Application of PAMAM dendrimers in optical sensing

The Analyst ◽  
2015 ◽  
Vol 140 (4) ◽  
pp. 976-989 ◽  
Author(s):  
E. Soršak ◽  
J. Volmajer Valh ◽  
Š. Korent Urek ◽  
A. Lobnik
Keyword(s):  
Optical Sensors ◽  
Optical Sensing ◽  
Pamam Dendrimer ◽  
Pamam Dendrimers ◽  
Recent Advances

In this review, recent advances have been reported in those PAMAM dendrimer-based optical sensors that are used for the detection of pH, cations, and other analyte.

Targeting Breast Cancer Cells with G4 PAMAM Dendrimers and Valproic Acid Derivative Complexes

2020 ◽  
Vol 20 (15) ◽  
pp. 1857-1872
Author(s):  
Alberto M. Muñoz ◽  
Manuel J. Fragoso-Vázquez ◽  
Berenice P. Martel ◽  
Alma Chávez-Blanco ◽  
Alfonso Dueñas-González ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Cell Lines ◽  
Water Solubility ◽  
Md Simulations ◽  
Pamam Dendrimer ◽  
Pamam Dendrimers ◽  
Force Microscopy ◽  
Micromolar Concentration ◽  
Atomic Force

Background: Our research group has developed some Valproic Acid (VPA) derivatives employed as anti-proliferative compounds targeting the HDAC8 enzyme. However, some of these compounds are poorly soluble in water. Objective: Employed the four generations of Polyamidoamine (G4 PAMAM) dendrimers as drug carriers of these compounds to increase their water solubility for further in vitro evaluation. Methods: VPA derivatives were subjected to Docking and Molecular Dynamics (MD) simulations to evaluate their affinity on G4 PAMAM. Then, HPLC-UV/VIS, 1H NMR, MALDI-TOF and atomic force microscopy were employed to establish the formation of the drug-G4 PAMAM complexes. Results: The docking results showed that the amide groups of VPA derivatives make polar interactions with G4 PAMAM, whereas MD simulations corroborated the stability of the complexes. HPLC UV/VIS experiments showed an increase in the drug water solubility which was found to be directly proportional to the amount of G4 PAMAM. 1H NMR showed a disappearance of the proton amine group signals, correlating with docking results. MALDI-TOF and atomic force microscopy suggested the drug-G4 PAMAM dendrimer complexes formation. Discussion: In vitro studies showed that G4 PAMAM has toxicity in the micromolar concentration in MDAMB- 231, MCF7, and 3T3-L1 cell lines. VPA CF-G4 PAMAM dendrimer complex showed anti-proliferative properties in the micromolar concentration in MCF-7 and 3T3-L1, and in the milimolar concentration in MDAMB- 231, whereas VPA MF-G4 PAMAM dendrimer complex didn’t show effects on the three cell lines employed. Conclusion: These results demonstrate that G4 PAMAM dendrimers are capableof transporting poorly watersoluble aryl-VPA derivate compounds to increase its cytotoxic activity against neoplastic cell lines.

Recent Advances in Supramolecular Analytical Chemistry Using Optical Sensing

2015 ◽  
Vol 115 (15) ◽  
pp. 7840-7892 ◽  
Author(s):  
Lei You ◽  
Daijun Zha ◽  
Eric V. Anslyn
Keyword(s):  
Analytical Chemistry ◽  
Optical Sensing ◽  
Recent Advances

Recent advances in cataluminescence-based optical sensing systems

The Analyst ◽  
2017 ◽  
Vol 142 (9) ◽  
pp. 1415-1428 ◽  
Author(s):  
Si Wang ◽  
Zhiqin Yuan ◽  
Lijuan Zhang ◽  
Yanjun Lin ◽  
Chao Lu
Keyword(s):  
Optical Sensing ◽  
Sensing Systems ◽  
Recent Advances

Recent advances in the development of cataluminescence focused on oxygen, temperature, catalyst and instrumentation are summarized.

scholarly journals Proximal Methods for Plant Stress Detection Using Optical Sensors and Machine Learning

Biosensors ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 193
Author(s):  
Alanna V. Zubler ◽  
Jeong-Yeol Yoon
Keyword(s):  
Machine Learning ◽  
Optical Sensors ◽  
Near Infrared ◽  
Plant Stress ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Detection Methods ◽  
Stress Detection ◽  
Recent Advances ◽  
Wide Range

