A DNA-templated synthesis of encoded small molecules by DNA self-assembly

2014 ◽  
Vol 50 (75) ◽  
pp. 10997-10999 ◽  
Author(s):  
Cheng Cao ◽  
Peng Zhao ◽  
Ze Li ◽  
Zitian Chen ◽  
Yanyi Huang ◽  
...  
Keyword(s):  
Small Molecules ◽  
Self Assembly ◽  
Templated Synthesis ◽  
Dna Template

Encoded libraries can be prepared by DNA-templated synthesis without any DNA template.

Enzyme-Instructed Self-assembly in Biological Milieu for Theranostics Purpose

2019 ◽  
Vol 26 (8) ◽  
pp. 1351-1365 ◽  
Author(s):  
Zhentao Huang ◽  
Qingxin Yao ◽  
Simin Wei ◽  
Jiali Chen ◽  
Yuan Gao
Keyword(s):  
Small Molecules ◽  
Precision Medicine ◽  
Self Assembly ◽  
Public Healthcare ◽  
Enzymatic Conversion ◽  
Vaccine Adjuvants ◽  
New Paradigm ◽  
Cancer Treatments ◽  
The Past ◽  
Biological Milieu

Precision medicine is in an urgent need for public healthcare. Among the past several decades, the flourishing development in nanotechnology significantly advances the realization of precision nanomedicine. Comparing to well-documented nanoparticlebased strategy, in this review, we focus on the strategy using enzyme instructed selfassembly (EISA) in biological milieu for theranostics purpose. In principle, the design of small molecules for EISA requires two aspects: (1) the substrate of enzyme of interest; and (2) self-assembly potency after enzymatic conversion. This strategy has shown its irreplaceable advantages in nanomedicne, specifically for cancer treatments and Vaccine Adjuvants. Interestingly, all the reported examples rely on only one kind of enzymehydrolase. Therefore, we envision that the application of EISA strategy just begins and will lead to a new paradigm in nanomedicine.

Computational and Experimental Binding Mechanism of DNA-drug Interactions

2019 ◽  
Vol 24 (32) ◽  
pp. 3739-3757 ◽  
Author(s):  
Chandrabose Selvaraj ◽  
Sanjeev K. Singh
Keyword(s):  
Small Molecules ◽  
Self Assembly ◽  
Genetic Material ◽  
Dna Interaction ◽  
Significant Feature ◽  
Drug Molecules ◽  
Potential Applications ◽  
Novel Drug ◽  
Groove Binders ◽  
Molecular Docking And Dynamics

Nucleic acid is the key unit and a predominant genetic material for interpreting the fundamental basis of genetic information in an organism and now it is used for the evolution of a novel group of therapeutics. To identify the potential impact on the biological science, it receives high recognition in therapeutic applications. Due to its selective recognition of molecular targets and pathways, DNA significantly imparts tremendous specificity of action. Examining the properties of DNA holds numerous advantages in assembly, interconnects, computational elements, along with potential applications of DNA self-assembly and scaffolding include nanoelectronics, biosensors, and programmable/autonomous molecular machines. The interaction of low molecular weight, small molecules with DNA is a significant feature in pharmacology. Based on the mode of binding mechanisms, small molecules are categorized as intercalators and groove binders having a significant role in target-based drug development. The understanding mechanism of drug-DNA interaction plays an important role in the development of novel drug molecules with more effective and lesser side effects. This article attempts to outline those interactions of drug-DNA with both experimental and computational advances, including ultraviolet (UV) -visible spectroscopy, fluorescent spectroscopy, circular dichroism, nuclear magnetic resonance (NMR), molecular docking and dynamics, and quantum mechanical applications.

