Loading of an anti-cancer drug onto graphene oxide and subsequent release to DNA/RNA: a direct optical detection

Nanoscale ◽  
2014 ◽  
Vol 6 (5) ◽  
pp. 2937-2944 ◽  
Author(s):  
Raj Kumar Koninti ◽  
Abhigyan Sengupta ◽  
Krishna Gavvala ◽  
Nirmalya Ballav ◽  
Partha Hazra
Keyword(s):  
Graphene Oxide ◽  
Anticancer Drug ◽  
Optical Detection ◽  
Fluorescence Property ◽  
Cancer Drug ◽  
Dual Fluorescence ◽  
Fluorescence Switch ◽  
Anti Cancer ◽  
Efficient Loading

Sensing of bio-molecules using the fluorescence-switch/dual fluorescence property of an eminent anticancer drug, ellipticine, has been explored to directly monitor its efficient loading onto graphene oxide and subsequent release to biomolecules like DNA/RNA.

Development of A Novel System Based on Green Magnetic / Graphene Oxide / Chitosan /Allium Sativum / Quercus / Nanocomposite for Targeted Release of Doxorubicin Anti-Cancer Drug

2020 ◽  
Vol 20 (9) ◽  
pp. 1094-1104 ◽  
Author(s):  
Omid Arjmand ◽  
Mehdi Ardjmand ◽  
Ali M. Amani ◽  
Mohmmad H. Eikani
Keyword(s):  
Graphene Oxide ◽  
Allium Sativum ◽  
Cytotoxicity Assay ◽  
Targeted Treatment ◽  
Cancer Drug ◽  
Magnetic Graphene Oxide ◽  
Magnetic Graphene ◽  
Anti Cancer ◽  
Cancerous Cells ◽  
Targeted Release

Background: Doxorubicin, as a strong anti-cancer agent for clinical treatment of various cancer types along with other drugs, is widely utilized. Due to the physiology of the human body and cancerous tissues, the applicability of doxorubicin is still limited and the targeted treatment of the different types of cancers is considered. Also, the side effects of the conventional forms of chemotherapy medicines, damaging and stressing the normal cells are considerable. Objective: This study introduces a novel and effective system for the targeted release of doxorubicin by successfully fabricating the green magnetic graphene oxide, chitosan, allium sativum, and quercus nanocomposite. Methods: The in vitro release of doxorubicin loaded on the nanocomposite was evaluated and investigated at pH 7.4 and 6.5, respectively. The drug diffusivity in the plasma environment was assessed for a more accurate analysis of the drug diffusion process. The nanocomposite loaded drug release mechanism and kinetics, as well as cytotoxicity assay was investigated. Results: The efficiency of the drug encapsulation was significantly enhanced using natural extract ingredients and consequently, the efficacy of the targeted treatment of cancerous tissues was improved. The developed nanocomposite provided a controlled release of doxorubicin in similar acidic conditions of the normal and cancerous cells and affirming that the fabricated system is thoroughly pH-dependent. Conclusion: The cytotoxicity assay confirmed that the fabricated nanocomposite at a high growth rate of cancerous cells has an anticancer property and acts as a toxic agent against tumor cells, suggesting that in conjunction with doxorubicin, it can be highly improved for killing cancerous cells.

scholarly journals A facile graphene oxide based sensor for electrochemical detection of prostate anti-cancer (anti-testosterone) drug flutamide in biological samples

RSC Advances ◽  
2017 ◽  
Vol 7 (41) ◽  
pp. 25702-25709 ◽  
Author(s):  
R. Karthik ◽  
Mani Govindasamy ◽  
Shen-Ming Chen ◽  
Tse-Wei Chen ◽  
J. Vinoth kumar ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Electrochemical Sensor ◽  
Electrochemical Detection ◽  
Glassy Carbon ◽  
Biological Samples ◽  
Cancer Drug ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Anti Cancer

An electrochemical sensor based on graphene oxide modified glassy carbon electrode for the determination of anti-cancer drug flutamide.