Plant stresses have been monitored using the imaging or spectrometry of plant leaves in the visible (red-green-blue or RGB), near-infrared (NIR), infrared (IR), and ultraviolet (UV) wavebands, often augmented by fluorescence imaging or fluorescence spectrometry. Imaging at multiple specific wavelengths (multi-spectral imaging) or across a wide range of wavelengths (hyperspectral imaging) can provide exceptional information on plant stress and subsequent diseases. Digital cameras, thermal cameras, and optical filters have become available at a low cost in recent years, while hyperspectral cameras have become increasingly more compact and portable. Furthermore, smartphone cameras have dramatically improved in quality, making them a viable option for rapid, on-site stress detection. Due to these developments in imaging technology, plant stresses can be monitored more easily using handheld and field-deployable methods. Recent advances in machine learning algorithms have allowed for images and spectra to be analyzed and classified in a fully automated and reproducible manner, without the need for complicated image or spectrum analysis methods. This review will highlight recent advances in portable (including smartphone-based) detection methods for biotic and abiotic stresses, discuss data processing and machine learning techniques that can produce results for stress identification and classification, and suggest future directions towards the successful translation of these methods into practical use.

scholarly journals Gold nanoparticles as sensitive optical probes

The Analyst ◽  
2016 ◽  
Vol 141 (5) ◽  
pp. 1611-1626 ◽  
Author(s):  
Zhiqin Yuan ◽  
Cho-Chun Hu ◽  
Huan-Tsung Chang ◽  
Chao Lu
Keyword(s):  
Gold Nanoparticles ◽  
Optical Sensing ◽  
Optical Probes ◽  
Sensing Systems ◽  
Recent Advances

Recent advances in Au NP based optical sensing systems for various analytes based on absorption, fluorescence and SERS are summarized.

scholarly journals Hybrid plasmonic–photonic whispering gallery mode resonators for sensing: a critical review

The Analyst ◽  
2017 ◽  
Vol 142 (6) ◽  
pp. 883-898 ◽  
Author(s):  
Angelo Bozzola ◽  
Sara Perotto ◽  
Francesco De Angelis
Keyword(s):  
Critical Review ◽  
Optical Sensing ◽  
State Of The Art ◽  
Whispering Gallery Mode ◽  
The State ◽  
Whispering Gallery ◽  
Recent Advances ◽  
Wgm Resonators

In this review we present the state of the art and the most recent advances in the field of optical sensing with hybrid plasmonic–photonic whispering gallery mode (WGM) resonators.

scholarly journals Recent Progress on Electromagnetic Field Measurement Based on Optical Sensors

Sensors ◽  
2019 ◽  
Vol 19 (13) ◽  
pp. 2860 ◽  
Author(s):  
Jun Peng ◽  
Shuhai Jia ◽  
Jiaming Bian ◽  
Shuo Zhang ◽  
Jianben Liu ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Electromagnetic Field ◽  
Electric Field ◽  
Magnetic Fluid ◽  
Optical Sensors ◽  
Field Measurement ◽  
Faraday Effect ◽  
Optical Sensing ◽  
Piezoelectric Materials ◽  
Electrostatic Attraction

Electromagnetic field sensors are widely used in various areas. In recent years, great progress has been made in the optical sensing technique for electromagnetic field measurement, and varieties of corresponding sensors have been proposed. Types of magnetic field optical sensors were presented, including probes-based Faraday effect, magnetostrictive materials, and magnetic fluid. The sensing system-based Faraday effect is complex, and the sensors are mostly used in intensive magnetic field measurement. Magnetic field optical sensors based on magnetic fluid have high sensitivity compared to that based on magnetostrictive materials. Three types of electric field optical sensors are presented, including the sensor probes based on electric-optic crystal, piezoelectric materials, and electrostatic attraction. The majority of sensors are developed using the sensing scheme of combining the LiNbO3 crystal and optical fiber interferometer due to the good electro-optic properties of the crystal. The piezoelectric materials-based electric field sensors have simple structure and easy fabrication, but it is not suitable for weak electric field measurement. The sensing principle based on electrostatic attraction is less commonly-used sensing methods. This review aims at presenting the advances in optical sensing technology for electromagnetic field measurement, analyzing the principles of different types of sensors and discussing each advantage and disadvantage, as well as the future outlook on the performance improvement of sensors.

