“On water” catalyst-free, column chromatography-free and atom economical protocol for highly diastereoselective synthesis of novel class of 3-substituted, 3-hydroxy-2-oxindole scaffolds at room temperature

RSC Advances ◽  
2014 ◽  
Vol 4 (11) ◽  
pp. 5343 ◽  
Author(s):  
Pramod B. Thakur ◽  
Harshadas M. Meshram
Keyword(s):  
Column Chromatography ◽  
Room Temperature ◽  
Diastereoselective Synthesis ◽  
Catalyst Free

Naturally Occurring Organic Acid-catalyzed Facile Diastereoselective Synthesis of Biologically Active (E)-3-(arylimino)indolin-2-one Derivatives in Water at Room Temperature

2019 ◽  
Vol 23 (16) ◽  
pp. 1778-1788 ◽  
Author(s):  
Gurpreet Kaur ◽  
Arvind Singh ◽  
Kiran Bala ◽  
Mamta Devi ◽  
Anjana Kumari ◽  
...  
Keyword(s):  
Room Temperature ◽  
Biologically Active ◽  
Environmentally Benign ◽  
Diastereoselective Synthesis ◽  
Substituted Anilines ◽  
Reaction Conditions ◽  
Naturally Occurring ◽  
Acid Catalyzed ◽  
Reaction Media ◽  
Column Chromatographic

A simple, straightforward and efficient method has been developed for the synthesis of (E)-3-(arylimino)indolin-2-one derivatives and (E)-2-((4-methoxyphenyl)imino)- acenaphthylen-1(2H)-one. The synthesis of these biologically-significant scaffolds was achieved from the reactions of various substituted anilines and isatins or acenaphthaquinone, respectively, using commercially available, environmentally benign and naturally occurring organic acids such as mandelic acid or itaconic acid as catalyst in aqueous medium at room temperature. Mild reaction conditions, energy efficiency, good to excellent yields, environmentally benign conditions, easy isolation of products, no need of column chromatographic separation and the reusability of reaction media are some of the significant features of the present protocol.

Visible-light-initiated Catalyst-free Oxidative Cleavage of Triaryl-Substituted Alkenes C=C Bonds under Ambient Conditions

2021 ◽  
Author(s):  
Wenjing Li ◽  
Shun Li ◽  
Lihua Luo ◽  
Yichen Ge ◽  
Jiaqi Xu ◽  
...  
Keyword(s):  
Visible Light ◽  
Room Temperature ◽  
Ambient Air ◽  
Oxidative Cleavage ◽  
Ambient Conditions ◽  
Blue Led ◽  
Catalyst Free

The catalyst-free oxidative cleavage of (Z)-triaryl-substituted alkenes bearing pyridyl motif with ambient air under irradiation of blue LED at room temperature has been developed. The reaction was facile and scalable,...

An efficient construction of CN bond under catalyst‐free and room temperature conditions

2021 ◽  
Vol 58 (5) ◽  
pp. 1179-1191
Author(s):  
Jinpeng Zhang ◽  
Jing Liu ◽  
Lei Dai ◽  
Yuqian Ge ◽  
Linlin Xu ◽  
...  
Keyword(s):  
Room Temperature ◽  
Catalyst Free ◽  
Temperature Conditions ◽  
Efficient Construction

ChemInform Abstract: Diastereoselective Synthesis of N-Alkylated Octahydroacridines via a Catalyst-Free SNAr Approach.

ChemInform ◽  
2016 ◽  
Vol 47 (7) ◽  
pp. no-no
Author(s):  
Nagendra Prasad Muddala ◽  
Baskar Nammalwar ◽  
Subhashini Selvaraju ◽  
Richard A. Bunce
Keyword(s):  
Diastereoselective Synthesis ◽  
Catalyst Free

ChemInform Abstract: A Catalyst-Free N-Benzyloxycarbonylation of Amines in Aqueous Micellar Media at Room Temperature.

ChemInform ◽  
2008 ◽  
Vol 39 (47) ◽  
Author(s):  
Janhavi J. Shrikhande ◽  
Manoj B. Gawande ◽  
Radha V. Jayaram
Keyword(s):  
Room Temperature ◽  
Micellar Media ◽  
Catalyst Free

Catalyst-Free Oxidative [3+2] Cycloaddition of Phenols and Styrenes in the Presence of a 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone/1,1,1,3,3,3-hexafluoropropan-2-ol System

Synlett ◽  
2017 ◽  
Vol 28 (19) ◽  
pp. 2619-2623 ◽  
Author(s):  
Yunxia Wang ◽  
Na Cui ◽  
Yu Zhao
Keyword(s):  
Room Temperature ◽  
Catalyst Free

A catalyst-free oxidative [3+2] cycloaddition of phenols and styrenes was developed with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone as the oxidant and 1,1,1,3,3,3-hexafluoropropan-2-ol as the solvent at room temperature. With this method, a broad range of dihydrobenzofurans were efficiently and quickly obtained from readily available phenols and styrenes.

Sodium sulphide promoted synthesis of fused quinoline at room temperature

2021 ◽  
Author(s):  
Rashmi Singh ◽  
Vishal Prasad Sharma ◽  
Priyanka Yadav ◽  
Priyanka Sonker ◽  
Radhey Mohan Singh ◽  
...  
Keyword(s):  
Room Temperature ◽  
Sodium Sulphide ◽  
Catalyst Free

A novel, simple and eco-friendly strategy for the synthesis of thiopyrano[4,3-b]quinolin-1-ones and pyrrolo[3,4-b]quinolin-1-ones from 2-alkynylquinoline-3-carbonitriles and sodium sulphide (Na2S·9H2O) under catalyst-free conditions at RT.

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