Preparation of Chitosan Antioxidant Nanoparticles as Drug Delivery System for Enhancing of Anti-Cancer Drug

2018 ◽  
Vol 759 ◽  
pp. 92-97 ◽  
Author(s):  
Hassan M. Ibrahim ◽  
Omar A. Farid ◽  
Amany Samir ◽  
Rehab M. Mosaad
Keyword(s):  
Anticancer Drug ◽  
Biochemical Parameters ◽  
Tumor Volume ◽  
Chitosan Nanoparticles ◽  
Response To Treatment ◽  
Cancer Drug ◽  
Clinical Use ◽  
Transmission Electron ◽  
Anti Cancer ◽  
Eac Cells

Chemotherapy is a major therapeutic approach for the treatment of localized and metastasized cancers. Although Doxorubicin (DOX) possesses abroad spectrum of anticancer activity, its clinical use is limited because of it cause heart failure. Chitosan nanoparticles was prepared by using ionic gelation method. These nanoaparticles were used as polyload of anticancer DOX to form safer and non-toxic anticancer drug. infrared spectroscopy (FTIR) and transmission electron microscope (TEM) were used to characterize the prepared nanoparticles. The cancer animals’ experiments using Ehrlich static cancer, (EAC) cells using six groups of experimental animals were performed to evaluate the efficiency of Doxorubicin and Doxorubicin loaded chitosan nanoparticles as anticancer drug especially from its toxicity towards heart. Tumor volume was calculated as to monitor the response to treatment. Cytotoxicity of Doxorubicin and Doxorubicin loaded chitosan nanoparticles were evaluated. Biochemical parameters were be estimated to illustrate the cytotoxicity of these drugs on heart.

Non-covalent modification of graphene oxide nanocomposites with chitosan/dextran and its application in drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (11) ◽  
pp. 9328-9337 ◽  
Author(s):  
Meng Xie ◽  
Hailin Lei ◽  
Yufeng Zhang ◽  
Yuanguo Xu ◽  
Song Shen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Self Assembly ◽  
Covalent Modification ◽  
Cancer Drug ◽  
Graphene Oxide Nanosheets ◽  
Drug Delivery Application ◽  
Anti Cancer ◽  
Assembly Technique ◽  
Cancer Drug Delivery

Graphene oxide nanosheets non-covalent functionalized with chitosan/dextran was successfully developed via LbL self-assembly technique for anti-cancer drug delivery application.

A 195Pt and 15N N.M.R. study of the anticancer drug, cis-diammine-dichloroplatinum(II), and its hydrolysis and oligomerization products

1981 ◽  
Vol 34 (3) ◽  
pp. 659 ◽  
Author(s):  
CJ Boreham ◽  
JA Broomhead ◽  
DP Fairlie
Keyword(s):  
Sodium Chloride ◽  
Aqueous Solutions ◽  
Anticancer Drug ◽  
Cancer Drug ◽  
Anti Cancer

195Pt and 15N n.m.r, spectra for aqueous solutions of the anti-cancer drug cis-diamminedichloroplatinum(II) and its hydrolysis and oligomerization products are reported. In the blood substituteHanks medium, conversion of cis-[Pt(15NH3)2(H20)2](NO3)2 into cis[PtCl2(15NH3)2], cis-[PtCl(H20)(15NH3)2]+,[Pt(15NH3)2OH]33+ and [Pt(15NH3)2OH]22+ has been observed, the reaction taking several hours at 30�C. In 0.15 M sodium chloride, both [Pt(NH3)2OH]33+ and[Pt(NH3)2OH]22+ are converted overnight into cis-[PtCl(H2O)(NH3)2]+. The infrared bands at 546 and 522 cm-1 in [Pt(NH3)2OH]2SO4 and at 520 cm-1 in [Pt(NH3)2OH]2(SO4)3 have been reassigned to Pt-N modes.

Highly sensitive detection of anti-cancer drug based on bimetallic reduced graphene oxide nanocomposite

Chemosphere ◽  
2021 ◽  
pp. 132281
Author(s):  
Bathinapatla Sravani ◽  
S. Kiranmai ◽  
G. Rajasekhar Reddy ◽  
Jong Pil Park ◽  
Y. Veera Manohara Reddy ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Sensitive Detection ◽  
Cancer Drug ◽  
Reduced Graphene ◽  
Highly Sensitive ◽  
Anti Cancer ◽  
Highly Sensitive Detection

Determination methods for the anticancer drug dicycloplatin, a supramolecule assembled through hydrogen bonding

The Analyst ◽  
2015 ◽  
Vol 140 (8) ◽  
pp. 2704-2712 ◽  
Author(s):  
Xuqing Yang ◽  
Jianwei Zheng ◽  
Qinghua Song ◽  
Fang Xie ◽  
Jijun Tang ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Anticancer Drug ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Determination Methods ◽  
New Generation

Dicycloplatin is a new generation supramolecular platinum-containing anti-cancer drug.

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