A targeted strategy for ingredients analysis and enrichment by mass-based preparative LC method: application to three isomeric C21 steroids from Marsdenia tenacissima

RSC Advances ◽  
2014 ◽  
Vol 4 (15) ◽  
pp. 7660 ◽  
Author(s):  
Feng Zhang ◽  
Lianna Sun ◽  
Le Yang ◽  
Qinghua Zeng ◽  
Xia Tao ◽  
...  
Keyword(s):  
Preparative Lc ◽  
Marsdenia Tenacissima

Simultaneous Separation of Four Flavonoids and Two Astragalosides from Radix Astragali by Semi-Preparative LC

2010 ◽  
Vol 71 (3-4) ◽  
pp. 225-231 ◽  
Author(s):  
Xinrong Dong ◽  
Yizeng Liang ◽  
Bing Wang ◽  
Xiaohong Long
Keyword(s):  
Radix Astragali ◽  
Simultaneous Separation ◽  
Preparative Lc

PHYTOCHEMICAL, PHARMACOLOGICAL SCREENING AND IMPORTANCE OF MARSDENIA TENACISSIMA: A REVIEW

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (4) ◽  
pp. 7-22
Author(s):  
Mayur Porwal ◽  
◽  
Arvind Kumar ◽  
Kamal K. Maheshwari ◽  
Najam A. Khan ◽  
...  
Keyword(s):  
Heart Disease ◽  
Skin Disease ◽  
Recent Literature ◽  
Biological Activities ◽  
Intermittent Fever ◽  
Pharmacological Activities ◽  
Phytochemical Constituents ◽  
Pharmacological Screening ◽  
Anti Hiv ◽  
Marsdenia Tenacissima

In conventional methods of medication, Marsdenia tenacissima (family: Apocynaceae) is used in the treatment of scurvy, urinary diseases, arthritis, heart disease, skin disease, pruritus, vomiting and intermittent fever. Estimation of biological activities confirmed that M. tenacissima plant shows antipyretic, antioxidant, anticancer and anti-HIV activities. This assessment presents the phytochemical constituents, traditional importance and pharmacological activities accounted for the plant in recent literature and it will be supportive to explore incisive information about M. tenacissima for the researchers.

Determination of Melengestrol Acetate in Feedstuffs with Liquid Chromatographic Preparatory Column Cleanup and Quantitative Analysis

1988 ◽  
Vol 71 (4) ◽  
pp. 707-709
Author(s):  
Jim L Weigand ◽  
Daniel S Dille
Keyword(s):  
Liquid Chromatography ◽  
Quantitative Analysis ◽  
Sodium Sulfate ◽  
Alumina Column ◽  
Melengestrol Acetate ◽  
Preparative Lc ◽  
Time Savings ◽  
Commercial Feeds ◽  
Liquid Chromatographic

Abstract Melengestrol acetate (MGA) is determined by liquid chromatography using a fraction from preparatory LC as a means of sample cleanup for feedstuffs, both dry and liquid. Dry ground feed is Soxhlet extracted with hexane and passed through a 2% deactivated alumina column for initial cleanup. The eluate is evaporated, redissolved in methanol, filtered, and injected onto a preparatory LC column. The fraction containing MGA is separated from the remaining matrix, evaporated to dryness, dissolved in methanol, and quantitated by LC analysis. Liquid supplements are extracted in methanol, and the extract is evaporated to near dryness. The residue is diluted with water, extracted with chloroform, passed through sodium sulfate, and evaporated to dryness. The remaining sample is dissolved in methanol prior to preparative LC and quantitative LC. Recoveries for 2 laboratory- fortified commercial feeds, one dry and one liquid, containing 0.39 and 0.40 mg/lb, were 98.3% ± 4.4 and 95.8% ± 4.3, respectively. Results compare favorably with existing methods. Up to a 4-fold time savings was realized by this method without automation.

Marsdenia tenacissima extract enhances gefitinib efficacy in non-small cell lung cancer xenografts

Phytomedicine ◽  
2015 ◽  
Vol 22 (5) ◽  
pp. 560-567 ◽  
Author(s):  
Shu-Yan Han ◽  
Wei Zhao ◽  
Hong Sun ◽  
Ning Zhou ◽  
Fei Zhou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Marsdenia Tenacissima

Marsdenia tenacissima: A Review of Traditional Uses, Phytochemistry and Pharmacology

2018 ◽  
Vol 46 (07) ◽  
pp. 1449-1480 ◽  
Author(s):  
Peile Wang ◽  
Jing Yang ◽  
Zhenfeng Zhu ◽  
Xiaojian Zhang
Keyword(s):  
Quality Control ◽  
Multidrug Resistance ◽  
Control Method ◽  
Food Poisoning ◽  
Bioactive Constituents ◽  
Resistance Reversal ◽  
Wide Clinical Application ◽  
Marsdenia Tenacissima

The stems and roots of Marsdenia tenacissima (Roxb.) Wight et Arn., a traditional Chinese medicine and Dai herbal medicine, have been widely used for the treatment of asthma, trachitis, tonsillitis, pharyngitis, cystitis, pneumonia and drug or food poisoning. Nowadays, the extract of Marsdenia tenacissima, under the trademark of “Xiao-ai-ping”, is widely used in clinic for the treatment of different cancers in China. To date, approximately 196 chemical ingredients covering steroids, triterpenes and organic acids have been identified from different parts of this plant. Steroids are the major characteristic and bioactive constituents of this plant. Modern pharmacology has demonstrated that the crude extracts and steroids have various in vitro and in vivo pharmacological activities, such as multidrug resistance reversal, antitumor, anti-angiogenic, immunomodulation and anti-HIV activities. The multidrug resistance reversal of steroids provided evidence for the use of this herb in clinic. However, despite wide clinical application, clinical trials, quality control method, pharmacokinetic and toxicity research on Marsdenia tenacissima were seldom reported and deserved further efforts. The present review aimed to achieve a comprehensive and up-to-date investigation in ethnopharmacology, phytochemistry, pharmacology, clinical study, pharmacokinetics, toxicology and quality control of Marsdenia tenacissima. In addition, the possible perspectives and trends for future studies of Marsdenia tenacissima have also been put forward. It is believed that this review would provide a theoretical basis and valuable data for future in-depth studies and applications.

scholarly journals The Antitumor Activities of Marsdenia tenacissima

2018 ◽  
Vol 8 ◽  
Author(s):  
Xiang Wang ◽  
Yuanliang Yan ◽  
Xi Chen ◽  
Shuangshuang Zeng ◽  
Long Qian ◽  
...  
Keyword(s):  
Antitumor Activities ◽  
Marsdenia Tenacissima
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