Cell membrane-inspired polymeric micelles as carriers for drug delivery

2015 ◽  
Vol 3 (3) ◽  
pp. 490-499 ◽  
Author(s):  
Gongyan Liu ◽  
Quanqing Luo ◽  
Haiqi Gao ◽  
Yuan Chen ◽  
Xing Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Cell Membrane ◽  
Polymeric Micelles ◽  
Drug Carriers

Cell membrane-inspired polymeric micelles were designed as drug carriers for cancer therapy.

scholarly journals Active Targeted Nanoparticles for Delivery of Poly(ADP-ribose) Polymerase (PARP) Inhibitors: A Preliminary Review

2021 ◽  
Vol 22 (19) ◽  
pp. 10319
Author(s):  
Saman Sargazi ◽  
Mahwash Mukhtar ◽  
Abbas Rahdar ◽  
Mahmood Barani ◽  
Sadanad Pandey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Dna Repair ◽  
Cancer Cells ◽  
Polymeric Micelles ◽  
Drug Carriers ◽  
Antioxidant Response ◽  
Parp Inhibitors ◽  
Preliminary Review ◽  
Repair Gene ◽  
Dna Repair Gene

Nanotechnology has revolutionized novel drug delivery strategies through establishing nanoscale drug carriers, such as niosomes, liposomes, nanomicelles, dendrimers, polymeric micelles, and nanoparticles (NPs). Owing to their desirable cancer-targeting efficacy and controlled release, these nanotherapeutic modalities are broadly used in clinics to improve the efficacy of small-molecule inhibitors. Poly(ADP-ribose) polymerase (PARP) family members engage in various intracellular processes, including DNA repair, gene transcription, signal transduction, cell cycle regulation, cell division, and antioxidant response. PARP inhibitors are synthetic small-molecules that have emerged as one of the most successful innovative strategies for targeted therapy in cancer cells harboring mutations in DNA repair genes. Despite these advances, drug resistance and unwanted side effects are two significant drawbacks to using PARP inhibitors in the clinic. Recently, the development of practical nanotechnology-based drug delivery systems has tremendously improved the efficacy of PARP inhibitors. NPs can specifically accumulate in the leaky vasculature of the tumor and cancer cells and release the chemotherapeutic moiety in the tumor microenvironment. On the contrary, NPs are usually unable to permeate across the body’s normal organs and tissues; hence the toxicity is zero to none. NPs can modify the release of encapsulated drugs based on the composition of the coating substance. Delivering PARP inhibitors without modulation often leads to the toxic effect; therefore, a delivery vehicle is essential to encapsulate them. Various nanocarriers have been exploited to deliver PARP inhibitors in different cancers. Through this review, we hope to cast light on the most innovative advances in applying PARP inhibitors for therapeutic purposes.

Drug delivery and innovative pharmaceutical development in mimicking the red blood cell membrane

2015 ◽  
Vol 31 (5) ◽  
Author(s):  
Sumaira Naeem ◽  
Lik Voon Kiew ◽  
Chung Lip Yong ◽  
Yin Teo Yin ◽  
Misni Bin Misran
Keyword(s):  
Drug Delivery ◽  
Cell Membrane ◽  
Drug Carriers ◽  
Reticuloendothelial System ◽  
Bilayer Membrane ◽  
Red Cell ◽  
Red Cell Membrane ◽  
Distinctive Features ◽  
Stealth Liposomes ◽  
Accelerated Blood Clearance

AbstractCirculation half-life has become one of the major design considerations in nanoparticle drug delivery systems. By taking cues for designing long circulating carriers from natural entities such as red blood cells (RBCs) has been explored for many years. Among all the cellular carriers including leukocytes, fibroblasts, islets, and hepatocytes, RBCs offer several distinctive features. The present review underlines a discussion on the applications of different RBC carriers (RBC mimics) which can evade the body’s reticuloendothelial system overcoming many barriers such as size, shape, accelerated blood clearance, mechanical properties, control over particle characteristics, and surface chemistry. Bilayer membrane liposomes infusing phospholipids have long been synthesized to mimic bioconcave RBC carriers using the notion of stealth liposomes. This is not a comprehensive review; some illustrative examples are given on how they are currently obtained. A special attention is devoted to the RBC mimics from polymers, red cell membrane ghosts, and the red cell membrane enclosing polymeric cores as potential drug carriers. The present research reveals the achievement of RBC surface charge to accord with the immune system as a game of hide and seek in a much promising way in the light of its pharmaceutical applications.

