Preparation, characterization, and in vitro evaluation of folate-modified mesoporous bioactive glass for targeted anticancer drug carriers

2013 ◽  
Vol 1 (44) ◽  
pp. 6147 ◽  
Author(s):  
Hsiu-Mei Lin ◽  
Hung-Yi Lin ◽  
Ming-Hsien Chan
Keyword(s):  
Bioactive Glass ◽  
Anticancer Drug ◽  
Drug Carriers ◽  
In Vitro Evaluation ◽  
Mesoporous Bioactive Glass

scholarly journals Integration of Mesoporous Bioactive Glass Nanoparticles and Curcumin into PHBV Microspheres as Biocompatible Composite for Drug Delivery Applications

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3177
Author(s):  
Arturo E. Aguilar-Rabiela ◽  
Aldo Leal-Egaña ◽  
Qaisar Nawaz ◽  
Aldo R. Boccaccini
Keyword(s):  
Drug Delivery ◽  
Bioactive Glass ◽  
Biomedical Applications ◽  
Drug Carriers ◽  
Bioactive Glasses ◽  
Composite Microspheres ◽  
Convenient Approach ◽  
Model Drug ◽  
Mesoporous Bioactive Glass

Bioactive glasses (BGs) are being increasingly considered for biomedical applications. One convenient approach to utilize BGs in tissue engineering and drug delivery involves their combination with organic biomaterials in order to form composites with enhanced biocompatibility and biodegradability. In this work, mesoporous bioactive glass nanoparticles (MBGN) have been merged with polyhydroxyalkanoate microspheres with the purpose to develop drug carriers. The composite carriers (microspheres) were loaded with curcumin as a model drug. The toxicity and delivery rate of composite microspheres were tested in vitro, reaching a curcumin loading efficiency of over 90% and an improving of biocompatibility of different concentrations of MBGN due to its administrations through the composite. The composite microspheres were tested in terms of controlled release, biocompatibility and bioactivity. Our results demonstrate that the composite microspheres can be potentially used in biomedicine due to their dual effects: bioactivity (due to the presence of MBGN) and curcumin release capability.

scholarly journals Synthesis and Characterization of Silver–Strontium (Ag-Sr)-Doped Mesoporous Bioactive Glass Nanoparticles

Gels ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 34
Author(s):  
Shaher Bano ◽  
Memoona Akhtar ◽  
Muhammad Yasir ◽  
Muhammad Salman Maqbool ◽  
Akbar Niaz ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Composite Coatings ◽  
Antibacterial Properties ◽  
Bone Diseases ◽  
Osteogenic Potential ◽  
Diffusion Method ◽  
Charge Composition ◽  
In Vitro Bioactivity ◽  
Mesoporous Bioactive Glass

Biomedical implants are the need of this era due to the increase in number of accidents and follow-up surgeries. Different types of bone diseases such as osteoarthritis, osteomalacia, bone cancer, etc., are increasing globally. Mesoporous bioactive glass nanoparticles (MBGNs) are used in biomedical devices due to their osteointegration and bioactive properties. In this study, silver (Ag)- and strontium (Sr)-doped mesoporous bioactive glass nanoparticles (Ag-Sr MBGNs) were prepared by a modified Stöber process. In this method, Ag+ and Sr2+ were co-substituted in pure MBGNs to harvest the antibacterial properties of Ag ions, as well as pro-osteogenic potential of Sr2 ions. The effect of the two-ion concentration on morphology, surface charge, composition, antibacterial ability, and in-vitro bioactivity was studied. Scanning electron microscopy (SEM), X-Ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) confirmed the doping of Sr and Ag in MBGNs. SEM and EDX analysis confirmed the spherical morphology and typical composition of MBGNs, respectively. The Ag-Sr MBGNs showed a strong antibacterial effect against Staphylococcus carnosus and Escherichia coli bacteria determined via turbidity and disc diffusion method. Moreover, the synthesized Ag-Sr MBGNs develop apatite-like crystals upon immersion in simulated body fluid (SBF), which suggested that the addition of Sr improved in vitro bioactivity. The Ag-Sr MBGNs synthesized in this study can be used for the preparation of scaffolds or as a filler material in the composite coatings for bone tissue engineering.

Europium-Containing Mesoporous Bioactive Glass Scaffolds for Stimulating in Vitro and in Vivo Osteogenesis

2016 ◽  
Vol 8 (18) ◽  
pp. 11342-11354 ◽  
Author(s):  
Chengtie Wu ◽  
Lunguo Xia ◽  
Pingping Han ◽  
Lixia Mao ◽  
Jiacheng Wang ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Mesoporous Bioactive Glass

In vitro evaluation of novel titania‐containing borate bioactive glass scaffolds

2020 ◽  
Vol 109 (2) ◽  
pp. 146-158
Author(s):  
Romina Shafaghi ◽  
Omar Rodriguez ◽  
Anthony W. Wren ◽  
Loraine Chiu ◽  
Emil H. Schemitsch ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
In Vitro Evaluation ◽  
Borate Bioactive Glass

Mesoporous Bioactive Glass Promoted Osteoblast Proliferation and Differentiation In Vitro

2019 ◽  
Vol 9 (4) ◽  
pp. 462-467
Author(s):  
Jianwei Chen ◽  
Xiaosheng Yu ◽  
Hao Ji ◽  
Zhen Zong ◽  
Wei Hong ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Osteoblast Proliferation ◽  
Proliferation And Differentiation ◽  
Mesoporous Bioactive Glass

The Primary Investigation on Biological Effect of Mesoporous Bioactive Glass In Vivo

2013 ◽  
Vol 750-752 ◽  
pp. 1651-1655
Author(s):  
Bai Yan Sui ◽  
Cheng Tie Wu ◽  
Jiao Sun
Keyword(s):  
Bioactive Glass ◽  
Biological Effect ◽  
Degradation Products ◽  
Long Term Effect ◽  
Liver And Kidney ◽  
Mesoporous Bioactive Glass

Mesoporous bioactive glass (MBG) has superior bioactivity and degradation than non-mesoporous bioactive glass (BG) in vitro. But the biological effect of MBG in vivo is still unknown. In this study, MBG powders with 20μm were implanted into the femoral condyles in SD rats. BG powders with 20μm were used as a control. The local degradation and osteogenesis were observed at 1 week and 4 weeks after implantation, and the systemic toxicity of the degradation products were also evaluated simultaneously. The results revealed MBG powders had the faster rate of degradation and better osteogenesis effect than BG powders at 4 weeks, although the most of material still remained in situ. Histopathological analyses indicated the degradation products did not have any damage to major organs such as liver and kidney. In conclusion, this preliminary study demonstrated that MBG powders have more excellent biological effect at 4 weeks than that of BG in vivo. However the long-term effect needs to be confirmed.

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