Targeting of parallel c-myc G-quadruplex by dimeric cyanine dye supramolecular assembly: dependence on the linker length

The Analyst ◽  
2015 ◽  
Vol 140 (5) ◽  
pp. 1637-1646 ◽  
Author(s):  
Lijia Yu ◽  
Qianfan Yang ◽  
Junfeng Xiang ◽  
Hongxia Sun ◽  
Lixia Wang ◽  
...  
Keyword(s):  
Supramolecular Assembly ◽  
Cyanine Dyes ◽  
Cyanine Dye ◽  
Linker Length ◽  
G Quadruplex

The recognizing ability of parallel c-myc G-quadruplex by dimeric cyanine dyes depends on their linker length.

scholarly journals Disassembly of Dimeric Cyanine Dye Supramolecular Assembly by Tetramolecular G-quadruplex Dependence on Linker Length and Layers of G-quartet

Molecules ◽  
2019 ◽  
Vol 24 (10) ◽  
pp. 2015 ◽  
Author(s):  
Lijia Yu ◽  
Yansong Zhang ◽  
Chunguang Ding ◽  
Xiaodong Shi
Keyword(s):  
Supramolecular Assembly ◽  
Cyanine Dyes ◽  
Binding Mode ◽  
Cyanine Dye ◽  
Linker Length ◽  
Disassembly Process ◽  
1H Nmr Titration ◽  
Repeat Units ◽  
G Quadruplex ◽  
Photochemical Properties

Cyanine dyes have been widely applied in various biological systems owing to their specific photochemical properties. Assembly and disassembly process of cyanine dyes were constructed and regulated by special biomolecules. In this paper, dimeric cyanine dyes with different repeat units (oligo-oxyethylene) in linker (TC-Pn) (n = 3–6) were found to form H-aggregates or mixture aggregates in PBS. These aggregates could be disassembled into dimer and/or monomer by (TGnT) tetramolecular G-quadruplexes (n = 3–6, 8), which were affected by the linker length of dimeric cyanine dyes and layers of G-quartets. The 1H-NMR titration results suggest that the binding mode of dimeric cyanine dye with TGnT might be on both ends—stacking like a clip. This binding mode could clearly explain that matching structures between dimeric cyanine dyes and TGnT quadruplexes could regulate the disassembly properties of aggregates. These results could provide clues for the development of highly specific G-quadruplex probes.

scholarly journals Albumin-chaperoned cyanine dye yields superbright NIR-II fluorophore with enhanced pharmacokinetics

2019 ◽  
Vol 5 (9) ◽  
pp. eaaw0672 ◽  
Author(s):  
Rui Tian ◽  
Qiao Zeng ◽  
Shoujun Zhu ◽  
Joseph Lau ◽  
Swati Chandra ◽  
...  
Keyword(s):  
High Performance ◽  
Tumor Imaging ◽  
Supramolecular Assembly ◽  
Cyanine Dyes ◽  
Circulation Time ◽  
Cyanine Dye ◽  
Tissue Imaging ◽  
Quantum Yields ◽  
Scattering Coefficients ◽  
Targeting Ability

NIR-II fluorescence imaging greatly reduces scattering coefficients for nearly all tissue types at long wavelengths, benefiting deep tissue imaging. However, most of the NIR-II fluorophores suffer from low quantum yields and/or short circulation time that limit the quality of NIR-II imaging. Here, we engineered a supramolecular assembly of protein complex with lodged cyanine dyes to produce a brilliant NIR-II fluorophore, providing a NIR-II quantum yield of 21.2% with prolonged circulation time. Computational modeling revealed the mechanism for fluorescence enhancement and identified key parameters governing albumin complex for NIR-II fluorophores. Our complex afforded high-resolution microvessel imaging, with a 3-hour imaging window compared to 2 min for free dye alone. Furthermore, the complexation strategy was applied to an antibody-derived assembly, offering high-contrast tumor imaging without affecting the targeting ability of the antibody. This study provides a facile strategy for producing high-performance NIR-II fluorophores by chaperoning cyanine dyes with functional proteins.

A cyanine dye supramolecular FRET switch driven by G-quadruplex to monitor mitophagy

2021 ◽  
pp. 109429
Author(s):  
Xiaomeng Guo ◽  
Dawei Yang ◽  
Ranran Sun ◽  
Qian Li ◽  
Hongyan Du ◽  
...  
Keyword(s):  
Cyanine Dye ◽  
G Quadruplex

The development of a light-up red-emitting fluorescent probe based on a G-quadruplex specific cyanine dye

RSC Advances ◽  
2016 ◽  
Vol 6 (74) ◽  
pp. 70117-70123 ◽  
Author(s):  
Xing Chen ◽  
Jine Wang ◽  
Guimei Jiang ◽  
Guangyue Zu ◽  
Min Liu ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Cyanine Dye ◽  
Polymethine Chain ◽  
G Quadruplex

Cyanine dye-dimethylindole red containing an anionic propylsulfonate substituent and an extending polymethine chain was found to behave as a highly specific red-emitting G-quadruplex probe, especially for parallel G-quadruplex c-myc.

Tuneable DNA-based asymmetric catalysis using a G-quadruplex supramolecular assembly

2010 ◽  
Vol 46 (24) ◽  
pp. 4309 ◽  
Author(s):  
Stephen Roe ◽  
Dougal J. Ritson ◽  
Tom Garner ◽  
Mark Searle ◽  
John E. Moses
Keyword(s):  
Asymmetric Catalysis ◽  
Supramolecular Assembly ◽  
G Quadruplex

Reversible regulation of the supramolecular chirality of a cyanine dye by using the G-quadruplex structure as a template

2016 ◽  
Vol 52 (45) ◽  
pp. 7302-7305 ◽  
Author(s):  
Yunhua Shi ◽  
Hongxia Sun ◽  
Junfeng Xiang ◽  
Hongbo Chen ◽  
Suge Zhang ◽  
...  
Keyword(s):  
Cyanine Dye ◽  
Quadruplex Structure ◽  
Supramolecular Chirality ◽  
G Quadruplex ◽  
Multiple Cycle ◽  
Cycle Regulation

Multiple cycle regulation of the supramolecular chirality of a cyanine dye has been successfully achieved by using DNA G-quadruplexes as templates, which is easily controllable by repeated addition of Ag+ and cysteine (Cys).

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