scholarly journals pH-Responsive hyperbranched polypeptides based on Schiff bases as drug carriers for reducing toxicity of chemotherapy

RSC Advances ◽  
2020 ◽  
Vol 10 (23) ◽  
pp. 13889-13899
Author(s):  
Rui Yan ◽  
Xinyi Liu ◽  
Junjie Xiong ◽  
Qiyi Feng ◽  
Junhuai Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Schiff Bases ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Ph Responsive ◽  
Excellent Stability

Polymeric micelles have great potential in drug delivery systems because of their multifunctional adjustability, excellent stability, and biocompatibility.

scholarly journals A Review on Nanocarriers for Cancer Targeted Drug Delivery

2020 ◽  
Vol 63 (3) ◽  
pp. 239-246
Author(s):  
Fariha Lrfan ◽  
Tahir Lqbal ◽  
Nafisa Malik ◽  
Mohsin Ljaz
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Effective Drug ◽  
Targeted Drug

Nanoparticles in the drugs are useful for the treatment of cancer due to their unique properties and can act as drug carriers in different ways. Unlike the traditional chemotherapy, the entrance of nanotechnology enabled wide applications in treatment of cancer. Although nanoparticles provides safe and effective drug delivery systems but the factor of toxicity still limits the utilisation of several nanoparticles. The properties of nanodrug carriers are controllable by various factors. The use of nanoparticles in cancer therapy by drug delivery and their advantages as been reviewed.      

scholarly journals Bioinspired Membrane-Coated Nanoplatform for Targeted Tumor Immunotherapy

2022 ◽  
Vol 11 ◽  
Author(s):  
Dan Mu ◽  
Pan He ◽  
Yesi Shi ◽  
Lai Jiang ◽  
Gang Liu
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Cell Membrane ◽  
Tumor Targeting ◽  
Recent Progress ◽  
Tumor Immunotherapy ◽  
Immune Microenvironment ◽  
Research Directions ◽  
Tumor Immune Microenvironment ◽  
New Research

Immunotherapy can effectively activate the immune system and reshape the tumor immune microenvironment, which has been an alternative method in cancer therapy besides surgery, radiotherapy, and chemotherapy. However, the current clinical outcomes are not satisfied due to the lack of targeting of the treatment with some unexpected damages to the human body. Recently, cell membrane-based bioinspired nanoparticles for tumor immunotherapy have attracted much attention because of their superior immune regulating, drug delivery, excellent tumor targeting, and biocompatibility. Together, the article reviews the recent progress of cell membrane-based bioinspired nanoparticles for immunotherapy in cancer treatment. We also evaluate the prospect of bioinspired nanoparticles in immunotherapy for cancer. This strategy may open up new research directions for cancer therapy.

scholarly journals Cell-mediated and cell membrane-coated nanoparticles for drug delivery and cancer therapy

2020 ◽  
Author(s):  
Serkan Yaman ◽  
Uday Chintapula ◽  
Edgar Rodriguez ◽  
Harish Ramachandramoorthy ◽  
Kytai T. Nguyen
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Cell Membrane ◽  
Coated Nanoparticles

Construction of biomimetic-responsive nanocarriers and their applications in tumor targeting

2022 ◽  
Vol 22 ◽  
Author(s):  
Xuexia Tian ◽  
Anhua Shi ◽  
Junzi Wu
Keyword(s):  
Drug Delivery ◽  
Immune System ◽  
Cancer Therapy ◽  
Cell Membrane ◽  
Tumor Targeting ◽  
Cell Membranes ◽  
Drug Loading ◽  
Hybrid Cell ◽  
Tumor Treatment ◽  
Wide Range

