scholarly journals Near IR excitation of heavy atom free Bodipy photosensitizers through the intermediacy of upconverting nanoparticles

2014 ◽  
Vol 50 (64) ◽  
pp. 8896-8899 ◽  
Author(s):  
Seda Demirel Topel ◽  
Gunseli Turgut Cin ◽  
Engin U. Akkaya
Keyword(s):  
Singlet Oxygen ◽  
Heavy Atom ◽  
Near Ir

Orthogonal dimers of Bodipy can be effectively excited to generate singlet oxygen at 980 nm.

Achieving high singlet-oxygen generation by applying the heavy-atom effect to thermally activated delayed fluorescent materials

2021 ◽  
Author(s):  
Ya-Fang Xiao ◽  
Jia-Xiong Chen ◽  
Wen-Cheng Chen ◽  
Xiuli Zheng ◽  
Chen Cao ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Heavy Atom ◽  
Synergetic Effect ◽  
Heavy Atom Effect ◽  
Oxygen Generation ◽  
Thermally Activated ◽  
Singlet Oxygen Generation ◽  
Fluorescent Materials ◽  
Atom Effect

Applying the heavy-atom effect to TADF photosensitizers achieves ultra-high 1O2 generation (ФΔ = 0.91) by the synergetic effect of small ΔEST and considerable SOC.

Singlet oxygen generation of subphthalocyanine-fused dimer and trimer

2020 ◽  
Vol 24 (01n03) ◽  
pp. 211-219
Author(s):  
Rei Fujishiro ◽  
Hayato Sonoyama ◽  
Yuki Ide ◽  
Takuya Fujimura ◽  
Ryo Sasai ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Quantum Yields ◽  
Absorption Bands ◽  
Low Light ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Near Ir ◽  
Interesting Class ◽  
High Fluorescence ◽  
Significant Wavelength

Subphthalocyanine (SubPc) macrocycles are known as an interesting class of nonplanar aromatic dyes. Despite documented high fluorescence and singlet oxygen quantum yields, the properties of SubPcs in photodynamic therapy (PDT) are underestimated, because their absorption bands do not reach a significant wavelength range. With this in mind, we combined a SubPc ring and a SubPc ring by introducing a common benzene ring and obtained a SubPc dimer (2) and trimer (3) with the Q-band at the near-IR region, owing to the expansion of the [Formula: see text] electron conjugated system. In this study, we reported 1O2 generation abilities of 2 and 3based on the applied absolute singlet oxygen quantum yields ([Formula: see text]absolute). Subsequent research revealed that 2 and 3 showed the potential to generate 1O2 to not only in toluene but also in DMSO. Although the photocytotoxicity of 2 and 3 were investigated upon photo-irradiation with a low light dose of approximately 1.5 J/cm2, 2 and 3 showed almost negligible toxic properties toward HEp2 cells.

scholarly journals Heavy atom-free semiconducting polymer with high singlet oxygen quantum yield for prostate cancer synergistic phototherapy

2019 ◽  
Vol 3 (6) ◽  
pp. 1123-1127 ◽  
Author(s):  
Jian Shen ◽  
Jianjiao Chen ◽  
Zhen Ke ◽  
Dengfeng Zou ◽  
Liguo Sun ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
Heavy Atom ◽  
Semiconducting Polymer ◽  
Prostate Cancer Therapy

Heavy atom free NDNT have a great potential for prostate cancer therapy both in vitro and in vivo.

Heavy-atom modified near-IR fluorescent dyes for DNA sequencing applications: synthesis and photophysical characterization

1997 ◽  
Author(s):  
James H. Flanagan, Jr. ◽  
Sarah E. Romero ◽  
Benjamin L. Legendre, Jr. ◽  
Robert P. Hammer ◽  
Steven A. Soper
Keyword(s):  
Dna Sequencing ◽  
Fluorescent Dyes ◽  
Heavy Atom ◽  
Near Ir

scholarly journals Heavy Atom Free Singlet Oxygen Generation: Doubly Substituted Configurations Dominate S1 States of Bis-BODIPYs

