Copper-promoted oxidative-fluorination of arylphosphine under mild conditions

2014 ◽  
Vol 50 (74) ◽  
pp. 10879-10882 ◽  
Author(s):  
Na Liu ◽  
Liu-Liang Mao ◽  
Bin Yang ◽  
Shang-Dong Yang
Keyword(s):  
Efficient Method ◽  
Oxidative Coupling ◽  
Mild Conditions

An efficient method for the synthesis of phosphoric fluorideviaoxidative coupling between hydrophosphine oxide and NaF is reported.

Organophosphane-Catalyzed Construction of Functionalized 2-Ylideneoxindoles via Direct β-Acylation

Synthesis ◽  
2021 ◽  
Author(s):  
Wey-Chyng Jeng ◽  
Po-Chung Chien ◽  
Sandip Sambhaji Vagh ◽  
Athukuri Edukondalu ◽  
Wenwei Lin
Keyword(s):  
Intramolecular Cyclization ◽  
Efficient Method ◽  
Bond Cleavage ◽  
Scale Up ◽  
Acyl Chlorides ◽  
Metal Free ◽  
Mild Conditions ◽  
Synthetic Utility ◽  
Mechanistic Investigations ◽  
Synthetic Transformations

We report an efficient method for the direct β-acylation of 2-ylideneoxindoles with acyl chlorides in the presence of base-catalyzed by organophosphanes. A variety of functionalized 2-ylideneoxindoles were prepared in moderate to good yields under metal-free and mild conditions via a tandem phospha-Michael/O-acylation/intramolecular cyclization/ rearrangement sequence. The mechanistic investigations revealed that the C-O bond cleavage on possible betaine intermediate is the key step for the installation of keto-functionality at β-position of 2-ylideneoxindoles in a highly stereospecific manner. The synthetic utility of this protocol could also be proven by scale-up reactions and synthetic transformations of the products.

Efficient Synthesis of 3,4-Disubstituted 7-Azaindoles Employing SEM as a Dual Protecting–Activating Group

Synlett ◽  
2019 ◽  
Vol 30 (20) ◽  
pp. 2273-2278 ◽  
Author(s):  
Piroska Gyárfás ◽  
János Gerencsér ◽  
Warren S. Wade ◽  
László Ürögdi ◽  
Zoltán Novák ◽  
...  
Keyword(s):  
Functional Groups ◽  
Efficient Method ◽  
Reaction Times ◽  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Efficient Synthesis ◽  
Mild Conditions

An efficient method for nucleophilic aromatic substitution on 7-azaindoles has been developed. The reaction is facilitated by the unique dual influence of SEM as both protecting and activating group, permitting mild conditions and short reaction times that are compatible with sensitive functional groups. The method is suitable for the synthesis of a broad range of products, most notably ethers.

KI-Promoted Oxidative Coupling of Styrenes with Indoles under Metal-Free Conditions: Facile Access to C-3 Dicarbonyl Indoles

Synthesis ◽  
2019 ◽  
Vol 51 (18) ◽  
pp. 3511-3519
Author(s):  
Bochao Zhou ◽  
Shiyu Guo ◽  
Zheng Fang ◽  
Zhao Yang ◽  
Chengkou Liu ◽  
...  
Keyword(s):  
Efficient Method ◽  
Oxidative Coupling ◽  
Isotope Labeling ◽  
Cross Coupling ◽  
Metal Free ◽  
Broad Scope ◽  
Plausible Mechanism ◽  
Isotope Labeling Experiments

A new and efficient method for the synthesis of C-3 dicarbonyl indoles via oxidative cross-coupling of styrenes with indoles under metal-free conditions has been developed. Moreover, a broad scope of C-3 dicarbonyl indoles in moderate to good yields were obtained, and a plausible mechanism is proposed based on control and isotope-labeling experiments.

A multicomponent reaction on a ‘free’ KCC-1 catalyst at room temperature under solvent free conditions by visible light

RSC Advances ◽  
2016 ◽  
Vol 6 (59) ◽  
pp. 54236-54240 ◽  
Author(s):  
Seyed Mohsen Sadeghzadeh
Keyword(s):  
Visible Light ◽  
Multicomponent Reaction ◽  
Efficient Method ◽  
Room Temperature ◽  
Solvent Free ◽  
Green Protocol ◽  
Mild Conditions ◽  
Solvent Free Conditions

A green and efficient method for the synthesis of various triazolo[1,2-a]indazoletrione under mild conditions is reported, that making it a genuinely green protocol.

