Activatable photodynamic destruction of cancer cells by NIR dye/photosensitizer loaded liposomes

2015 ◽  
Vol 51 (16) ◽  
pp. 3340-3342 ◽  
Author(s):  
Ahu Yuan ◽  
Xiaolei Tang ◽  
Xuefeng Qiu ◽  
Ke Jiang ◽  
Jinhui Wu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Indocyanine Green ◽  
Cancer Cells ◽  
Near Infrared ◽  
Chlorin E6 ◽  
Nir Dye

The phototoxicity of Chlorin e6 (Ce6) for photodynamic therapy (PDT) was found to be effectively suppressed by indocyanine green (ICG), a near infrared (NIR) dye.

Folic Acid Functionalized Chlorin e6-Superparamagnetic Iron Oxide Nanocarriers as a Theranostic Agent for MRI-Guided Photodynamic Therapy

2021 ◽  
Vol 17 (2) ◽  
pp. 205-215
Author(s):  
Zhenbo Sun ◽  
Mingfang Luo ◽  
Jia Li ◽  
Ailing Wang ◽  
Xucheng Sun ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Folic Acid ◽  
Iron Oxide ◽  
Near Infrared ◽  
Biological Fluids ◽  
Superparamagnetic Iron Oxide ◽  
Chlorin E6 ◽  
Theranostic Agent

Imaging-guided cancer theranostic is a promising strategy for cancer diagnostic and therapeutic. Photodynamic therapy (PDT), as an approved treatment modality, is limited by the poor solubility and dispersion of photosensitizers (PS) in biological fluids. Herein, it is demonstrated that superparamagnetic iron oxide (SPIO)-based nanoparticles (SCFs), prepared by conjugated with Chlorin e6 (Ce6) and modified with folic acid (FA) on the surface, can be used as versatile drug delivery vehicles for effective PDT. The nanoparticles are great carriers for photosensitizer Ce6 with an extremely high loading efficiency. In vitro fluorescence imaging and in vivo magnetic resonance imaging (MRI) results indicated that SCFs selectively accumulated in tumor cells. Under near-infrared laser irradiation, SCFs were confirmed to be capable of inducing low cell viability of RM-1 cells In vitro and displaying efficient tumor ablation with negligible side effects in tumor-bearing mice models.

Red-Emitting Upconverting Nanoparticles for Photodynamic Therapy in Cancer Cells Under Near-Infrared Excitation

Small ◽  
2012 ◽  
Vol 9 (11) ◽  
pp. 1929-1938 ◽  
Author(s):  
Gan Tian ◽  
Wenlu Ren ◽  
Liang Yan ◽  
Shan Jian ◽  
Zhanjun Gu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Near Infrared ◽  
Infrared Excitation

scholarly journals Effective Photodynamic Therapy for Colon Cancer Cells Using Chlorin e6 Coated Hyaluronic Acid-Based Carbon Nanotubes

2020 ◽  
Vol 21 (13) ◽  
pp. 4745 ◽  
Author(s):  
Prabhavathi Sundaram ◽  
Heidi Abrahamse
Keyword(s):  
Carbon Nanotubes ◽  
Colon Cancer ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Chlorin E6 ◽  
Therapeutic Modality ◽  
Size Analysis ◽  
Colon Cancer Cells

Colon cancer is the third major cancer contributor to mortality worldwide. Nanosized particles have attracted attention due to their possible contribution towards cancer treatment and diagnosis. Photodynamic therapy (PDT) is a cancer therapeutic modality that involves a light source, a photosensitizer and reactive oxygen species. Carbon nanotubes are fascinating nanocarriers for drug delivery, cancer diagnosis and numerous potential applications due to their unique physicochemical properties. In this study, single walled carbon nanotubes (SWCNTs) were coupled with hyaluronic acid (HA) and chlorin e6 (Ce6) coated on the walls of SWCNTs. The newly synthesized nanobiocomposite was characterized using ultraviolet-visible spectroscopy, Fourier transform electron microscopy (FTIR), X-ray diffraction analysis (XRD), particle size analysis and zeta potential. The loading efficiency of the SWCNTs-HA for Ce6 was calculated. The toxicity of the nanobiocomposite was tested on colon cancer cells using PDT at a fluence of 5 J/cm2 and 10 J/cm2. After 24 h, cellular changes were observed via microscopy, LDH cytotoxicity assay and cell death induction using annexin propidium iodide. The results showed that the newly synthesized nanobiocomposite enhanced the ability of PDT to be a photosensitizer carrier and induced cell death in colon cancer cells.

scholarly journals Broad spectrum antibacterial photodynamic and photothermal therapy achieved with indocyanine green loaded SPIONs under near infrared irradiation

2020 ◽  
Vol 8 (16) ◽  
pp. 4616-4625 ◽  
Author(s):  
K. Bilici ◽  
N. Atac ◽  
A. Muti ◽  
I. Baylam ◽  
O. Dogan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Indocyanine Green ◽  
Broad Spectrum ◽  
Photothermal Therapy ◽  
Bacterial Infections ◽  
Near Infrared ◽  
Alternative Therapies ◽  
Antimicrobial Photodynamic Therapy ◽  
Infrared Irradiation ◽  
Antibiotic Resistant

Antimicrobial photodynamic therapy (aPDT) and antimicrobial photothermal therapy (aPTT) are promising local and effective alternative therapies for antibiotic resistant bacterial infections and biofilms.

scholarly journals Upconversion: Red-Emitting Upconverting Nanoparticles for Photodynamic Therapy in Cancer Cells Under Near-Infrared Excitation (Small 11/2013)

Small ◽  
2013 ◽  
Vol 9 (11) ◽  
pp. 1928-1928 ◽  
Author(s):  
Gan Tian ◽  
Wenlu Ren ◽  
Liang Yan ◽  
Shan Jian ◽  
Zhanjun Gu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Near Infrared ◽  
Infrared Excitation

scholarly journals Efficient delivery of chlorin e6 into ovarian cancer cells with octalysine conjugated superparamagnetic iron oxide nanoparticles for effective photodynamic therapy

2016 ◽  
Vol 4 (47) ◽  
pp. 7741-7748 ◽  
Author(s):  
Li Zhao ◽  
Hongkuan Yang ◽  
Tsukuru Amano ◽  
Hongmei Qin ◽  
Luyi Zheng ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Photodynamic Therapy ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Chlorin E6 ◽  
Ovarian Cancer Cells ◽  
Oxide Nanoparticles ◽  
Efficient Delivery

Chlorin e6, loaded on the surface of SPION-PG-Lys8 through electrostatic attraction, was delivered preferentially into mitochondria of SKOV3 ovarian cancer cells, improving efficacy of photodynamic therapy significantly.

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