Systematic screening and characterization of absorbed constituents and in vivo metabolites in rats after oral administration of Rhizoma coptidis using UPLC‐Q‐TOF/MS

2020 ◽  
Vol 34 (10) ◽  
Author(s):  
Xinchi Feng ◽  
Kun Wang ◽  
Xintong Hu ◽  
Liwei Chai ◽  
Shijie Cao ◽  
...  
Keyword(s):  
Oral Administration ◽  
Systematic Screening ◽  
Rhizoma Coptidis ◽  
Tof Ms

Characterization of the herb-derived components in rats following oral administration of Carthamus tinctorius extract by extracting diagnostic fragment ions (DFIs) in the MSn chromatograms

The Analyst ◽  
2014 ◽  
Vol 139 (24) ◽  
pp. 6474-6485 ◽  
Author(s):  
Jin-Feng Chen ◽  
Yue-Lin Song ◽  
Xiao-Yu Guo ◽  
Peng-Fei Tu ◽  
Yong Jiang
Keyword(s):  
Oral Administration ◽  
Carthamus Tinctorius ◽  
Fragment Ions ◽  
Diagnostic Fragment ◽  
Tof Ms

An E(DFI)MSnCs-based strategy was proposed to rapidly detect and identify the in vivo components derived from the extract of Carthamus tinctorius using LC-IT-TOF-MSn.

scholarly journals A novel strategy for the characterization of glaucocalyxin A metabolites in vivo and in vitro by UHPLC-Q-TOF-MS based on DDA and DIA data acquisitions

RSC Advances ◽  
2020 ◽  
Vol 10 (18) ◽  
pp. 10431-10446
Author(s):  
Wenjing Sun ◽  
Yiran Jin ◽  
Shuai Guan ◽  
Mengxin Yang ◽  
Miaoting Zhang ◽  
...  
Keyword(s):  
Process Flow ◽  
Experimental Process ◽  
Novel Strategy ◽  
Tof Ms

The experimental process flow.

scholarly journals Systematic screening and characterization of cardamonin metabolites using UHPLC-Q-Exactive Orbitrap MS after oral administration to rats

2020 ◽  
Vol 13 (12) ◽  
pp. 8768-8782
Author(s):  
Fan Dong ◽  
Shaoping Wang ◽  
Ailin Yang ◽  
Qiyan Li ◽  
Yuqi Wang ◽  
...  
Keyword(s):  
Oral Administration ◽  
Systematic Screening ◽  
Q Exactive ◽  
Orbitrap Ms

Comprehensive characterization of the in vitro and in vivo metabolites of limonin in human samples using LC-Q-TOF/MS

2017 ◽  
Vol 1068-1069 ◽  
pp. 226-232 ◽  
Author(s):  
Shijia Liu ◽  
Peidong Chen ◽  
Nongshan Zhang ◽  
Luning Sun ◽  
Guoliang Dai ◽  
...  
Keyword(s):  
Human Samples ◽  
Comprehensive Characterization ◽  
Tof Ms

Pharmacokinetics of Five Alkaloids and their Metabolites in Normal and Diabetic Rats after Oral Administration of Rhizoma coptidis

Planta Medica ◽  
2021 ◽  
Author(s):  
Xinchi Feng ◽  
Kun Wang ◽  
Shijie Cao ◽  
Liqin Ding ◽  
Feng Qiu
Keyword(s):  
Oral Administration ◽  
Diabetic Rats ◽  
Pharmacokinetic Studies ◽  
Rhizoma Coptidis ◽  
Material Basis ◽  
Diabetic Model ◽  
Long Time ◽  
Treatment Of Diabetes ◽  
Phase Ii Metabolites

AbstractRhizoma coptidis has been clinically used for a long time for the treatment of various diseases in China, such as hypertension, diabetes, and inflammation. Previous studies have shown that alkaloid components of Rhizoma coptidis extract could be extensively metabolized and the metabolites were also considered to be the therapeutic material basis. However, until now, pharmacokinetic studies of the in vivo metabolites have not been revealed yet. The aim of the present study was to characterize the pharmacokinetics and excretions of five main alkaloids (berberine, jatrorrhizine, palmatine, epiberberine, and coptisine) and their seven metabolites (berberrubine, demethyleneberberine, jatrorrhizine-3-O-β-D-glucuronide, thalifendine-10-O-β-D-glucuronide, berberrubine-9-O-β-D-glucuronide, demethyleneberberine-2-O-sulfate, and demethyleneberberine-2-O-β-D-glucuronide) in rats after oral administration of Rhizoma coptidis extract. Meanwhile, comparative pharmacokinetics and excretions of these analytes in diabetic model rats were also investigated, since Rhizoma coptidis is widely used for the treatment of diabetes. Our results showed that the in vivo existing forms of alkaloid components were phase II metabolites, highlighting the glucuronidation metabolic pathway. In diabetic model rats, the utilization of Rhizoma coptidis alkaloids was significantly increased and the biotransformation of berberine into berberrubine was significantly inhibited.

UHPLC-Q-TOF-MS/MS based screening and identification of the metabolites in vivo after oral administration of betulin

Fitoterapia ◽  
2018 ◽  
Vol 127 ◽  
pp. 29-41 ◽  
Author(s):  
Wendan Zhang ◽  
Honghong Jiang ◽  
Miaomiao Jin ◽  
Qiao Wang ◽  
Qian Sun ◽  
...  
Keyword(s):  
Oral Administration ◽  
Screening And Identification ◽  
Tof Ms
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