Backgroud: At present, the tumor is still the leading cause of death. Biomimetic nanocarriers for precision cancer therapy are attracting increasing attention. Nanocarriers with a good biocompatible surface could reduce the recognition and elimination of nanoparticles as foreign substances by the immune system, offer specific targeting, and improve the efficacy of precision medicine for tumors, thereby providing outstanding prospects for application in cancer therapy. In particular, cell membrane biomimetic camouflaged nanocarriers have become a research hotspot because of their excellent biocompatibility, prolonged circulation in the blood, and tumor targeting. Objective: To summarize the biological targeting mechanisms of different cell membrane-encapsulated nanocarriers in cancer therapy. In this article, the characteristics, application, and stage of progress of bionic encapsulated nanocarriers for different cell membranes are discussed, as are the field’s developmental prospects. Method: The findings on the characteristics of bionic encapsulated nanocarriers for different cell membranes and tumor treatment have been analyzed and summarized. Results: Biomimetic nanosystems based on various natural cell and hybrid cell membranes have been shown to efficiently control targeted drug delivery systems. They can reduce immune system clearance, prolong blood circulation time, and improve drug loading and targeting, thereby enhancing the diagnosis and treatment of tumors and reducing the spread of CTCs. Conclusion: ：With advances in the development of biomimetic nanocarrier DDSs, novel ideas for tumor treatment and drug delivery have been developed. However, there are still some problems in biomimetic nanosystems. Therefore, it needs to be optimized through further research, from the laboratory to the clinic for the benefit of a wide range of patients.

Cell Membrane-Camouflaged Nanoparticles as Drug Carriers for Cancer Therapy

2019 ◽  
Author(s):  
Cheng-Hui Xu ◽  
Peng-Ju Ye ◽  
Yang-Chun Zhou ◽  
Dong-Xiu He ◽  
Cui-Yun Yu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cell Membrane ◽  
Drug Carriers

scholarly journals Hyaluronidase-Responsive Mesoporous Silica Nanoparticles with Dual-Imaging and Dual-Target Function

Cancers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 697 ◽  
Author(s):  
Zhi-Yuan Wu ◽  
Cheng-Chang Lee ◽  
Hsiu-Mei Lin
Keyword(s):  
Drug Delivery ◽  
Cell Membrane ◽  
Mesoporous Silica ◽  
Cancer Cells ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Dual Imaging ◽  
Nucleus Target

Nanoparticle-based drug delivery systems are among the most popular research topics in recent years. Compared with traditional drug carriers, mesoporous silica nanoparticles (MSN) offer modifiable surfaces, adjustable pore sizes and good biocompatibility. Nanoparticle-based drug delivery systems have become a research direction for many scientists. With the active target factionalized, scientists could deliver drug carriers into cancer cells successfully. However, drugs in cancer cells could elicit drug resistance and induce cell exocytosis. Thus, the drug cannot be delivered to its pharmacological location, such as the nucleus. Therefore, binding the cell membrane and the nuclear target on the nanomaterial so that the anticancer drug can be delivered to its pharmacological action site is our goal. In this study, MSN-EuGd was synthesized by doping Eu3+ and Gd3+ during the synthesis of MSN. The surface of the material was then connected to the TAT peptide as the nucleus target for targeting the cancer nucleus and then loaded with the anticancer drug camptothecin (CPT). Then, the surface of MSN-EuGd was bonded to the hyaluronic acid as an active target and gatekeeper. With this system, it is possible and desirable to achieve dual imaging and dual targeting, as well as to deliver drugs to the cell nucleus under a hyaluronidase-controlled release. The experimental approach is divided into three parts. First, we conferred the material with fluorescent and magnetic dual-imaging property by doping Eu3+ and Gd3+ into the MSN. Second, modification of the cell membrane target molecule and the nucleus target molecule occurred on the surface of the nanoparticle, making the nanoparticle a target drug carrier. Third, the loading of drug molecules into the carrier gave the entire carrier a specific target profile and enabled the ability to treat cancer. In this study, we investigated the basic properties of the drug carrier, including physical properties, chemical properties, and in vitro tests. The result showed that we have successfully designed a drug delivery system that recognizes normal cells and cancer cells and has good anticancer effects.

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