Investigating Zigzag Film Growth Behaviors in Layer-by-Layer Self-Assembly of Small Molecules through a High-Gravity Technique

2015 ◽  
Vol 7 (33) ◽  
pp. 18824-18831 ◽  
Author(s):  
Mengjiao Cheng ◽  
Chao Jiang ◽  
Caijun Luo ◽  
Yajun Zhang ◽  
Feng Shi
Keyword(s):  
Small Molecules ◽  
Self Assembly ◽  
Film Growth ◽  
High Gravity ◽  
Layer By Layer

scholarly journals RAFT-photomediated PISA in dispersion: mechanism, optical properties and application in templated synthesis

2019 ◽  
Vol 10 (18) ◽  
pp. 2316-2326 ◽  
Author(s):  
Vitalii Tkachenko ◽  
Camélia Matei Ghimbeu ◽  
Cyril Vaulot ◽  
Loïc Vidal ◽  
Julien Poly ◽  
...  
Keyword(s):  
Optical Properties ◽  
Diblock Copolymer ◽  
Self Assembly ◽  
Templated Synthesis ◽  
Dispersion Mechanism

Diblock copolymer nanoparticles were prepared by photomediated polymerization-induced self-assembly (“photo-PISA”) in dispersion.

scholarly journals Aqueous interfacial gels assembled from small molecule supramolecular polymers

2017 ◽  
Vol 8 (2) ◽  
pp. 1350-1355 ◽  
Author(s):  
Alexander S. Groombridge ◽  
Aniello Palma ◽  
Richard M. Parker ◽  
Chris Abell ◽  
Oren A. Scherman
Keyword(s):  
Small Molecules ◽  
Small Molecule ◽  
Self Assembly ◽  
Hyperbranched Polymer ◽  
Soft Matter ◽  
Supramolecular Polymers ◽  
Supramolecular Network ◽  
Self Healing ◽  
Liquid Interfaces ◽  
Stimuli Responsive

The successful self-assembly of a stimuli-responsive aqueous supramolecular hyperbranched polymer from small molecules and the macrocyclic host cucurbit[8]uril (CB[8]) is reported. This self-healing supramolecular network can act as a soft matter barrier at liquid–liquid interfaces.

Self-assembly of amylose, protein, and lipid as a nanoparticle carrier of hydrophobic small molecules

2015 ◽  
pp. 263-271 ◽  
Author(s):  
Genyi Zhang ◽  
Deepak Bhopatkar ◽  
Bruce R. Hamaker ◽  
Osvaldo H. Campanella
Keyword(s):  
Small Molecules ◽  
Self Assembly

Small molecule-mediated self-assembly behaviors of Pluronic block copolymers in aqueous solution: impact of hydrogen bonding on the morphological transition of Pluronic micelles

Soft Matter ◽  
2020 ◽  
Vol 16 (1) ◽  
pp. 142-151 ◽  
Author(s):  
Haiyan Luo ◽  
Kun Jiang ◽  
Xiangfeng Liang ◽  
Huizhou Liu ◽  
Yingbo Li
Keyword(s):  
Aqueous Solution ◽  
Hydrogen Bonding ◽  
Block Copolymers ◽  
Small Molecules ◽  
Small Molecule ◽  
Propyl Gallate ◽  
Self Assembly ◽  
Morphological Transition ◽  
Propyl Paraben ◽  
Pluronic P123

The influence of hydrogen bonding on the morphological transition of Pluronic P123 micelles is experimentally and theoretically investigated by introducing three small molecules, i.e. propyl benzoate (PB), propyl paraben (PP) and propyl gallate (PG).

scholarly journals Modulation of Amyloidogenic Protein Self-Assembly Using Tethered Small Molecules

2020 ◽  
Vol 142 (49) ◽  
pp. 20845-20854
Author(s):  
Emma E. Cawood ◽  
Nicolas Guthertz ◽  
Jessica S. Ebo ◽  
Theodoros K. Karamanos ◽  
Sheena E. Radford ◽  
...  
Keyword(s):  
Small Molecules ◽  
Self Assembly ◽  
Amyloidogenic Protein

Self-Assembly of Thiourea-Crosslinked Graphene Oxide Framework Membranes toward Separation of Small Molecules

2018 ◽  
Vol 30 (16) ◽  
pp. 1705775 ◽  
Author(s):  
Jingjing Yang ◽  
Dian Gong ◽  
Guihua Li ◽  
Gaofeng Zeng ◽  
Qiyan Wang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Small Molecules ◽  
Self Assembly
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