Characterization of the herb-derived components in rats following oral administration of Carthamus tinctorius extract by extracting diagnostic fragment ions (DFIs) in the MSn chromatograms

The Analyst ◽  
2014 ◽  
Vol 139 (24) ◽  
pp. 6474-6485 ◽  
Author(s):  
Jin-Feng Chen ◽  
Yue-Lin Song ◽  
Xiao-Yu Guo ◽  
Peng-Fei Tu ◽  
Yong Jiang
Keyword(s):  
Oral Administration ◽  
Carthamus Tinctorius ◽  
Fragment Ions ◽  
Diagnostic Fragment ◽  
Tof Ms

An E(DFI)MSnCs-based strategy was proposed to rapidly detect and identify the in vivo components derived from the extract of Carthamus tinctorius using LC-IT-TOF-MSn.

scholarly journals A novel strategy for the characterization of glaucocalyxin A metabolites in vivo and in vitro by UHPLC-Q-TOF-MS based on DDA and DIA data acquisitions

RSC Advances ◽  
2020 ◽  
Vol 10 (18) ◽  
pp. 10431-10446
Author(s):  
Wenjing Sun ◽  
Yiran Jin ◽  
Shuai Guan ◽  
Mengxin Yang ◽  
Miaoting Zhang ◽  
...  
Keyword(s):  
Process Flow ◽  
Experimental Process ◽  
Novel Strategy ◽  
Tof Ms

The experimental process flow.

Comprehensive characterization of the in vitro and in vivo metabolites of limonin in human samples using LC-Q-TOF/MS

2017 ◽  
Vol 1068-1069 ◽  
pp. 226-232 ◽  
Author(s):  
Shijia Liu ◽  
Peidong Chen ◽  
Nongshan Zhang ◽  
Luning Sun ◽  
Guoliang Dai ◽  
...  
Keyword(s):  
Human Samples ◽  
Comprehensive Characterization ◽  
Tof Ms

UHPLC-Q-TOF-MS/MS based screening and identification of the metabolites in vivo after oral administration of betulin

Fitoterapia ◽  
2018 ◽  
Vol 127 ◽  
pp. 29-41 ◽  
Author(s):  
Wendan Zhang ◽  
Honghong Jiang ◽  
Miaomiao Jin ◽  
Qiao Wang ◽  
Qian Sun ◽  
...  
Keyword(s):  
Oral Administration ◽  
Screening And Identification ◽  
Tof Ms

scholarly journals Comprehensive characterization of the chemical constituents in Yiganmingmu oral liquid and the absorbed prototypes in cynomolgus monkey plasma after oral administration by UPLC-Q-TOF-MS based on the self built components database

2021 ◽  
Author(s):  
wei wei ◽  
Siwei Li ◽  
Linyou Cheng ◽  
Erwei Hao ◽  
Xiaotao Hou ◽  
...  
Keyword(s):  
Oral Administration ◽  
Phenolic Acids ◽  
Cynomolgus Monkey ◽  
Chemical Constituents ◽  
Herbal Medicines ◽  
The Self ◽  
Triterpenoid Saponins ◽  
Oral Liquid ◽  
Tof Ms

Abstract Background: Yiganmingmu oral liquid (YGMM), a well known over-the-counter (OTC) drug in China, is composed of 12 types of valuable herbal medicines and has been widely used in clinical for the treatment of soreness and weakness of waist and knees, dizziness, memory loss, and fatigue. However, the chemical compositions of YGMM and its absorbed compounds in plasma remain unclear. Methods: Since chemical investigation is the first important step to reveal effects and action mechanisms of traditional Chinese medicine (TCM), in this study, based on the self built components database, systematic characterization of the chemical profile of YGMM in vivo was carried out by using a reliable UPLC-Q-TOF-MS method. Moreover, to obtain better understanding of the absorbed prototypes in plasma, serum pharmacochemistry analysis of YGMM after oral administration was conducted by using cynomolgus monkeys as animal model. Results: A total of 667 constituents from the 12 single herbal medicines were collected in the self built components database by searching the reported literatures, and 415 of them were initially screened as candidate compounds in YGMM by comparison of their experimental accurate mass measurements with those theoretical values. After that, 117 compounds including 17 phenolic acids, 25 flavonoids, 4 alkaloids, 10 phthalides, 5 monoterpenes, 8 triterpenoid saponins, 9 anthraquinones, and 39 other compounds, were unambiguously identified or tentatively characterized by analysing their MS/MS fragmentation patterns, and also by comparison with reference standards and those data reported in the literatures. 61 prototypes absorbed in plasma of cynomolgus monkey, including 13 phenolic acids, 21 flavonoids, 8 phthalides, 3 monoterpenes, 4 triterpenoid saponins, and 12 other compounds were tentatively assigned by serum pharmacochemistry analysis after oral administration. Conclusion: It was the first comprehensive analysis of chemical constituents of YGMM and prototypes in plasma, and the data analysis strategy developed in this study showed high efficiency in the structural elucidations. The results might provide scientific evidence for further research on material basis of YGMM.

Preparation and in-vitro/in-vivo characterization of trans-resveratrol nanocrystals for oral administration

2017 ◽  
Vol 7 (3) ◽  
pp. 395-407 ◽  
Author(s):  
Sandeep K. Singh ◽  
Vishal Makadia ◽  
Shweta Sharma ◽  
Mamunur Rashid ◽  
Sudhir Shahi ◽  
...  
Keyword(s):  
Oral Administration ◽  
In Vivo Characterization
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