2012 ◽  
Vol 77 (10) ◽  
pp. 4516-4527 ◽  
Author(s):  
Selin Duman ◽  
Yusuf Cakmak ◽  
Safacan Kolemen ◽  
Engin U. Akkaya ◽  
Yavuz Dede
Keyword(s):  
Singlet Oxygen ◽  
Heavy Atom ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

Observation of collision-induced near-IR emission of singlet oxygen O2 a1Δg generated by visible light excitation of gaseous O2 dimol

2009 ◽  
Vol 471 (1-3) ◽  
pp. 45-49 ◽  
Author(s):  
Eiji Furui ◽  
Nobuyuki Akai ◽  
Akira Ida ◽  
Akio Kawai ◽  
Kazuhiko Shibuya
Keyword(s):  
Visible Light ◽  
Singlet Oxygen ◽  
Near Ir ◽  
Light Excitation ◽  
Ir Emission

scholarly journals A P-61 Black Widow Inspired Palladium Biladiene Complex for Efficient Sensitization of Singlet Oxygen Using Visible Light

Photochem ◽  
2022 ◽  
Vol 2 (1) ◽  
pp. 58-68
Author(s):  
Anthony T. Rice ◽  
Glenn P. A. Yap ◽  
Joel Rosenthal
Keyword(s):  
Visible Light ◽  
Singlet Oxygen ◽  
Heavy Atom ◽  
Spectroscopic Properties ◽  
Quantum Yields ◽  
Black Widow ◽  
Oxygen Generation ◽  
Promising Treatment ◽  
Cancerous Cells ◽  
Sensitization Efficiency

Photodynamic therapy (PDT) is a promising treatment option that ablates cancerous cells and tumors via photoinduced sensitization of singlet oxygen. Over the last few decades, much work has been devoted to the development of new photochemotherapeutic agents for PDT. A wide variety of macrocyclic tetrapyrrole based photosensitizers have been designed, synthesized and characterized as PDT agents. Many of these complexes have a variety of issues that pose a barrier to their use in humans, including biocompatibility, inherent toxicity, and synthetic hurdles. We have developed a non-traditional, non-cyclic, and non-aromatic tetrapyrrole ligand scaffold, called the biladiene (DMBil1), as an alternative to these traditional photosensitizer complexes. Upon insertion of a heavy atom such as Pd2+ center, Pd[DMBil1] generates singlet oxygen in substantial yields (ΦΔ = 0.54, λexc = 500 nm) when irradiated with visible light. To extend the absorption profile for Pd[DMBil1] deeper into the phototherapeutic window, the tetrapyrrole was conjugated with alkynyl phenyl groups at the 2- and 18-positions (Pd[DMBil2-PE]) resulting in a significant redshift while also increasing singlet oxygen generation (ΦΔ = 0.59, 600 nm). To further modify the dialkynyl-biladiene scaffold, we conjugated a 1,8-diethynylanthracene with to the Pd[DMBil1] tetrapyrrole in order to further extend the compound’s π-conjugation in a cyclic loop that spans the entire tetrapyrrole unit. This new compound (Pd[DMBil2-P61]) is structurally reminiscent of the P61 Black Widow aircraft and absorbs light into the phototherapeutic window (600–900 nm). In addition to detailing the solid-state structure and steady-state spectroscopic properties for this new biladiene, photochemical sensitization studies demonstrated that Pd[DMBil2-P61] can sensitize the formation of 1O2 with quantum yields of ΦΔ = 0.84 upon irradiation with light λ = 600 nm. These results distinguish the Pd[DMBil2-P61] platform as the most efficient biladiene-based singlet oxygen photosensitizer developed to date. When taken together, the improved absorption in the phototherapeutic window and high singlet oxygen sensitization efficiency of Pd[DMBil2-P61] mark this compound as a promising candidate for future study as an agent of photodynamic cancer therapy.

A “Multi‐Heavy‐Atom” Approach toward Biphotonic Photosensitizers with Improved Singlet‐Oxygen Generation Properties

2019 ◽  
Vol 25 (38) ◽  
pp. 9026-9034 ◽  
Author(s):  
Margaux Galland ◽  
Tangui Le Bahers ◽  
Akos Banyasz ◽  
Noëlle Lascoux ◽  
Alain Duperray ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Heavy Atom ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation
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