Highly selective enrichment of phosphopeptides using aluminum silicate

2014 ◽  
Vol 6 (22) ◽  
pp. 9160-9167 ◽  
Author(s):  
Yüksel Güzel ◽  
Shah Hussain ◽  
Matthias Rainer ◽  
Günther K. Bonn
Keyword(s):  
Aluminum Silicate ◽  
Selective Enrichment ◽  
Novel Strategy ◽  
Mullite Powder ◽  
Aluminium Silicate

This study presents a novel strategy for highly selective enrichment of phosphopeptides using aluminium silicate (mullite) powder.

scholarly journals INFLUENCE OF FILM THICKNESS, TEMPERATURE AND INORGANIC FILLERS ON THE VOLUME ELECTRIC RESISTIVITY OF HEAT-CURING EPOXY VARNISH

1993 ◽  
Vol 1 (1) ◽  
pp. 97-105
Author(s):  
Minodora Leca ◽  
Ovidiu Segarceanu
Keyword(s):  
Experimental Data ◽  
Film Thickness ◽  
Material Constant ◽  
Regression Method ◽  
Electric Resistivity ◽  
Aluminum Silicate ◽  
Linear Regression Method ◽  
Heat Curing ◽  
Inorganic Fillers ◽  
Aluminium Silicate

The dependence of the volume electric resistivity of heat-during epoxy varnish on the film thickness, temperature, and nature of inorganic fillers for films obtained by spraying on steel supports cured for 30 minutes at l60 °C was determined. Film thicknesses ranged between 5 and 56 µm, temperature between 24 °C and l40 °C, and the fillers were rutile type titanium micronizes mica, colloidal aluminium oxide, and aluminium silicate. The experimental data, treated statistically by the Linear regression method, shows a linear dependence of the volume electric resistivity on the film thickness and a hyperbolic one on temperature. The highest volume electric resistivity was obtained for films containing titanium dioxide and the lowest one for those with aluminum silicate. The volume electric resistivity depends on film thickness for films deposited from the solution and can not be considered a material constant.

Research on Preparation of New Aluminum Silicate Fiber Adiabatic Paper

2013 ◽  
Vol 734-737 ◽  
pp. 2395-2398 ◽  
Author(s):  
Hui Rong Yang ◽  
Chuan Shan Zhao ◽  
Dong Mei Yu
Keyword(s):  
High Temperature ◽  
Paper Industry ◽  
Aluminum Silicate ◽  
Good Resistance ◽  
Plant Fiber ◽  
Plant Fibers ◽  
Special Paper ◽  
General Basis ◽  
The Difference ◽  
Aluminium Silicate

Aluminium silicate fiber is an excellent high-temperature material which is widely used in special paper industry in recent years. Due to its property of hardly interweave into the paper and the low strength of the single inorganic fibers paper, it is difficult to make a general basis weight paper. In response to these issues, the strength of the paper was improved by adding some plant fibers. This study takes advantage of good resistance to high temperature of inorganic adhesive and bonding capacity of organic intensifier. Meanwhile two inorganic adhesives (waterglass and ludox) and one organic adhesives carboxymethy starch (CMS) were used in the process of preparing the aluminium silicate paper. The physical properties and insulation properties of the paper which prepared from the difference conditions were studied. The experiment results showed that the adhesive of waterglass and ludox can improve the properties of resistant to high temperature. The adding dosages were 10% and 7.5ml, respectively. The best ratio of alumina silicate fiber to conifier fiber is 7 to 3.The using of CMS can decrease the amount of the plant fiber and its best usage is 10%.

The influence of heat treatment on the fiber/matrix interface in a SiC-reinforced glassceramic

1988 ◽  
Vol 46 ◽  
pp. 742-743
Author(s):  
E. Bischoff ◽  
O. Sbaizero
Keyword(s):  
Heat Treatment ◽  
Aluminum Silicate ◽  
Lithium Aluminum ◽  
Interfacial Region ◽  
Specimen Preparation ◽  
Crack Wake ◽  
Pull Out ◽  
Annealed Material ◽  
Ultrasonic Drilling ◽  
Fiber Matrix Interface

