Determination methods for the anticancer drug dicycloplatin, a supramolecule assembled through hydrogen bonding

The Analyst ◽  
2015 ◽  
Vol 140 (8) ◽  
pp. 2704-2712 ◽  
Author(s):  
Xuqing Yang ◽  
Jianwei Zheng ◽  
Qinghua Song ◽  
Fang Xie ◽  
Jijun Tang ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Anticancer Drug ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Determination Methods ◽  
New Generation

Dicycloplatin is a new generation supramolecular platinum-containing anti-cancer drug.

Loading of an anti-cancer drug onto graphene oxide and subsequent release to DNA/RNA: a direct optical detection

Nanoscale ◽  
2014 ◽  
Vol 6 (5) ◽  
pp. 2937-2944 ◽  
Author(s):  
Raj Kumar Koninti ◽  
Abhigyan Sengupta ◽  
Krishna Gavvala ◽  
Nirmalya Ballav ◽  
Partha Hazra
Keyword(s):  
Graphene Oxide ◽  
Anticancer Drug ◽  
Optical Detection ◽  
Fluorescence Property ◽  
Cancer Drug ◽  
Dual Fluorescence ◽  
Fluorescence Switch ◽  
Anti Cancer ◽  
Efficient Loading

Sensing of bio-molecules using the fluorescence-switch/dual fluorescence property of an eminent anticancer drug, ellipticine, has been explored to directly monitor its efficient loading onto graphene oxide and subsequent release to biomolecules like DNA/RNA.

Preparation of Chitosan Antioxidant Nanoparticles as Drug Delivery System for Enhancing of Anti-Cancer Drug

2018 ◽  
Vol 759 ◽  
pp. 92-97 ◽  
Author(s):  
Hassan M. Ibrahim ◽  
Omar A. Farid ◽  
Amany Samir ◽  
Rehab M. Mosaad
Keyword(s):  
Anticancer Drug ◽  
Biochemical Parameters ◽  
Tumor Volume ◽  
Chitosan Nanoparticles ◽  
Response To Treatment ◽  
Cancer Drug ◽  
Clinical Use ◽  
Transmission Electron ◽  
Anti Cancer ◽  
Eac Cells

Chemotherapy is a major therapeutic approach for the treatment of localized and metastasized cancers. Although Doxorubicin (DOX) possesses abroad spectrum of anticancer activity, its clinical use is limited because of it cause heart failure. Chitosan nanoparticles was prepared by using ionic gelation method. These nanoaparticles were used as polyload of anticancer DOX to form safer and non-toxic anticancer drug. infrared spectroscopy (FTIR) and transmission electron microscope (TEM) were used to characterize the prepared nanoparticles. The cancer animals’ experiments using Ehrlich static cancer, (EAC) cells using six groups of experimental animals were performed to evaluate the efficiency of Doxorubicin and Doxorubicin loaded chitosan nanoparticles as anticancer drug especially from its toxicity towards heart. Tumor volume was calculated as to monitor the response to treatment. Cytotoxicity of Doxorubicin and Doxorubicin loaded chitosan nanoparticles were evaluated. Biochemical parameters were be estimated to illustrate the cytotoxicity of these drugs on heart.

A 195Pt and 15N N.M.R. study of the anticancer drug, cis-diammine-dichloroplatinum(II), and its hydrolysis and oligomerization products

1981 ◽  
Vol 34 (3) ◽  
pp. 659 ◽  
Author(s):  
CJ Boreham ◽  
JA Broomhead ◽  
DP Fairlie
Keyword(s):  
Sodium Chloride ◽  
Aqueous Solutions ◽  
Anticancer Drug ◽  
Cancer Drug ◽  
Anti Cancer

195Pt and 15N n.m.r, spectra for aqueous solutions of the anti-cancer drug cis-diamminedichloroplatinum(II) and its hydrolysis and oligomerization products are reported. In the blood substituteHanks medium, conversion of cis-[Pt(15NH3)2(H20)2](NO3)2 into cis[PtCl2(15NH3)2], cis-[PtCl(H20)(15NH3)2]+,[Pt(15NH3)2OH]33+ and [Pt(15NH3)2OH]22+ has been observed, the reaction taking several hours at 30�C. In 0.15 M sodium chloride, both [Pt(NH3)2OH]33+ and[Pt(NH3)2OH]22+ are converted overnight into cis-[PtCl(H2O)(NH3)2]+. The infrared bands at 546 and 522 cm-1 in [Pt(NH3)2OH]2SO4 and at 520 cm-1 in [Pt(NH3)2OH]2(SO4)3 have been reassigned to Pt-N modes.

