Biomimetic SERS substrate: peptide recognition elements for highly selective chemical detection in chemically complex media

2013 ◽  
Vol 1 (22) ◽  
pp. 6543 ◽  
Author(s):  
Saide Z. Nergiz ◽  
Naveen Gandra ◽  
Mikella E. Farrell ◽  
Limei Tian ◽  
Paul M. Pellegrino ◽  
...  
Keyword(s):  
Chemical Detection ◽  
Sers Substrate ◽  
Complex Media ◽  
Peptide Recognition ◽  
Substrate Peptide ◽  
Recognition Elements ◽  
Selective Chemical

scholarly journals Molecular Modeling of Signal Peptide Recognition by Eukaryotic Sec Complexes

2021 ◽  
Vol 22 (19) ◽  
pp. 10705
Author(s):  
Pratiti Bhadra ◽  
Volkhard Helms
Keyword(s):  
Protein Translocation ◽  
Conformational Dynamics ◽  
Primary Component ◽  
Signal Peptides ◽  
Accessory Proteins ◽  
Simulation Studies ◽  
Peptide Recognition ◽  
Substrate Peptide ◽  
Modelling Studies ◽  
Lateral Gate

Here, we review recent molecular modelling and simulation studies of the Sec translocon, the primary component/channel of protein translocation into the endoplasmic reticulum (ER) and bacterial periplasm, respectively. Our focus is placed on the eukaryotic Sec61, but we also mention modelling studies on prokaryotic SecY since both systems operate in related ways. Cryo-EM structures are now available for different conformational states of the Sec61 complex, ranging from the idle or closed state over an inhibited state with the inhibitor mycolactone bound near the lateral gate, up to a translocating state with bound substrate peptide in the translocation pore. For all these states, computational studies have addressed the conformational dynamics of the translocon with respect to the pore ring, the plug region, and the lateral gate. Also, molecular simulations are addressing mechanistic issues of insertion into the ER membrane vs. translocation into the ER, how signal-peptides are recognised at all in the translocation pore, and how accessory proteins affect the Sec61 conformation in the co- and post-translational pathways.

Biomimetic Chemosensor: Designing Peptide Recognition Elements for Surface Functionalization of Carbon Nanotube Field Effect Transistors

ACS Nano ◽  
2009 ◽  
Vol 4 (1) ◽  
pp. 452-458 ◽  
Author(s):  
Zhifeng Kuang ◽  
Sang N. Kim ◽  
Wendy J. Crookes-Goodson ◽  
Barry L. Farmer ◽  
Rajesh R. Naik
Keyword(s):  
Carbon Nanotube ◽  
Surface Functionalization ◽  
Field Effect ◽  
Field Effect Transistors ◽  
Peptide Recognition ◽  
Recognition Elements

scholarly journals Hydrogels: Hydrogel Interferometry for Ultrasensitive and Highly Selective Chemical Detection (Adv. Mater. 46/2018)

2018 ◽  
Vol 30 (46) ◽  
pp. 1870352 ◽  
Author(s):  
Mo Sun ◽  
Ruobing Bai ◽  
Xingyun Yang ◽  
Jiaqi Song ◽  
Meng Qin ◽  
...  
Keyword(s):  
Chemical Detection ◽  
Selective Chemical

Investigation of microcantilever array with ordered nanoporous coatings for selective chemical detection

2010 ◽  
Author(s):  
J.-H. Lee ◽  
R. T. J. Houk ◽  
A. Robinson ◽  
J. A. Greathouse ◽  
S. M. Thornberg ◽  
...  
Keyword(s):  
Chemical Detection ◽  
Selective Chemical ◽  
Microcantilever Array

scholarly journals Hydrogel Interferometry for Ultrasensitive and Highly Selective Chemical Detection

2018 ◽  
Vol 30 (46) ◽  
pp. 1804916 ◽  
Author(s):  
Mo Sun ◽  
Ruobing Bai ◽  
Xingyun Yang ◽  
Jiaqi Song ◽  
Meng Qin ◽  
...  
Keyword(s):  
Chemical Detection ◽  
Selective Chemical

METAL-OXIDE INTERFACES OBTAINED BY SELECTIVE CHEMICAL REDUCTION OF LAMELLAR OXIDE-OXIDE EUTECTIC STRUCTURES

1990 ◽  
Vol 51 (C1) ◽  
pp. C1-781-C1-787
Author(s):  
B. BONVALOT ◽  
G. DHALENNE ◽  
F. MILLOT ◽  
A. REVCOLEVSCHI
Keyword(s):  
Metal Oxide ◽  
Chemical Reduction ◽  
Oxide Interfaces ◽  
Selective Chemical

Solving The Conflicting Dips Problem In Complex Media By Considering All Possible Dips In Crs Method

2014 ◽  
Author(s):  
Aamin Shahbazi ◽  
Deva Ghosh ◽  
Mehrdad Soleimani ◽  
Juergen Mann
Keyword(s):  
Complex Media
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