Fiber or whisker reinforced ceramics show improved toughness and strength. Bridging by intact fibers in the crack wake and fiber pull-out after failure contribute to the additional toughness. These processes are strongly influenced by the sliding and debonding resistance of the interfacial region. The present study examines the interface in a laminated 0/90 composite consisting of SiC (Nicalon) fibers in a lithium-aluminum-silicate (LAS) glass-ceramic matrix. The material shows systematic changes in sliding resistance upon heat treatment.As-processed samples were annealed in air at 800 °C for 2, 4, 8, 16 and 100 h, and for comparison, in helium at 800 °C for 4 h. TEM specimen preparation of as processed and annealed material was performed with special care by cutting along directions having the fibers normal and parallel to the section plane, ultrasonic drilling, dimpling to 100 pm and final ionthinning. The specimen were lightly coated with Carbon and examined in an analytical TEM operated at 200 kV.

Conditions for atomic imaging of mullite

1989 ◽  
Vol 47 ◽  
pp. 418-419
Author(s):  
T. A. Epicier ◽  
G. Thomas
Keyword(s):  
Oxygen Vacancies ◽  
High Resolution Electron Microscopy ◽  
Ceramic Materials ◽  
Work Conditions ◽  
Real Space ◽  
Potential Candidate ◽  
Silicate Mineral ◽  
Resolution Electron ◽  
The Subject ◽  
Aluminium Silicate

Mullite is an aluminium-silicate mineral of current interest since it is a potential candidate for high temperature applications in the ceramic materials field.In the present work, conditions under which the structure of mullite can be optimally imaged by means of High Resolution Electron Microscopy (HREM) have been investigated. Special reference is made to the Atomic Resolution Microscope at Berkeley which allows real space information up to ≈ 0.17 nm to be directly transferred; numerous multislice calculations (conducted with the CEMPAS programs) as well as extensive experimental through-focus series taken from a commercial “3:2” mullite at 800 kV clearly show that a resolution of at least 0.19 nm is required if one wants to get a straightforward confirmation of atomic models of mullite, which is known to undergo non-stoichiometry associated with the presence of oxygen vacancies.Indeed the composition of mullite ranges from approximatively 3Al2O3-2SiO2 (referred here as 3:2-mullite) to 2Al2O3-1SiO2, and its structure is still the subject of refinements (see, for example, refs. 4, 5, 6).

The Collaborative Network Approach: a model for advancing patient-centric research for Castleman disease and other rare diseases

2019 ◽  
Vol 3 (1) ◽  
pp. 97-105
Author(s):  
Mary Zuccato ◽  
Dustin Shilling ◽  
David C. Fajgenbaum
Keyword(s):  
Rare Diseases ◽  
Treatment Options ◽  
Castleman Disease ◽  
High Impact ◽  
Collaborative Network ◽  
Network Approach ◽  
Grant Applications ◽  
Research Questions ◽  
Novel Strategy ◽  
Patient Centric

Abstract There are ∼7000 rare diseases affecting 30 000 000 individuals in the U.S.A. 95% of these rare diseases do not have a single Food and Drug Administration-approved therapy. Relatively, limited progress has been made to develop new or repurpose existing therapies for these disorders, in part because traditional funding models are not as effective when applied to rare diseases. Due to the suboptimal research infrastructure and treatment options for Castleman disease, the Castleman Disease Collaborative Network (CDCN), founded in 2012, spearheaded a novel strategy for advancing biomedical research, the ‘Collaborative Network Approach’. At its heart, the Collaborative Network Approach leverages and integrates the entire community of stakeholders — patients, physicians and researchers — to identify and prioritize high-impact research questions. It then recruits the most qualified researchers to conduct these studies. In parallel, patients are empowered to fight back by supporting research through fundraising and providing their biospecimens and clinical data. This approach democratizes research, allowing the entire community to identify the most clinically relevant and pressing questions; any idea can be translated into a study rather than limiting research to the ideas proposed by researchers in grant applications. Preliminary results from the CDCN and other organizations that have followed its Collaborative Network Approach suggest that this model is generalizable across rare diseases.

