Chitosan Polymeric Micelles as Oral Delivery Platform of Hydrophobic Anticancer Drugs

2021 ◽  
pp. 251-270
Author(s):  
Andreia Almeida ◽  
Bruno Sarmento
Keyword(s):  
Anticancer Drugs ◽  
Oral Delivery ◽  
Polymeric Micelles ◽  
Delivery Platform ◽  
Hydrophobic Anticancer Drugs

scholarly journals Polymeric Micelles, a Promising Drug Delivery System to Enhance Bioavailability of Poorly Water-Soluble Drugs

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
Wei Xu ◽  
Peixue Ling ◽  
Tianmin Zhang
Keyword(s):  
Drug Delivery ◽  
Residence Time ◽  
Oral Delivery ◽  
Polymeric Micelles ◽  
Water Soluble ◽  
Gi Tract ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Accepted Form

Oral administration is the most commonly used and readily accepted form of drug delivery; however, it is find that many drugs are difficult to attain enough bioavailability when administered via this route. Polymeric micelles (PMs) can overcome some limitations of the oral delivery acting as carriers able to enhance drug absorption, by providing (1) protection of the loaded drug from the harsh environment of the GI tract, (2) release of the drug in a controlled manner at target sites, (3) prolongation of the residence time in the gut by mucoadhesion, and (4) inhibition of efflux pumps to improve the drug accumulation. To explain the mechanisms for enhancement of oral bioavailability, we discussed the special stability of PMs, the controlled release properties of pH-sensitive PMs, the prolongation of residence time with mucoadhesive PMs, and the P-gp inhibitors commonly used in PMs, respectively. The primary purpose of this paper is to illustrate the potential of PMs for delivery of poorly water-soluble drugs with bioavailability being well maintained.

scholarly journals A pillar[5]arene-based [2]rotaxane lights up mitochondria

2016 ◽  
Vol 7 (5) ◽  
pp. 3017-3024 ◽  
Author(s):  
Guocan Yu ◽  
Dan Wu ◽  
Yang Li ◽  
Zhihua Zhang ◽  
Li Shao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Targeted Drug Delivery ◽  
Therapeutic Agents ◽  
Delivery Platform ◽  
Targeted Drug ◽  
Mitochondria Targeting

Here we integrate diagnostic and therapeutic agents into a mitochondria-targeting [2]rotaxane, which can be utilized as a drug delivery platform to conjugate anticancer drugs to prepare prodrugs for efficient targeted drug delivery.

Polymeric micelles for targeted tumor therapy of platinum anticancer drugs

2017 ◽  
Vol 14 (12) ◽  
pp. 1423-1438 ◽  
Author(s):  
Yuki Mochida ◽  
Horacio Cabral ◽  
Kazunori Kataoka
Keyword(s):  
Anticancer Drugs ◽  
Polymeric Micelles ◽  
Tumor Therapy ◽  
Platinum Anticancer Drugs

Oral delivery of paclitaxel by polymeric micelles: A comparison of different block length on uptake, permeability and oral bioavailability

2019 ◽  
Vol 184 ◽  
pp. 110554 ◽  
Author(s):  
Lai Pan Sze ◽  
Ho Yin Li ◽  
Ka Lun Alan Lai ◽  
Shing Fung Chow ◽  
Qingqing Li ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
Oral Delivery ◽  
Polymeric Micelles ◽  
Block Length

Improving the oral delivery efficiency of anticancer drugs by chitosan coated polycaprolactone-grafted hyaluronic acid nanoparticles

2014 ◽  
Vol 2 (25) ◽  
pp. 4021-4033 ◽  
Author(s):  
Pingsheng Huang ◽  
Cuihong Yang ◽  
Jinjian Liu ◽  
Weiwei Wang ◽  
Shutao Guo ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Anticancer Drugs ◽  
Oral Delivery ◽  
Delivery Efficiency
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