqiang Ye ◽  
Xin An ◽  
Bo Song ◽  
Wenzhu Zhang ◽  
Zhichao Dai ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Luminescent Probe ◽  
Dinuclear Ruthenium

Visualization of exhaled hydrogen sulphide on test paper with an ultrasensitive and time-gated luminescent probe

The Analyst ◽  
2016 ◽  
Vol 141 (16) ◽  
pp. 4919-4925 ◽  
Author(s):  
Ruilong Zhang ◽  
Shijiang Liu ◽  
Jianping Wang ◽  
Guangmei Han ◽  
Linlin Yang ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Hydrogen Sulphide ◽  
Close Association ◽  
Test Paper ◽  
Luminescent Probe

Luminescent chemosensors for hydrogen sulfide (H2S) are of great interest because of the close association of H2S with our health.

A new strategy to construct a FRET platform for ratiometric sensing of hydrogen sulfide

2015 ◽  
Vol 51 (8) ◽  
pp. 1510-1513 ◽  
Author(s):  
Longwei He ◽  
Weiying Lin ◽  
Qiuyan Xu ◽  
Haipeng Wei
Keyword(s):  
Hydrogen Sulfide ◽  
Ratiometric Sensing ◽  
New Strategy

We introduce a new FRET strategy working in coordination with the ICT process to construct a ratiometric fluorescent H2S sensor.

Endogenous hydrogen sulfide sulfhydrates IKKβ at cysteine 179 to control pulmonary artery endothelial cell inflammation

2019 ◽  
Vol 133 (20) ◽  
pp. 2045-2059 ◽  
Author(s):  
Da Zhang ◽  
Xiuli Wang ◽  
Siyao Chen ◽  
Selena Chen ◽  
Wen Yu ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Endothelial Cell ◽  
Pulmonary Artery ◽  
Cell Model ◽  
Site Directed Mutagenesis ◽  
Critical Event ◽  
Hypertensive Rats ◽  
Pulmonary Artery Endothelial Cell

Abstract Background: Pulmonary artery endothelial cell (PAEC) inflammation is a critical event in the development of pulmonary arterial hypertension (PAH). However, the pathogenesis of PAEC inflammation remains unclear. Methods: Purified recombinant human inhibitor of κB kinase subunit β (IKKβ) protein, human PAECs and monocrotaline-induced pulmonary hypertensive rats were employed in the study. Site-directed mutagenesis, gene knockdown or overexpression were conducted to manipulate the expression or activity of a target protein. Results: We showed that hydrogen sulfide (H2S) inhibited IKKβ activation in the cell model of human PAEC inflammation induced by monocrotaline pyrrole-stimulation or knockdown of cystathionine γ-lyase (CSE), an H2S generating enzyme. Mechanistically, H2S was proved to inhibit IKKβ activity directly via sulfhydrating IKKβ at cysteinyl residue 179 (C179) in purified recombinant IKKβ protein in vitro, whereas thiol reductant dithiothreitol (DTT) reversed H2S-induced IKKβ inactivation. Furthermore, to demonstrate the significance of IKKβ sulfhydration by H2S in the development of PAEC inflammation, we mutated C179 to serine (C179S) in IKKβ. In purified IKKβ protein, C179S mutation of IKKβ abolished H2S-induced IKKβ sulfhydration and the subsequent IKKβ inactivation. In human PAECs, C179S mutation of IKKβ blocked H2S-inhibited IKKβ activation and PAEC inflammatory response. In pulmonary hypertensive rats, C179S mutation of IKKβ abolished the inhibitory effect of H2S on IKKβ activation and pulmonary vascular inflammation and remodeling. Conclusion: Collectively, our in vivo and in vitro findings demonstrated, for the first time, that endogenous H2S directly inactivated IKKβ via sulfhydrating IKKβ at Cys179 to inhibit nuclear factor-κB (NF-κB) pathway activation and thereby control PAEC inflammation in PAH.

Limnological characteristics, community metabolism and management strategies of a coastal sinkhole in Cuba (Cenote Jennifer)

2020 ◽  
Vol 56 ◽  
pp. 24
Author(s):  
Roberto González-De Zayas ◽  
Liosban Lantigua Ponce de León ◽  
Liezel Guerra Rodríguez ◽  
Felipe Matos Pupo ◽  
Leslie Hernández-Fernández
Keyword(s):  
Hydrogen Sulfide ◽  
Primary Productivity ◽  
Major Ions ◽  
Saline Water ◽  
Management Strategies ◽  
Tourist Destination ◽  
Community Metabolism ◽  
Morphological Studies ◽  
Made In ◽  
Limnological Parameters

The Cenote Jennifer is an important and unique aquatic sinkhole in Cayo Coco (Jardines del Rey Tourist Destination) that has brackish to saline water. Two samplings were made in 1998 and 2009, and 4 metabolism community experiments in 2009. Some limnological parameters were measured in both samplings (temperature, salinity, pH, dissolved oxygen major ions, hydrogen sulfide, nutrients and others). Community metabolism was measured through incubated oxygen concentration in clear and dark oxygen bottles. Results showed that the sinkhole limnology depends on rainfall and light incidence year, with some stratification episodes, due to halocline or oxycline presence, rather than thermocline. The sinkhole water was oligotrophic (total nitrogen of 41.5 ± 22.2 μmol l−1 and total phosphorus of 0.3 ± 0.2 μmol l−1) and with low productivity (gross primary productivity of 63.0 mg C m−2 d−1). Anoxia and hypoxia were present at the bottom with higher levels of hydrogen sulfide, lower pH and restricted influence of the adjacent sea (2 km away). To protect the Cenote Jennifer, tourist exploitation should be avoided and more resources to ecological and morphological studies should be allocated, and eventually use this aquatic system only for specialized diving. For conservation purposes, illegal garbage disposal in the surrounding forest should end.

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