Design and Optimization of a Novel Strategy for the Local Treatment of Helicobacter pylori Infections

2020 ◽  
Author(s):  
Taddese Mekonnen Ambay ◽  
Philipp Schick ◽  
Michael Grimm ◽  
Maximilian Sager ◽  
Felix Schneider ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Local Treatment ◽  
Design And Optimization ◽  
Novel Strategy

L cell stimulation: a novel strategy for oral peptide delivery in incretin-based diabetes treatment

2020 ◽  
Author(s):  
Ana Beloqui ◽  
Francesco Suriano ◽  
Matthias Hul ◽  
Yining Xu ◽  
Véronique Préat ◽  
...  
Keyword(s):  
Peptide Delivery ◽  
Diabetes Treatment ◽  
Cell Stimulation ◽  
Oral Peptide Delivery ◽  
L Cell ◽  
Novel Strategy

Melatonin: a novel strategy for prevention of obesity and fat accumulation in peripheral organs through the improvements of circadian rhythms and antioxidative capacity

2020 ◽  
Vol 3 (1) ◽  
pp. 58-76 ◽  
Author(s):  
Bohan Rong ◽  
Qiong Wu ◽  
Chao Sun
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Circadian Rhythms ◽  
Regulatory Mechanisms ◽  
Antioxidative Capacity ◽  
Unicellular Alga ◽  
Peripheral Tissues ◽  
Peripheral Organs ◽  
Regulatory Effects ◽  
Novel Strategy

Melatonin is a well-known molecule for its involvement in circadian rhythm regulation and its contribution to protection against oxidative stress in organisms including unicellular alga, animals and plants. Currently, the bio-regulatory effects of melatonin on the physiology of various peripheral tissues have drawn a great attention of scientists. Although melatonin was previously defined as a neurohormone secreted from pineal gland, recently it has been identified that virtually, every cell has the capacity to synthesize melatonin and the locally generated melatonin has multiple pathophysiological functions, including regulations of obesity and metabolic syndromes. Herein, we focus on the effects of melatonin on fat deposition in various peripheral organs/tissues. The two important regulatory mechanisms related to the topic, i.e., the improvements of circadian rhythms and antioxidative capacity will be thoroughly discussed since they are linked to several biomarkers involved in obesity and energy imbalance, including metabolism and immunity. Furthermore, several other functions of melatonin which may serve to prevent or promote obesity and energy dysmetabolism-induced pathological states are also addressed. The organs of special interest include liver, pancreas, skeletal muscle, adipose tissue and the gut microbiota.

Unravelling a microbial synergy to boost caproate production via carboxylates chain elongation with ethanol

2019 ◽  
Vol 26 (2) ◽  
pp. 63-71
Author(s):  
Ling Leng ◽  
Ying Wang ◽  
Peixian Yang ◽  
Takashi Narihiro ◽  
Masaru Konishi Nobu ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Volatile Fatty Acids ◽  
Microbial Consortia ◽  
Chain Elongation ◽  
Desulfovibrio Vulgaris ◽  
Rrna Gene ◽  
Selective Enrichment ◽  
Microbial Network ◽  
Cost Efficient ◽  
Rrna Gene Sequencing

Chain elongation of volatile fatty acids for medium chain fatty acids production (e.g. caproate) is an attractive approach to treat wastewater anaerobically and recover resource simultaneously. Undefined microbial consortia can be tailored to achieve chain elongation process with selective enrichment from anaerobic digestion sludge, which has advantages over pure culture approach for cost-efficient application. Whilst the metabolic pathway of the dominant caproate producer, Clostridium kluyveri, has been annotated, the role of other coexisting abundant microbiomes remained unclear. To this end, an ethanol-acetate fermentation inoculated with fresh digestion sludge at optimal conditions was conducted. Also, physiological study, thermodynamics and 16 S rRNA gene sequencing to elucidate the biological process by linking the system performance and dominant microbiomes were integrated. Results revealed a possible synergistic network in which C. kluyveri and three co-dominant species, Desulfovibrio vulgaris, Fusobacterium varium and Acetoanaerobium sticklandii coexisted. D. vulgaris and A. sticklandii (F. varium) were likely to boost the carboxylates chain elongation by stimulating ethanol oxidation and butyrate production through a syntrophic partnership with hydrogen (H2) serving as an electron messenger. This study unveils a synergistic microbial network to boost caproate production in mixed culture carboxylates chain elongation.

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