scholarly journals MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

2015 ◽  
Vol 3 (2) ◽  
pp. 246-249 ◽  
Author(s):  
Daniela Kalafatovic ◽  
Max Nobis ◽  
Nadeem Javid ◽  
Pim W. J. M. Frederix ◽  
Kurt I. Anderson ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Slow Release ◽  
Peptide Amphiphiles ◽  
Hydrophobic Anticancer Drugs

MMP-9 responsive peptide amphiphiles designed for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.

Injectable micellar supramolecular hydrogel for delivery of hydrophobic anticancer drugs

2016 ◽  
Vol 27 (4) ◽  
Author(s):  
CuiXiang Fu ◽  
XiaoXiao Lin ◽  
Jun Wang ◽  
XiaoQun Zheng ◽  
XingYi Li ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Supramolecular Hydrogel ◽  
Hydrophobic Anticancer Drugs

Novel amphiphilic chitosan micelles as carriers for hydrophobic anticancer drugs

2020 ◽  
Vol 112 ◽  
pp. 110920 ◽  
Author(s):  
Andreia Almeida ◽  
Marco Araújo ◽  
Ramon Novoa-Carballal ◽  
Fernanda Andrade ◽  
Hugo Gonçalves ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Hydrophobic Anticancer Drugs

Pluronic – Grafted Copolymers as Nanoplatforms for Effectively Delivering Hydrophobic Anticancer Drugs

2016 ◽  
Vol 8 (1) ◽  
pp. 1-11
Author(s):  
Ngoc Nguyen ◽  
T Nguyen ◽  
Phuong Do ◽  
T Nguyen ◽  
Van Nguyen ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Hydrophobic Anticancer Drugs

Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs

Small ◽  
2007 ◽  
Vol 3 (8) ◽  
pp. 1341-1346 ◽  
Author(s):  
Jie Lu ◽  
Monty Liong ◽  
Jeffrey I. Zink ◽  
Fuyuhiko Tamanoi
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Hydrophobic Anticancer Drugs

pH-sensitive nanogels based on Boltorn® H40 and poly(vinylpyridine) using mini-emulsion polymerization for delivery of hydrophobic anticancer drugs

Polymer ◽  
2014 ◽  
Vol 55 (16) ◽  
pp. 3579-3590 ◽  
Author(s):  
Hamid Sadeghi Abandansari ◽  
Mohammad Reza Nabid ◽  
Seyed Jamal Tabatabaei Rezaei ◽  
Hassan Niknejad
Keyword(s):  
Emulsion Polymerization ◽  
Anticancer Drugs ◽  
Ph Sensitive ◽  
Hydrophobic Anticancer Drugs

scholarly journals Development and Characterization of a Fucoidan-Based Drug Delivery System by Using Hydrophilic Anticancer Polysaccharides to Simultaneously Deliver Hydrophobic Anticancer Drugs

Biomolecules ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 970 ◽  
Author(s):  
Yen-Ho Lai ◽  
Chih-Sheng Chiang ◽  
Chin-Hao Hsu ◽  
Hung-Wei Cheng ◽  
San-Yuan Chen
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Drug Loading ◽  
Sulfated Polysaccharide ◽  
Plga Nanoparticles ◽  
Aqueous Environment ◽  
Sustained Drug Release ◽  
Hydrophobic Anticancer Drugs

Fucoidan, a natural sulfated polysaccharide, which can activate the immune response and lessen adverse effects, is expected to be an adjuvant agent in combination with chemotherapy. Using natural hydrophilic anticancer polysaccharides to simultaneously encapsulate hydrophobic anticancer drugs is feasible, and a reduced side effect can be achieved to amplify the therapeutic efficacy. In this study, a novel type of fucoidan-PLGA nanocarrier (FPN-DTX) was developed for the encapsulation of the hydrophobic anticancer drug, docetaxel (DTX), as a drug delivery system. From the comparison between FPN-DTX and the PLGA particles without fucoidan (PLGA-DTX), FPNs–DTX with fucoidan were highly stable with smaller sizes and dispersed well without aggregations in an aqueous environment. The drug loading and release can be further modified by modulating relative ratios of Fucoidan (Fu) to PLGA. The (FPN 3-DTX) nanoparticles with a 10:3 ratio of Fu:PLGA displayed uniform particle size with higher encapsulation efficiency than PLGA NPs and sustained drug release ability. The biocompatible fucoidan-PLGA nanoparticles displayed low cytotoxicity without drug loading after incubation with MDA-MB-231 triple-negative breast cancer cells. Despite lower cellular uptake than that of PLGA-DTX due to a higher degree of negative zeta potential and hydrophilicity, FPN 3-DTX effectively exerted better anticancer ability, so FPN 3-DTX can serve as a competent drug delivery system.

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