scholarly journals Current progress and future perspectives in the development of anti-polo-like kinase 1 therapeutic agents

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1024 ◽  
Author(s):  
Jung-Eun Park ◽  
David Hymel ◽  
Terrence R. Burke, Jr. ◽  
Kyung S. Lee
Keyword(s):  
Side Effects ◽  
Cancer Therapeutics ◽  
Current Status ◽  
Cancer Drug ◽  
Mitotic Progression ◽  
Cancer Drug Discovery ◽  
Anti Cancer ◽  
Tumor Specificity ◽  
The Subject ◽  
New Generation

Although significant levels of side effects are often associated with their use, microtubule-directed agents that primarily target fast-growing mitotic cells have been considered to be some of the most effective anti-cancer therapeutics. With the hope of developing new-generation anti-mitotic agents with reduced side effects and enhanced tumor specificity, researchers have targeted various proteins whose functions are critically required for mitotic progression. As one of the highly attractive mitotic targets, polo-like kinase 1 (Plk1) has been the subject of an extensive effort for anti-cancer drug discovery. To date, a variety of anti-Plk1 agents have been developed, and several of them are presently in clinical trials. Here, we will discuss the current status of generating anti-Plk1 agents as well as future strategies for designing and developing more efficacious anti-Plk1 therapeutics.

scholarly journals Gemcitabine-incorporated polyurethane films for controlled release of an anticancer drug

2019 ◽  
Vol 23 (1) ◽  
Author(s):  
Seong Hoon Choi ◽  
Il-Hoon Cho ◽  
Sangsoo Park
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Plasma Treatment ◽  
Anticancer Drug ◽  
Film Surface ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Polyurethane Film ◽  
Silicone Film ◽  
Scanning Electron

Abstract Background Local delivery of anti-cancer drugs through a stent is a very promising and anticipated treatment modality for patients who have obstructions in their gastrointestinal tract with malignant tumors. Anticancer drug release via stents, however, needs to be optimized with respect to drug delivery behavior for the stents to be effective for prolonged containment of tumor proliferation and stent re-obstruction. Local stent-based drug delivery has been tested using an effective anti-cancer drug, gemcitabine, but the release from the stent-coated polyurethane films is often too fast and the drug is depleted from the coated film virtually in a day. Methods To moderate the drug release from a polyurethane film, a gemcitabine-incorporated polyurethane film was enveloped with a pure polyurethane film, with no drug loading, and with a silicone film by solution casting after activation of the silicone film surface with plasma treatment. Results The pure polyurethane barrier film was effective; the interface of the two were indistinguishable on scanning electron microscopy, and the initial burst, i.e., the cumulative release in a day, decreased from 90 to 26%. The silicone film barrier, on the other hand, was defective as voids were seen using a scanning electron microscope, and micro-separation of the two layers was observed after the film was immersed in phosphate-buffered saline for 1 day during the in vitro drug release study. Conclusions Enveloping a gemcitabine-releasing polyurethane film with a homo-polymer barrier film was quite effective for moderating the initial burst of gemcitabine, thus, prolonging the release time of the drug. Enveloping the polyurethane film with a silicone film was also possible after plasma treatment of the silicone film surface, but the two films eventually separated in the aqueous environment. More studies are needed to tune the drug release behavior of gemcitabine from the stent covering film before attempting a clinical application of an anti-cancer drug releasing stent.

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052053001-8
Author(s):  
K. Murai ◽  
H. Yamazaki ◽  
K. Nakagawa ◽  
R. Kawai ◽  
T. Kamataki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cytochrome P450 2A6

Psychogenic Mass Syndrome in Anti-Cancer Drug Exposure

2010 ◽  
Author(s):  
N. Magnavita ◽  
I. lavicoli ◽  
V. Leso ◽  
A. Bergamaschi
Keyword(s):  
Drug Exposure ◽  
Cancer Drug ◽  
Anti Cancer
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