Recent advances in nanomaterial-based electrochemical and optical sensing platforms for microRNA assays

The Analyst ◽  
2019 ◽  
Vol 144 (9) ◽  
pp. 2849-2866 ◽  
Author(s):  
Yi-Han Wang ◽  
Liu-Liu He ◽  
Ke-Jing Huang ◽  
Ying-Xu Chen ◽  
Shu-Yu Wang ◽  
...  
Keyword(s):  
Optical Sensing ◽  
Recent Advances ◽  
Sensing Platforms

This review describes recent efforts in the application of nanomaterials as sensing elements in electrochemical and optical miRNAs assays.

PAMAM dendrimer-based macromolecules and their potential applications: recent advances in theoretical studies

2020 ◽  
Vol 77 (12) ◽  
pp. 6671-6691 ◽  
Author(s):  
S. Mahmood Fatemi ◽  
Seyed Jamilaldin Fatemi ◽  
Zeynab Abbasi
Keyword(s):  
Pamam Dendrimer ◽  
Theoretical Studies ◽  
Recent Advances ◽  
Potential Applications

scholarly journals An Available Strategy for Nasal Brain Transport of Nanocomposite Based on PAMAM Dendrimers via In Situ Gel

Nanomaterials ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 147 ◽  
Author(s):  
Huichao Xie ◽  
Lingjun Li ◽  
Yue Sun ◽  
Yuzhen Wang ◽  
Shuang Gao ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Drug Carriers ◽  
Pamam Dendrimer ◽  
Pamam Dendrimers ◽  
In Situ Gel ◽  
Transport Efficiency ◽  
Plastic Fluid ◽  
The Brain

Polyamidoamine (PAMAM) dendrimers are efficient drug carriers. The presence of a physiological pathway for nasal brain transport provides a potential path for direct brain-targeted delivery of dendrimer nanocomposites. In this study, we synthesized PAMAM dendrimer composites with a nanoscale size; the particle size of PAE (Paeonol)/mPEG (the heterofunctional PEG polymer with a methoxy)-PAMAM G5.NHAc and mPEG-PAMAM G5.NH2-FITC were 72.41 ± 11.58 nm and 96.51 ± 7.77 nm, and the zeta potential of PAE/mPEG-PAMAM G5.NHAc and mPEG-PAMAM G5.NH2-FITC were + 0.57 ± 0.11 mv and + 9.60 ± 0.41 mv, respectively. The EE% and DL% of PAE in PAE/mPEG-PAMAM G5.NHAc were 53.77% and 13.92%, respectively. PAE/mPEG-PAMAM G5.NHAc/DGG ionic-sensitive in situ gel was prepared, the viscosity of solution and gel state were 112 ± 3.2 mPa and 1403 ± 38.5 mPa, respectively. The in vitro goat mucoadhesive strength of the gel was 4763.36 ± 85.39 dyne/cm2. In situ gel system was proven to be a non-Newtonian pseudo-plastic fluid with shear thinning, thixotropy and yield stress. The optimal model of PAE released from PAE/mPEG-PAMAM G5.NHAc and PAE/mPEG-PAMAM G5.NHAc/DGG were the Higuchi equation and the Korsmeyer-Peppas equation, respectively. The cytotoxicity of the nanocomposites showed a concentration-dependence, and the cell viabilities of PAE/mPEG-PAMAM G5.NHAc were both higher than 95% between 0.0001 μM and 10 μM. mPEG-PAMAM G5.NH2-FITC was efficiently taken up by cells and exhibited strong fluorescence in the cytoplasm and nucleus. Significant accumulation of nanocomposites was observed in the brain after administration of the in situ gel group, and maximum accumulation was reached at 12 h. A small amount of accumulation was observed in the nanocomposite solution group only at 2 h. Therefore, the direct nasal brain transport efficiency of PAMAM dendrimer nanocomposites can be significantly improved after combining with in situ gel. PAMAM dendrimer nanocomposite/DGG is a potential drug delivery system for nasal brain transport.

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