A Highly Efficient Method for the Bromination of Alkenes, Alkynes and Ketones Using Dimethyl Sulfoxide and Oxalyl Bromide

Synthesis ◽  
2018 ◽  
Vol 50 (21) ◽  
pp. 4325-4335 ◽  
Author(s):  
Hongyu Tian ◽  
Baoguo Sun ◽  
Rui Ding ◽  
Jiaqi Li ◽  
Wenyi Jiao ◽  
...  
Keyword(s):  
Dimethyl Sulfoxide ◽  
Efficient Method ◽  
Low Cost ◽  
Reaction Times ◽  
Attractive Alternative ◽  
Mild Conditions ◽  
Highly Efficient

The pairing of DMSO and oxalyl bromide is reported as a highly efficient brominating reagent for various alkenes, alkynes and ketones. This bromination approach demonstrates remarkable advantages, such as mild conditions, low cost, short reaction times, provides excellent yields in most cases and represents a very attractive alternative for the preparation of dibromides and α-bromoketones.

Methyl ester synthesis catalyzed by nanoporous gold: from 10−9 Torr to 1 atm

2015 ◽  
Vol 5 (2) ◽  
pp. 1299-1306 ◽  
Author(s):  
Lu-Cun Wang ◽  
Kara J. Stowers ◽  
Branko Zugic ◽  
Monika M. Biener ◽  
Juergen Biener ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Oxidative Coupling ◽  
Pressure Range ◽  
Methyl Esters ◽  
Nanoporous Gold ◽  
Selective Synthesis ◽  
Ester Synthesis ◽  
Mild Conditions ◽  
Wide Pressure Range ◽  
Wide Pressure

Highly selective synthesis of methyl esters can be achieved by oxidative coupling of methanol and aldehydes (acetaldehyde, butyraldehyde) under mild conditions using unsupported nanoporous gold catalysts over a wide pressure range (from 10−9 Torr to 1 atm).

Efficient Method for the Synthesis of Dibenzo[b,f]thiepin-10-ones under Mild Conditions

Heterocycles ◽  
2007 ◽  
Vol 71 (2) ◽  
pp. 389 ◽  
Author(s):  
William J. Welsh ◽  
Qiang Zhang ◽  
Youyi Peng
Keyword(s):  
Efficient Method ◽  
Mild Conditions

scholarly journals New simple synthesis of ring-fused 4-alkyl-4H-3,1-benzothiazine-2-thiones: Direct formation from carbon disulfide and (E)-3-(2-aminoaryl)acrylates or (E)-3-(2-aminoaryl)acrylonitriles

2013 ◽  
Vol 9 ◽  
pp. 460-466 ◽  
Author(s):  
Qiuping Ding ◽  
Yuqing Lin ◽  
Guangni Ding ◽  
Fumin Liao ◽  
Xiaoyan Sang ◽  
...  
Keyword(s):  
Carbon Disulfide ◽  
Efficient Method ◽  
Simple Synthesis ◽  
Metal Catalyst ◽  
Mild Conditions ◽  
Wide Range ◽  
Direct Formation

A new simple and efficient method to construct ring-fused 4-alkyl-4H-3,1-benzothiazine-2-thione derivatives has been developed from carbon disulfide and (E)-3-(2-aminoaryl)acrylates or (E)-3-(2-aminoaryl)acrylonitriles under mild conditions, without the need for a metal catalyst. The newly developed method tolerates a wide range of substrates in moderate to excellent yields. Moreover, this method is advantageous over previous ones for the easy synthesis of reactants.

Synthesis of Malononitrile-Substituted Diarylmethines via 1,6-Addition of Masked Acyl Cyanides to para-Quinone Methides

Synthesis ◽  
2017 ◽  
Vol 50 (04) ◽  
pp. 872-880 ◽  
Author(s):  
Dieter Enders ◽  
Kun Zhao ◽  
Ying Zhi ◽  
Ai Wang
Keyword(s):  
Bioactive Compounds ◽  
Efficient Method ◽  
Conjugate Addition ◽  
Quinone Methides ◽  
Mild Conditions ◽  
Synthetic Utility

An efficient method for the synthesis of malononitrile-substituted­ diarylmethines through 1,6-conjugate addition of para-quinone­ methides with masked acyl cyanide (MAC) reagents has been developed. Under mild conditions, the scalable reaction occurs in good to excellent yields providing a straightforward access to a series of malononitrile-substituted diarylmethines. The synthetic utility of this protocol has been demonstrated in the synthesis of bioactive compounds.

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