Bi-functional NH2-MIL-101(Fe) for one-pot tandem photo-oxidation/Knoevenagel condensation between aromatic alcohols and active methylene compounds

2015 ◽  
Vol 5 (3) ◽  
pp. 1623-1628 ◽  
Author(s):  
Dengke Wang ◽  
Zhaohui Li
Keyword(s):  
Visible Light ◽  
Room Temperature ◽  
Knoevenagel Condensation ◽  
One Pot ◽  
Photo Oxidation ◽  
Aromatic Alcohols ◽  
Active Methylene Compounds ◽  
The One ◽  
Active Methylene

Bi-functional NH2-MIL-101(Fe) can efficiently catalyze the one-pot reaction between aromatic alcohols and active methylene compounds via a tandem photo-oxidation/Knoevenagel condensation under visible light and at room temperature.

scholarly journals A Facile and Catalyst-Free Microwave-Promoted Multicomponent Reaction for the Synthesis of Functionalised 1,4-Dihydropyridines With Superb Selectivity and Yields

2021 ◽  
Vol 9 ◽  
Author(s):  
Nagaraju Kerru ◽  
Suresh Maddila ◽  
Sreekantha B. Jonnalagadda
Keyword(s):  
Spectroscopic Analysis ◽  
High Selectivity ◽  
Water Medium ◽  
One Pot ◽  
Green Protocol ◽  
Catalyst Free ◽  
Active Methylene Compounds ◽  
The One ◽  
Pyrimidine Analogs ◽  
Active Methylene

We report a highly efficient green protocol for developing a novel library of 1,2,4-triazole-tagged 1,4-dihydropyridine analogs through the one-pot process from the four-component fusion of the 1H-1,2,4-triazol-3-amine with different chosen aldehydes, diethyl acetylenedicarboxylate, and active methylene compounds in a water medium under microwave irradiation and catalyst-free conditions. Excellent yields (94–97%) of the target products were achieved with high selectivity with a short reaction time (<12 min) at room temperature. The structures of the synthesized pyrimidine analogs were established by NMR and HRMS spectroscopic analysis. Simple workup, impressive yields, no column chromatography, green solvent, rapid reaction, and excellent functional group tolerance are the benefits of this protocol.

scholarly journals Synthesis of Polyfunctionalized 4H-Pyrans

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Manisha Bihani ◽  
Pranjal P. Bora ◽  
Ghanashyam Bez
Keyword(s):  
Organic Solvents ◽  
Ethyl Acetoacetate ◽  
Room Temperature ◽  
Temperature Reaction ◽  
Chromatographic Purification ◽  
Reaction Conditions ◽  
One Pot ◽  
Experimental Procedure ◽  
Active Methylene Compounds ◽  
Active Methylene

Amberlyst A21 catalyzed one-pot three-component coupling of aldehyde and malononitrile with active methylene compounds such as acetylacetone and ethyl acetoacetate for the synthesis of pharmaceutically important polyfunctionalized 4H-pyrans has been reported. Simple experimental procedure, no chromatographic purification, no hazardous organic solvents, easy recovery and reusability of the catalyst, and room temperature reaction conditions are some of the highlights of this protocol for the synthesis of pharmaceutically relevant focused libraries.

Reductive Knoevenagel Condensation with the Zn–AcOH System

Synthesis ◽  
2020 ◽  
Author(s):  
Ekaterina M. Budynina ◽  
Konstantin L. Ivanov ◽  
Mikhail Ya. Melnikov
Keyword(s):  
Knoevenagel Condensation ◽  
One Pot ◽  
Relative Ease ◽  
Active Methylene Compounds ◽  
Active Methylene

AbstractAn efficient gram-scale one-pot approach to 2-substituted malonates and related structures is developed, starting from commercially available aldehydes and active methylene compounds. The technique combines Knoevenagel condensation with the reduction of the C=C bond in the resulting activated alkenes with the Zn–AcOH system. The relative ease with which the C=C bond reduction occurs can be traced to the accepting abilities of the substituents in the intermediate arylidene malonates.

Uncatalyzed Knoevenagel Condensation in PEG-600 at Room Temperature

2008 ◽  
Vol 61 (9) ◽  
pp. 700 ◽  
Author(s):  
Babasaheb P. Bandgar ◽  
Balaji L. Korbad ◽  
Sachin A. Patil ◽  
Sunita B. Bandgar ◽  
Hemant V. Chavan ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Room Temperature ◽  
Knoevenagel Condensation ◽  
Active Methylene Compounds ◽  
Active Methylene ◽  
Peg 600

A rapid, efficient, and ecofriendly protocol has been developed for the Knoevenagel condensation of active methylene compounds with aromatic, aliphatic, conjugated and heteroaromatic aldehydes in polyethylene glycol-600 (PEG-600) with good to excellent yields.

Reductive alkylation of active methylene compounds with carbonyl derivatives, calcium hydride and a heterogeneous catalyst

2015 ◽  
Vol 13 (25) ◽  
pp. 7067-7075 ◽  
Author(s):  
Carole Guyon ◽  
Marie-Christine Duclos ◽  
Marc Sutter ◽  
Estelle Métay ◽  
Marc Lemaire
Keyword(s):  
Double Bond ◽  
Heterogeneous Catalyst ◽  
Knoevenagel Condensation ◽  
Metal Catalyst ◽  
Calcium Hydride ◽  
Noble Metal Catalyst ◽  
One Pot ◽  
Carbonyl Derivatives ◽  
Active Methylene Compounds ◽  
Active Methylene

A one-pot two-step reaction (Knoevenagel condensation – reduction of the double bond) has been developed using calcium hydride as a reductant in the presence of a supported noble metal catalyst.

A Series of Metal-Organic Frameworks for Selective CO2 Capture and Catalytic Oxidative Carboxylation of Olefins

2018 ◽  
Author(s):  
Huong T. D. Nguyen ◽  
Y B. N. Tran ◽  
Hung N. Nguyen ◽  
Tranh C. Nguyen ◽  
Felipe Gándara ◽  
...  
Keyword(s):  
Room Temperature ◽  
Gas Adsorption ◽  
New Materials ◽  
One Pot ◽  
Acid Gas ◽  
Naphthalene Diimide ◽  
Styrene Carbonate ◽  
Metal Organic ◽  
Adsorption Of Co ◽  
The One

<p>Three novel lanthanide metal˗organic frameworks (Ln-MOFs), namely MOF-590, -591, and -592 were constructed from a naphthalene diimide tetracarboxylic acid. Gas adsorption measurements of MOF-591 and -592 revealed good adsorption of CO<sub>2</sub> (low pressure, at room temperature) and moderate CO<sub>2</sub> selectivity over N<sub>2</sub> and CH<sub>4</sub>. Accordingly, breakthrough measurements were performed on a representative MOF-592, in which the separation of CO<sub>2</sub> from binary mixture containing N<sub>2</sub> and CO<sub>2</sub> was demonstrated without any loss in performance over three consecutive cycles. Moreover, MOF-590, MOF-591, and MOF-592 exhibited catalytic activity in the one-pot synthesis of styrene carbonate from styrene and CO<sub>2</sub> under mild conditions (1 atm CO<sub>2</sub>, 80 °C, and solvent-free). Among the new materials, MOF-590 revealed a remarkable efficiency with exceptional conversion (96%), selectivity (95%), and yield (91%). </p><br>

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